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    Controlled release composition and method of producing the same
    1.
    发明授权
    Controlled release composition and method of producing the same 有权
    控制释放组合物及其制备方法

    公开(公告)号：US08815801B2

    公开(公告)日：2014-08-26

    申请号：US13548463

    申请日：2012-07-13

    Applicant: Kazumichi Yamamoto ,  Akiko Yamada ,  Yoshio Hata

    Inventor： Kazumichi Yamamoto ,  Akiko Yamada ,  Yoshio Hata

    IPC: A61K38/09 ,  A61K38/24

    CPC classification number: A61K38/09 ,  A61K9/1617 ,  A61K9/1647 ,  A61K38/24 ,  A61K2300/00

    Abstract: A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided. A controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weight, (2) hydroxynaphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or salt thereof, and (3) a lactic acid polymer or salt thereof having a weight-average molecular weight of 15000 to 50000 in which the content of polymers having molecular weights of 5000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxynaphthoic acid or salt thereof to said physiologically active substance or salt thereof is from 3:4 to 4:3.

    Abstract translation: 提供含有高含量的生理活性物质，抑制初始过量释放并长时间达到稳定释放速度的控释组合物。 控释组合物，其包含（1）基于总组合物重量的约14％（w / w）至约24％（w / w）的生理活性物质或其盐，（2）羟基萘甲酸 由3-羟基-2-萘甲酸和1-羟基-2-萘甲酸或其盐组成的组，和（3）重均分子量为15000〜50000的乳酸聚合物或其盐，其中 分子量为5000以下的聚合物的含量为约5重量％以下，其中所述羟基萘甲酸或其盐与所述生理活性物质或其盐的摩尔比为3:4至4:3。

    Controlled release composition and method of producing the same
    2.
    发明授权
    Controlled release composition and method of producing the same 有权
    控制释放组合物及其制备方法

    公开(公告)号：US08246987B2

    公开(公告)日：2012-08-21

    申请号：US13064282

    申请日：2011-03-16

    Applicant: Kazumichi Yamamoto ,  Akiko Yamada ,  Yoshio Hata

    Inventor： Kazumichi Yamamoto ,  Akiko Yamada ,  Yoshio Hata

    IPC: A61K38/08

    CPC classification number: A61K38/09 ,  A61K9/1617 ,  A61K9/1647 ,  A61K38/24 ,  A61K2300/00

    Abstract: A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided.A controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weight, (2) hydroxynaphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or salt thereof, and (3) a lactic acid polymer or salt thereof having a weight-average molecular weight of 15000 to 50000 in which the content of polymers having molecular weights of 5000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxynaphthoic acid or salt thereof to said physiologically active substance or salt thereof is from 3:4 to 4:3.

    Abstract translation: 提供含有高含量的生理活性物质，抑制初始过量释放并长时间达到稳定释放速度的控释组合物。 控释组合物，其包含（1）基于总组合物重量的约14％（w / w）至约24％（w / w）的生理活性物质或其盐，（2）羟基萘甲酸 由3-羟基-2-萘甲酸和1-羟基-2-萘甲酸或其盐组成的组，和（3）重均分子量为15000〜50000的乳酸聚合物或其盐，其中 分子量为5000以下的聚合物的含量为约5重量％以下，其中所述羟基萘甲酸或其盐与所述生理活性物质或其盐的摩尔比为3:4至4:3。

    PRODUCTION MANAGEMENT SYSTEM
    3.
    发明申请
    PRODUCTION MANAGEMENT SYSTEM 有权
    生产管理系统

    公开(公告)号：US20090177307A1

    公开(公告)日：2009-07-09

    申请号：US11910762

    申请日：2006-04-03

    Applicant: Katsuhisa Miyazaki ,  Shinji Kobayashi ,  Yoshio Matsuoka ,  Yoshio Hata ,  Jun Hikoe

    Inventor： Katsuhisa Miyazaki ,  Shinji Kobayashi ,  Yoshio Matsuoka ,  Yoshio Hata ,  Jun Hikoe

    IPC: G06F17/00

    CPC classification number: B25J9/1674 ,  G05B2219/40197 ,  G05B2219/40224 ,  Y02P90/14 ,  Y02P90/20

    Abstract: There is provided a production management system that requires no backup step for performing a backup operation when trouble occurs in a robot, and can increase workability of a repair operation of the robot. The production management system for a production line mixedly including robot operation steps and manual operation steps, including: a monitor that displays the cause of abnormality that occurs in the robot operation step; a warning device that warns of occurrence of abnormality in the robot operation step; and a robot reversing device that reverses the orientation of a robot when abnormality occurs in the robot, wherein production is continued by changing the robot operation step where the abnormality occurs to the manual operation step. Also, a repair operation is performed for the robot reversed by the robot reversing device.

    Abstract translation: 提供了一种生产管理系统，当机器人发生故障时，不需要执行备份操作的备份步骤，并且可以提高机器人的修复操作的可操作性。 混合生产线的生产管理系统，包括机器人操作步骤和手动操作步骤，包括：显示机器人操作步骤中出现的异常原因的监视器; 警告装置，其在所述机器人动作步骤中发生异常发生; 以及机器人逆转装置，其在机器人发生异常时使机器人的姿势反转，其中通过将进行异常的机器人操作步骤改变为手动操作步骤来继续生产。 此外，对由机器人反转装置反转的机器人执行修理操作。

    CONTROLLED RELEASE COMPOSITION AND METHOD OF PRODUCING THE SAME
    4.
    发明申请
    CONTROLLED RELEASE COMPOSITION AND METHOD OF PRODUCING THE SAME 有权
    控制释放组合物及其生产方法

    公开(公告)号：US20090005318A1

    公开(公告)日：2009-01-01

    申请号：US12181472

    申请日：2008-07-29

    Applicant: Kazumichi Yamamoto ,  Akiko Yamada ,  Yoshio Hata

    Inventor： Kazumichi Yamamoto ,  Akiko Yamada ,  Yoshio Hata

    IPC: A61K38/08 ,  A61P35/00 ,  A61K47/30

    CPC classification number: A61K38/09 ,  A61K9/1617 ,  A61K9/1647 ,  A61K38/24 ,  A61K2300/00

    Abstract: A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided.A controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weight, (2) hydroxynaphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or salt thereof, and (3) a lactic acid polymer or salt thereof having a weight-average molecular weight of 15000 to 50000 in which the content of polymers having molecular weights of 5000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxynaphthoic acid or salt thereof to said physiologically active substance or salt thereof is from 3:4 to 4:3.

    Abstract translation: 提供含有高含量的生理活性物质，抑制初始过量释放并长时间达到稳定释放速度的控释组合物。 控释组合物，其包含（1）基于总组合物重量的约14％（w / w）至约24％（w / w）的生理活性物质或其盐，（2）羟基萘甲酸 由3-羟基-2-萘甲酸和1-羟基-2-萘甲酸或其盐组成的组，和（3）重均分子量为15000〜50000的乳酸聚合物或其盐，其中 分子量为5000以下的聚合物的含量为约5重量％以下，其中所述羟基萘甲酸或其盐与所述生理活性物质或其盐的摩尔比为3:4至4:3。

    SUSTAINED RELEASE COMPOSITIONS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF
    5.
    发明申请
    SUSTAINED RELEASE COMPOSITIONS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF 审中-公开
    可持续发行组合物，其生产方法和使用方法

    公开(公告)号：US20080014237A1

    公开(公告)日：2008-01-17

    申请号：US11782707

    申请日：2007-07-25

    Applicant: Yasutaka Igari ,  Yoshio Hata ,  Kazumichi Yamamoto

    Inventor： Yasutaka Igari ,  Yoshio Hata ,  Kazumichi Yamamoto

    IPC: A61K9/00 ,  A61K38/02 ,  A61K38/09 ,  A61K47/12

    CPC classification number: A61K9/1647 ,  A61K9/0024 ,  A61K9/1617

    Abstract: Sustained release compositions containing a physiologically active substance or its salt, hydroxynaphthoic acid or its salt and a lactic acid-glycolic polymer or its salt, wherein the product of the weight-average molecular weight of the lactic acid-glycolic acid polymer by the amount (μmol) of the terminal carboxyl group per unit mass (g) of the lactic acid-glycolic acid polymer is from 1,200,000 to 3,000,000 (inclusive); and their production; medicaments containing these sustained release compositions, etc.

    Abstract translation: 含有生理活性物质或其盐，羟基萘甲酸或其盐和乳酸 - 乙醇酸聚合物或其盐的缓释组合物，其中乳酸 - 乙醇酸聚合物的重均分子量乘以（ 乳酸 - 乙醇酸聚合物的单位质量（g）的末端羧基的摩尔数为1,200,000〜300万以上） 和他们的生产; 含有这些缓释组合物的药物等

    Sustained release compositions, process for producing the same and use thereof
    6.
    发明授权
    Sustained release compositions, process for producing the same and use thereof 失效
    缓释组合物，其制备方法及其用途

    公开(公告)号：US07265157B1

    公开(公告)日：2007-09-04

    申请号：US10019786

    申请日：2000-07-13

    Applicant: Yasutaka Igari ,  Yoshio Hata ,  Kazumichi Yamamoto

    Inventor： Yasutaka Igari ,  Yoshio Hata ,  Kazumichi Yamamoto

    IPC: A61K47/12 ,  A61K38/00

    CPC classification number: A61K9/1647 ,  A61K9/0024 ,  A61K9/1617

    Abstract: Sustained release compositions containing a physiologically active substance or its salt, hydroxynaphthoic acid or its salt and a lactic acid-glycolic polymer or its salt, wherein the product of the weight-average molecular weight of the lactic acid-glycolic acid polymer by the amount (μmol) of the terminal carboxyl group per unit mass (g) of the lactic acid-glycolic acid polymer is from 1,200,000 to 3,000,000 (inclusive); and their production; medicaments containing these sustained release compositions, etc.

    Abstract translation: 含有生理活性物质或其盐，羟基萘甲酸或其盐和乳酸 - 乙醇酸聚合物或其盐的缓释组合物，其中乳酸 - 乙醇酸聚合物的重均分子量乘以（ 乳酸 - 乙醇酸聚合物的单位质量（g）的末端羧基的摩尔数为1,200,000〜300万以上） 和他们的生产; 含有这些缓释组合物的药物等

    Sustained-release composition and process for producing the same
    8.
    发明授权
    Sustained-release composition and process for producing the same 有权
    缓释组合物及其制备方法

    公开(公告)号：US08258252B2

    公开(公告)日：2012-09-04

    申请号：US11960114

    申请日：2007-12-19

    Applicant: Kazumichi Yamatomo ,  Akiko Yamada ,  Yoshio Hata

    Inventor： Kazumichi Yamatomo ,  Akiko Yamada ,  Yoshio Hata

    IPC: C08G67/00

    CPC classification number: A61K38/09 ,  A61K9/1647

    Abstract: Present invention is to provide a sustained-release composition which contains a physiologically active substance in high content even when gelatin is not included, and suppresses its initial excessive release and, thus, can achieve a stable release rate over about one month. A sustained-release composition containing a lactic acid-glycolic acid polymer having a ratio or weight average molecular weight and number average molecular weight of about 1.90 or lower, or a salt thereof, and a physiologically active substance.

    Abstract translation: 本发明提供即使在不含明胶时也含有高含量的生理活性物质的缓释组合物，抑制其初始过度释放，从而能够在约1个月内达到稳定的释放速度。 一种缓释组合物，其含有比例或重均分子量和数均分子量为约1.90以下的乳酸 - 乙醇酸聚合物或其盐和生理活性物质。

    Controlled release composition and method of producing the same
    9.
    发明申请
    Controlled release composition and method of producing the same 有权

    公开(公告)号：US20110166084A1

    公开(公告)日：2011-07-07

    申请号：US13064282

    申请日：2011-03-16

    Applicant: Kazumichi Yamamoto ,  Akiko Yamada ,  Yoshio Hata

    Inventor： Kazumichi Yamamoto ,  Akiko Yamada ,  Yoshio Hata

    IPC: A61K38/08 ,  A61K47/34 ,  A61P35/00

    CPC classification number: A61K38/09 ,  A61K9/1617 ,  A61K9/1647 ,  A61K38/24 ,  A61K2300/00

    Abstract: A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided.A controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weight, (2) hydroxynaphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or salt thereof, and (3) a lactic acid polymer or salt thereof having a weight-average molecular weight of 15000 to 50000 in which the content of polymers having molecular weights of 5000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxynaphthoic acid or salt thereof to said physiologically active substance or salt thereof is from 3:4 to 4:3.

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