公开(公告)号：US20120270821A1

公开(公告)日：2012-10-25

申请号：US13513744

申请日：2010-12-07

申请人： Nancy Yuk-Yu IP ,  Fanny Chui-Fun IP ,  Wing Yu Fu ,  Guangmiao Fu

发明人： Nancy Yuk-Yu IP ,  Fanny Chui-Fun IP ,  Wing Yu Fu ,  Guangmiao Fu

IPC分类号： A61K31/7028 ,  A61K31/7048 ,  A61K31/352 ,  A61K31/192 ,  A61P29/00 ,  A61K31/7034 ,  A61P25/08 ,  A61P25/28 ,  A61P25/16 ,  A61P25/14 ,  C12N9/99 ,  A61K31/353 ,  C07H15/18 ,  A61P25/00

CPC分类号： A61K31/7048 ,  A61K31/19 ,  A61K31/352 ,  A61K31/353 ,  A61K31/7004 ,  A61K31/7016 ,  A61K36/41 ,  C07D311/62 ,  C07H15/10

摘要： Natural occurring inhibitors of cyclin-dependent protein kinase 5 (Cdk5), isolated from the root of Rhodiola rosea are structurally different from the known Cdk inhibitors. They show selectivity among different Cdks and efficacy to inhibit Cdk via a mixed-type of inhibition, which should lead to less toxicity and side-effects. They are useful in preventing and treating diseases and disorders associated with aberrant Cdk5 activities, such as acute and/or chronic pain, neuropathic pain, diabetes mellitus, cancer, neurodegenerative diseases and neuropathological disorders.

摘要翻译： 从红景天根分离的细胞周期蛋白依赖性蛋白激酶5（Cdk5）的天然存在的抑制剂在结构上不同于已知的Cdk抑制剂。 它们显示不同CdS的选择性和通过混合型抑制抑制Cdk的功效，其应该导致较少的毒性和副作用。 它们可用于预防和治疗与异常的Cdk5活性相关的疾病和病症，例如急性和/或慢性疼痛，神经性疼痛，糖尿病，癌症，神经变性疾病和神经病理学障碍。