公开(公告)号：US20060222594A1

公开(公告)日：2006-10-05

申请号：US11334957

申请日：2006-01-19

Applicant: Seung-Jun Lee ,  Bong-Sik Jeon ,  Jong-Duk Kim ,  Yong-Min Hur ,  Ho-Taek Song ,  Jin-Suck Suh

Inventor： Seung-Jun Lee ,  Bong-Sik Jeon ,  Jong-Duk Kim ,  Yong-Min Hur ,  Ho-Taek Song ,  Jin-Suck Suh

IPC: A61K49/10 ,  C07K16/46

CPC classification number: A61K49/1857 ,  A61K9/0009 ,  A61K9/143 ,  B82Y5/00

Abstract: Disclosed are a targeting magnetic nanosphere preparation capable of diagnosing and treating tumors in mammals and a method of manufacturing the same. The smart magnetic nanosphere preparation contains magnetic nano-sized iron oxide nanoparticles, which can be detected by magnetic resonance imaging (MRI), as a core material. The core material is encapsulated in a size of tens to hundreds of nanometers allowing particles to penetrate into deep areas of biological tissues using a biodegradable polymer having high affinity for biological tissues. The formed capsules are surface-modified with an antibody specific to a specific tumor. The smart magnetic nanosphere preparation can effectively diagnose tumors, as well as treat tumors because it has an antibody to a specific tumor.

Abstract translation: 公开了能够诊断和治疗哺乳动物肿瘤的靶向磁性纳米球制剂及其制造方法。 智能磁纳米球制备包含磁性纳米尺寸的氧化铁纳米颗粒，可以通过磁共振成像（MRI）作为核心材料进行检测。 核心材料被封装成数十至数百纳米的尺寸，允许使用对生物组织具有高亲和力的可生物降解聚合物使颗粒渗入生物组织的深部区域。 形成的胶囊用特异性肿瘤特异的抗体进行表面修饰。 智能磁性纳米球制剂可以有效诊断肿瘤，以及治疗肿瘤，因为它具有针对特定肿瘤的抗体。