公开(公告)号：US20240262930A1

公开(公告)日：2024-08-08

申请号：US18561413

申请日：2022-05-27

Applicant: XYONE THERAPEUTICS INC. ,  DANA-FARBER CANCER INSTITUTE, INC.

Inventor： Surender KHARBANDA ,  Govindaswamy PANCHAMOORTHY ,  Donald W. KUFE

IPC: C07K16/30 ,  A61K45/06 ,  A61K47/68 ,  A61K47/69 ,  A61P35/02 ,  C07K16/28 ,  C07K16/32

CPC classification number: C07K16/3092 ,  A61K45/06 ,  A61K47/6849 ,  A61K47/6889 ,  A61K47/6913 ,  A61P35/02 ,  C07K16/2809 ,  C07K16/2818 ,  C07K16/283 ,  C07K16/2851 ,  C07K16/2863 ,  C07K16/2896 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/734

Abstract: The present disclosure is directed to multispecific antibody constructs binding to MUC1-C/extracellular domain (MUC1-C/ECD) and to at least’ one other binding target, wherein the binding target comprising CD3 (cluster of differentiation 3). Also provided are methods of using such constructs to treat cancers that express the MUC1 antigen. Further disclosed are sequences of recombinant multispecific antibodies.

公开(公告)号：US20230265208A1

公开(公告)日：2023-08-24

申请号：US18005562

申请日：2021-07-15

Applicant: DANA-FARBER CANCER INSTITUTE, INC. ,  XYONE THERAPEUTICS, INC.

Inventor： Surender KHARBANDA ,  Donald W. KUFE

IPC: C07K16/30

CPC classification number: C07K16/3092 ,  C07K2317/565 ,  C07K2317/55 ,  C07K2317/24 ,  C07K2317/53

Abstract: The present disclosure is directed to antibodies binding to MUC1-C/extracellular domain (MUC1-C/ECD) and methods of using such antibodies to treat cancers that express the MUC1 antigen.