公开(公告)号：US20220240542A1

公开(公告)日：2022-08-04

申请号：US17587582

申请日：2022-01-28

Applicant: ZIVO Bioscience, Inc.

Inventor： William P. Pfund ,  Amy E. Steffek ,  Andrew A. Dahl

IPC: A23K10/10 ,  A23K50/75 ,  A23K20/163

Abstract: A method and compound for promoting growth and priming the immune system in both animals and humans are disclosed. The disclosed method utilizes a compound derived from one or more of a lipopolysaccharide, Lipid A, and fractions, derivatives, and cellular components thereof of gram-negative bacteria. The compound is combined with conventional feed, such as corn-soy feed, for administration to animals, such as poultry. Human application is possible, as well. Kinomic analysis of tissues collected from sacrificed birds fed the dietary mixture of the inventive compound and conventional feed suggests that the biomass causes an alteration of signaling in multiple growth-related pathways. These pathways include, but are not limited to, those associated with the vascular endothelial growth factor (VEGF), the mitogen-activated protein kinase (MAPK or MAP kinase), Ak strain transforming (Akt), and the neurotrophic tropomyosin-related kinase (NTRK). Evidence supports the conclusion that this alteration represents the modulation of the various pathways.

公开(公告)号：US10232028B2

公开(公告)日：2019-03-19

申请号：US14898091

申请日：2014-06-13

Applicant: Zivo Bioscience, Inc.

Inventor： Andrew Dahl

IPC: A61K39/00 ,  A61K39/02 ,  A61K39/295 ,  A61K39/09 ,  A61K36/02 ,  A61K36/06 ,  A61K35/74 ,  A61K36/10 ,  A61K35/744 ,  A61K39/108

Abstract: The present invention discloses isolates and fractions from a phyto-percolate and methods for affecting various cytokines by administering an effective amount of one or more of said isolates or fractions to an animal. In various exemplary embodiments, the isolates are useful for the treatment of bovine, canine and swine infection or inflammation, including bovine mastitis, by regulation of TNF-a, lactoferrin, IFN-γ, IL-I β, serum amyloid-A (SAA), IL-6 and/or β-defensin associated with infection or an immune response generally.

公开(公告)号：US20180021392A1

公开(公告)日：2018-01-25

申请号：US15550749

申请日：2016-02-16

Applicant: Zivo Bioscience, Inc.

Inventor： Andrew A. Dahl ,  Amy E. Steffek

IPC: A61K36/05 ,  A61K9/00

CPC classification number: A61K36/05 ,  A23V2200/02 ,  A23V2200/324 ,  A61K9/0053 ,  A61K36/02

Abstract: An algal biomass and supernatant derived from at least one species of algae exhibits anti-inflammatory and immune response modulating properties. Methods of reducing the symptoms of or treating a condition or disease in an animal, including bovine mastitis and Bovine Respiratory Disease Complex, and the pain and discomfort caused by osteoarthritis, injury or overexertion or muscle and connective tissue strains, comprises administering to the animal in need thereof an algal biomass or supernatant derived from at least one species of algae, or an extract, derivative or biologically active compound derived from the algae species, biomass or supernatant, or compositions thereof.

公开(公告)号：US20210353732A1

公开(公告)日：2021-11-18

申请号：US17320706

申请日：2021-05-14

Applicant: ZIVO Bioscience, Inc.

Inventor： Andrew A. Dahl ,  William P. Pfund ,  Amy E. Steffek

IPC: A61K39/02 ,  A61K35/74 ,  A61P33/02

Abstract: An effective treatment mechanism in controlling a variety of diseases by modulating the inflammatory response often associated with disease is disclosed. The disclosed inventive concept is based on the modulation of TLR4 by use of a member of the Variovorax group or the Rhodobacter group. Specifically, the Gram-negative bacterium Variovorax paradoxus or the Gram-negative bacterium Rhodobacter sphaeroides is used according to the disclosed inventive concept in the treatment of disease by reducing or inhibiting inflammatory responses.

公开(公告)号：US11065287B2

公开(公告)日：2021-07-20

申请号：US15550749

申请日：2016-02-16

Applicant: Zivo Bioscience, Inc.

Inventor： Andrew A. Dahl ,  Amy E. Steffek

IPC: A61K36/05 ,  A61K36/02 ,  A61K9/00

Abstract: An algal biomass and supernatant derived from at least one species of algae exhibits anti-inflammatory and immune response modulating properties. Methods of reducing the symptoms of or treating a condition or disease in an animal, including bovine mastitis and Bovine Respiratory Disease Complex, and the pain and discomfort caused by osteoarthritis, injury or overexertion or muscle and connective tissue strains, comprises administering to the animal in need thereof an algal biomass or supernatant derived from at least one species of algae, or an extract, derivative or biologically active compound derived from the algae species, biomass or supernatant, or compositions thereof.

公开(公告)号：US20180255820A1

公开(公告)日：2018-09-13

申请号：US15913712

申请日：2018-03-06

Applicant: Zivo Bioscience, Inc.

Inventor： Andrew A. Dahl

IPC: A23L33/135 ,  A23P10/35 ,  A23P10/40 ,  A23L27/10 ,  A23L7/13 ,  A21D2/36 ,  A21D13/064

CPC classification number: A23L33/135 ,  A21D2/36 ,  A21D13/064 ,  A23L7/13 ,  A23L17/60 ,  A23L27/10 ,  A23L33/195 ,  A23P10/35 ,  A23P10/40 ,  A23V2002/00

Abstract: An algal-derived consumable comprises: (i) an algal biomass derived from at least one species of algae, such as Klebsormidium; and (ii) optionally at least one additional ingredient, such as flavoring ingredients, colorants, seasonings, food additives, food components, and nutrients. The consumable may comprise a dietary supplement, a food ingredient or a finished food product. A method of manufacturing a consumable comprises: harvesting raw wet algae, removing water to produce a de-watered algal material; optionally cutting and/or shaping the de-watered material; drying; and optionally seasoning.

公开(公告)号：US20240350623A1

公开(公告)日：2024-10-24

申请号：US18444286

申请日：2024-02-16

Applicant: Zivo Bioscience, Inc.

Inventor： Amy E. Steffek ,  Andrew A. Dahl ,  William P. Pfund

IPC: A61K39/39 ,  A23K10/16 ,  A23K20/163 ,  A23K50/75 ,  A61K31/739 ,  A61K35/74 ,  A61K39/00 ,  A61K39/02 ,  A61P33/02

CPC classification number: A61K39/39 ,  A23K10/16 ,  A23K20/163 ,  A23K50/75 ,  A61K31/739 ,  A61K35/74 ,  A61K39/0208 ,  A61P33/02 ,  A61K2039/552 ,  A61K2039/55572

Abstract: A method and compound for altering the status of both innate and adaptive immune pathways in both animals and humans are disclosed. The status alteration results in the immune response being primed whereby an accelerated and more robust response is generated when the animal or human is challenged by pathogens that lead to a wide range of disease states. The disclosed method utilizes a compound derived from a lipopolysaccharide (LPS) of gram-negative bacteria. The compound itself is a natural product with no observed adverse environmental impact. By priming the immune pathways according to the disclosed inventive concept, the severity of various disease states can be reduced, can be resolved more quickly, or can be avoided entirely.

公开(公告)号：US20220233608A1

公开(公告)日：2022-07-28

申请号：US17410016

申请日：2021-08-24

Applicant: ZIVO Bioscience, Inc.

Inventor： Amy E. Steffek ,  Andrew A. Dahl ,  William P. Pfund

IPC: A61K35/74 ,  A23K50/75 ,  A23K10/12 ,  A23K10/18 ,  A23K20/163

Abstract: A method and compound for promoting growth in both animals and humans are disclosed. The disclosed method utilizes a compound derived from a lipopolysaccharide (LPS) of gram-negative bacteria. The compound itself is a natural product with no observed adverse environmental impact. The compound is combined with conventional feed, such as a corn-soy feed, for administration to animals, such as poultry. Human application is possible, as well. The combination of the disclosed inventive compound and conventional feed works through multiple growth-related pathways within, for example, in healthy birds to enhance growth performance while also priming the immune system to expedite response to a disease challenge should one arise. Data indicate that the dietary mixture of the inventive compound in conventional feed suggests that the biomass alters the signaling of multiple growth-related pathways.

公开(公告)号：US20220226394A1

公开(公告)日：2022-07-21

申请号：US17576339

申请日：2022-01-14

Applicant: ZIVO Bioscience, Inc.

Inventor： Amy E. Steffek ,  William P. Pfund ,  Andrew A. Dahl

IPC: A61K35/74 ,  A61P33/02 ,  A23K10/16 ,  A23K10/30

Abstract: A treatment compound and its use in the prevention and treatment diseases are disclosed. The compound comprises one or more materials selected from an algal biomass/supernatant (including both algae and bacteria), a bacterial biomass, and isolated and purified compound(s) as well as specific active sites or structures on those compounds. The treatment compound and the use of such a compound such as that derived from a bacterium that appears to selectively alter one or more TLR pathways in the prevention and treatment of disease in both animals and humans. The bacteria are selected from the group consisting of Algoriphagus sp., Bosea sp., Brevundimonas sp., Desulfovibrio sp., Microbacterium sp., Sphingomonas sp., and Variovorax sp. The disclosed inventive compound and method of treatment find particular application in the treatment of disease in poultry, particularly in the prevention and treatment of coccidiosis.

公开(公告)号：US20200330535A1

公开(公告)日：2020-10-22

申请号：US15998619

申请日：2017-02-15

Applicant: Zivo Bioscience, Inc

Inventor： Andrew A. Dahl ,  Amy E. Steffek

IPC: A61K36/05 ,  A23K10/30 ,  A23L33/105 ,  A23K50/10 ,  A23L17/60 ,  A23L33/00 ,  A61K9/00

Abstract: An algal biomass and supernatant derived from at least one species of algae exhibits the ability to maintain general health in humans and non-human animals and promote a healthy immune system in them. Food, feed and nutritional supplements comprising an algal biomass or supernatant derived from at least one species of algae are described. Methods of maintaining general health or promoting a healthy immune system in humans and non-human animals comprises administering to the animal in need thereof an algal biomass or supernatant derived from at least one species of algae, or an extract, derivative or homeopathic compound derived from the algae species, biomass or supernatant, or a composition thereof.