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    Antimicrobial peptides
    2.
    发明授权
    Antimicrobial peptides 有权
    抗菌肽

    公开(公告)号：US09352015B2

    公开(公告)日：2016-05-31

    申请号：US12793666

    申请日：2010-06-03

    申请人： Robert S. Hodges ,  Ziqing Jiang

    发明人： Robert S. Hodges ,  Ziqing Jiang

    IPC分类号： A61K38/16

    CPC分类号： A61K38/16

    摘要： Disclosed are antimicrobial peptides with useful or superior properties such as antimicrobial activity, desirable levels of hemolysis, and advantageous therapeutic index against various microorganisms, especially Pseudomonas aeruginosa, Acinetobacter baumannii and Staphylococcus aureus. Also provided are methods of to control microbial growth and pharmaceutical compositions to treat or prevent microbial infections. Certain peptides are disclosed utilizing a structure-based rational modification of antimicrobial peptide D1, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face, or peptides with one or more amino acids in the D configuration, and peptides with all amino acids in the D configuration. Modified peptide analogs herein can demonstrate one or more properties such as improved antimicrobial activity, specificity, and resistance to degradation. Compositions disclosed herein are useful as antibiotics, including as broad spectrum antibiotics.

    摘要翻译： 公开了具有有用或优异性质的抗微生物肽，例如抗微生物活性，期望的溶血水平，以及针对各种微生物，特别是铜绿假单胞菌，鲍氏不动杆菌和金黄色葡萄球菌的有利治疗指数。 还提供了控制微生物生长和药物组合物以治疗或预防微生物感染的方法。 公开了利用基于结构的抗微生物肽D1的合理修饰，在非极性或极性表面上的肽中心附近或附近具有单个D- / L-氨基酸置换或带电残基取代的某些肽，或具有一个或多个 D构型中更多的氨基酸，以及D构型中所有氨基酸的肽。 本文中修饰的肽类似物可以证明一种或多种性质，例如改善的抗微生物活性，特异性和抗降解性。 本文公开的组合物可用作抗生素，包括作为广谱抗生素。

    Pre-stressed concrete track slab of slab-type ballast-less track
    3.
    发明授权
    Pre-stressed concrete track slab of slab-type ballast-less track 有权
    预应力混凝土轨道板坯式无轨道

    公开(公告)号：US09222225B2

    公开(公告)日：2015-12-29

    申请号：US13994931

    申请日：2011-12-15

    申请人： Jijun Wang ,  Cheng Jiang ,  Weibin Liu ,  Yong Zhao ,  Meng Wang ,  Ziqing Jiang ,  Jia Fan ,  Xianggang Du ,  Lu Chunfang

    发明人： Jijun Wang ,  Cheng Jiang ,  Weibin Liu ,  Yong Zhao ,  Meng Wang ,  Ziqing Jiang ,  Jia Fan ,  Xianggang Du ,  Lu Chunfang

    IPC分类号： E01B1/00 ,  E01B3/40

    CPC分类号： E01B1/002 ,  E01B3/40

    摘要： Provided in the disclosure is a pre-stressed concrete track slab of slab-type ballast-less track, which includes a slab body (1), on which fastening embedded casings (4) are arranged. At least one row of longitudinal common steel bars (11) and at least one row of transverse common steel bars (12) are arranged in the slab body (1) along a length direction and a width direction. The longitudinal common steel bars (11) are insulated from the transverse common steel bars (12). At least one row of longitudinal pre-stressed steel bars (7) and at least one row of transverse pre-stressed steel bars (6) are fastened in the slab body (1) along the length direction and the width direction through anchor backing plates and fastener devices (8). In the pre-stress directions of the longitudinal pre-stressed steel bars (7) and the transverse pre-stressed steel bars (6), it is post-tensioned in both directions or it is pre-tensioned in one direction and post-tensioned in the other direction. Limiting structures (5) and grounding terminals (10) are also arranged on the slab body (1). The pre-stressed concrete track slab has the characteristics of light structural dead weight, small structure height, low manufacturing cost and deformation resistance.

    摘要翻译： 本发明公开了一种板坯式无轨道预应力混凝土轨道板，包括板体（1），其上布置有紧固嵌入壳体（4）。 至少一排纵向普通钢筋（11）和至少一排横向普通钢筋（12）沿着长度方向和宽度方向布置在板坯体（1）中。 纵向普通钢筋（11）与横向普通钢筋（12）绝缘。 至少一排纵向预应力钢筋（7）和至少一排横向预应力钢筋（6）沿着长度方向和宽度方向通过锚固衬板（6）紧固在板体（1）中 和紧固件装置（8）。 在纵向预应力钢筋（7）和横向预应力钢筋（6）的预应力方向上，其沿两个方向被后张紧或者在一个方向上被预张紧并且被拉伸 在另一个方向。 限制结构（5）和接地端子（10）也布置在板体（1）上。 预应力混凝土轨道板具有结构自重轻，结构高度小，制造成本低，抗变形的特点。

    BALLASTLESS TRACK SYSTEM
    4.
    发明申请
    BALLASTLESS TRACK SYSTEM 有权
    无轨跟踪系统

    公开(公告)号：US20140203094A1

    公开(公告)日：2014-07-24

    申请号：US14342242

    申请日：2012-08-28

    申请人： Chunfang Lu ,  Youming Zhao ,  Cheng Jiang ,  Jijun Wang ,  Meng Wang ,  Yong Zhao ,  Weibin Liu ,  Ziqing Jiang ,  Ruilin You ,  Xianggang Du ,  Jia Fan

    发明人： Chunfang Lu ,  Youming Zhao ,  Cheng Jiang ,  Jijun Wang ,  Meng Wang ,  Yong Zhao ,  Weibin Liu ,  Ziqing Jiang ,  Ruilin You ,  Xianggang Du ,  Jia Fan

    IPC分类号： E01B1/00

    CPC分类号： E01B1/007 ,  E01B1/002 ,  E01B1/004 ,  E01B3/40

    摘要： A ballastless track system comprises a base; a track slab arranged above the base; a poured-field layer arranged between the base and the track slab, the poured-field layer being formed by filling self-compacting concrete, emulsified asphalt cement mortar or resin mortar, and the inside of the poured-field layer being of a steel bar structure; a connecting piece, the first end of the connecting piece extending into the track slab, and the second end of the connecting piece extending into the poured-field layer; and two rows of rail-seat arranged on the track slab in parallel; and rails arranged on the rail-seat. The ballastless track system is high in reliability, good in durability, and easy in construction and maintenance.

    摘要翻译： 无碴轨道系统包括基座; 安装在基座上方的轨道板; 浇注场层布置在基部和轨道板之间，浇注层通过填充自密实混凝土，乳化沥青水泥砂浆或树脂砂浆形成，浇注层的内部由钢筋 结构体; 连接件的第一端延伸到轨道板中，并且连接件的第二端延伸到浇注层中; 和平行排列在轨道板上的两排轨座; 和轨道布置在轨座上。 无碴轨道系统的可靠性高，耐用性好，施工维护方便。

    Antimicrobial Peptides
    5.
    发明申请
    Antimicrobial Peptides 有权
    抗菌肽

    公开(公告)号：US20110028386A1

    公开(公告)日：2011-02-03

    申请号：US12793666

    申请日：2010-06-03

    申请人： ROBERT S. HODGES ,  ZIQING JIANG

    发明人： ROBERT S. HODGES ,  ZIQING JIANG

    IPC分类号： A01N33/00 ,  C07K14/00 ,  A61K38/16 ,  A61P31/04 ,  A61P31/12 ,  A61P33/02 ,  A61P31/10

    CPC分类号： A61K38/16

    摘要： Disclosed are antimicrobial peptides with useful or superior properties such as antimicrobial activity, desirable levels of hemolysis, and advantageous therapeutic index against various microorganisms, especially Pseudomonas aeruginosa, Acinetobacter baumannii and Staphylococcus aureus. Also provided are methods of to control microbial growth and pharmaceutical compositions to treat or prevent microbial infections. Certain peptides are disclosed utilizing a structure-based rational modification of antimicrobial peptide D1, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face, or peptides with one or more amino acids in the D configuration, and peptides with all amino acids in the D configuration. Modified peptide analogs herein can demonstrate one or more properties such as improved antimicrobial activity, specificity, and resistance to degradation. Compositions disclosed herein are useful as antibiotics, including as broad spectrum antibiotics.

    摘要翻译： 公开了具有有用或优异性质的抗微生物肽，例如抗微生物活性，期望的溶血水平，以及针对各种微生物，特别是铜绿假单胞菌，鲍氏不动杆菌和金黄色葡萄球菌的有利治疗指数。 还提供了控制微生物生长和药物组合物以治疗或预防微生物感染的方法。 公开了利用基于结构的抗微生物肽D1的合理修饰，在非极性或极性表面上的肽中心附近或附近具有单个D- / L-氨基酸置换或带电残基取代的某些肽，或具有一个或多个 D构型中更多的氨基酸，以及D构型中所有氨基酸的肽。 本文中修饰的肽类似物可以证明一种或多种性质，例如改善的抗微生物活性，特异性和抗降解性。 本文公开的组合物可用作抗生素，包括作为广谱抗生素。

    PRE-STRESSED CONCRETE TRACK SLAB OF SLAB-TYPE BALLAST-LESS TRACK
    7.
    发明申请
    PRE-STRESSED CONCRETE TRACK SLAB OF SLAB-TYPE BALLAST-LESS TRACK 有权
    预应力混凝土跟踪板SLAB型不带轨道

    公开(公告)号：US20130264394A1

    公开(公告)日：2013-10-10

    申请号：US13994931

    申请日：2011-12-15

    申请人： Jijun Wang ,  Cheng Jiang ,  Weibin Liu ,  Yong Zhao ,  Meng Wang ,  Ziqing Jiang ,  Jia Fan ,  Xianggang Du

    发明人： Jijun Wang ,  Cheng Jiang ,  Weibin Liu ,  Yong Zhao ,  Meng Wang ,  Ziqing Jiang ,  Jia Fan ,  Xianggang Du

    IPC分类号： E01B1/00

    CPC分类号： E01B1/002 ,  E01B3/40

    摘要： Provided in the disclosure is a pre-stressed concrete track slab of slab-type ballast-less track, which includes a slab body (1), on which fastening embedded casings (4) are arranged. At least one row of longitudinal common steel bars (11) and at least one row of transverse common steel bars (12) are arranged in the slab body (1) along a length direction and a width direction. The longitudinal common steel bars (11) are insulated from the transverse common steel bars (12). At least one row of longitudinal pre-stressed steel bars (7) and at least one row of transverse pre-stressed steel bars (6) are fastened in the slab body (1) along the length direction and the width direction through anchor backing plates and fastener devices (8). In the pre-stress directions of the longitudinal pre-stressed steel bars (7) and the transverse pre-stressed steel bars (6), it is post-tensioned in both directions or it is pre-tensioned in one direction and post-tensioned in the other direction. Limiting structures (5) and grounding terminals (10) are also arranged on the slab body (1). The pre-stressed concrete track slab has the characteristics of light structural dead weight, small structure height, low manufacturing cost and deformation resistance.

    摘要翻译： 本发明公开了一种板坯式无轨道预应力混凝土轨道板，包括板体（1），其上布置有紧固嵌入壳体（4）。 至少一排纵向普通钢筋（11）和至少一排横向普通钢筋（12）沿着长度方向和宽度方向布置在板坯体（1）中。 纵向普通钢筋（11）与横向普通钢筋（12）绝缘。 至少一排纵向预应力钢筋（7）和至少一排横向预应力钢筋（6）沿着长度方向和宽度方向通过锚固衬板（6）紧固在板体（1）中 和紧固件装置（8）。 在纵向预应力钢筋（7）和横向预应力钢筋（6）的预应力方向上，其沿两个方向被后张紧或者在一个方向上被预张紧并且被拉伸 在另一个方向。 限制结构（5）和接地端子（10）也布置在板体（1）上。 预应力混凝土轨道板具有结构自重轻，结构高度小，制造成本低，抗变形的特点。

    Antimicrobial Peptides and Methods of Use
    8.
    发明申请
    Antimicrobial Peptides and Methods of Use 审中-公开
    抗菌肽及其使用方法

    公开(公告)号：US20100099614A1

    公开(公告)日：2010-04-22

    申请号：US12574545

    申请日：2009-10-06

    申请人： Robert S. Hodges ,  Ziqing Jiang

    发明人： Robert S. Hodges ,  Ziqing Jiang

    IPC分类号： A61K38/16 ,  C07K14/00 ,  A61P31/00 ,  A61P31/10 ,  A61P31/04 ,  A01P1/00 ,  A01N37/18

    CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/00 ,  C07K14/4723 ,  Y02A50/473 ,  Y02A50/481

    摘要： Disclosed herein are antimicrobial peptides with useful and/or superior properties such as specificity, resistance to degradation, antimicrobial activity, desirably low levels of hemolytic activity, and a therapeutic index against a broad range of microorganisms including gram-negative, gram-positive and acid-fast bacteria, fungi and other organisms. Also provided are pharmaceutical compositions comprising these peptides and methods of using such peptides to control microbial growth or to treat or reduce incidence of infections caused by such microorganisms. Also disclosed are peptides at least one or all amino acids in the D configuration. Compositions disclosed herein are useful in the treatment of bacterial, mycobacterial and/or fungal infections or for reducing microbial cell numbers or growth on surfaces or in materials.

    摘要翻译： 本文公开了具有有用和/或优异性质的抗微生物肽，例如特异性，抗降解性，抗微生物活性，期望的低溶血活性水平，以及针对宽范围微生物（包括革兰氏阴性，革兰氏阳性和酸性）的治疗指数 快速细菌，真菌等生物体。 还提供了包含这些肽的药物组合物和使用这些肽来控制微生物生长或治疗或减少由这种微生物引起的感染发生率的方法。 还公开了D构型中至少一个或所有氨基酸的肽。 本文公开的组合物可用于治疗细菌，分枝杆菌和/或真菌感染或用于减少表面或材料中的微生物细胞数量或生长。