发明申请
- 专利标题： CDK5 Inhibitors and Therapeutic Uses Thereof
- 专利标题（中）： CDK5抑制剂及其治疗用途
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申请号： US13513744申请日： 2010-12-07
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公开(公告)号： US20120270821A1公开(公告)日： 2012-10-25
- 发明人: Nancy Yuk-Yu IP , Fanny Chui-Fun IP , Wing Yu Fu , Guangmiao Fu
- 申请人： Nancy Yuk-Yu IP , Fanny Chui-Fun IP , Wing Yu Fu , Guangmiao Fu
- 申请人地址： CN Hong Kong
- 专利权人： The Hong Kong University of Science and Technology
- 当前专利权人： The Hong Kong University of Science and Technology
- 当前专利权人地址： CN Hong Kong
- 国际申请： PCT/CN2010/001982 WO 20101207
- 主分类号： A61K31/7028
- IPC分类号： A61K31/7028 ; A61K31/7048 ; A61K31/352 ; A61K31/192 ; A61P29/00 ; A61K31/7034 ; A61P25/08 ; A61P25/28 ; A61P25/16 ; A61P25/14 ; C12N9/99 ; A61K31/353 ; C07H15/18 ; A61P25/00
摘要：
Natural occurring inhibitors of cyclin-dependent protein kinase 5 (Cdk5), isolated from the root of Rhodiola rosea are structurally different from the known Cdk inhibitors. They show selectivity among different Cdks and efficacy to inhibit Cdk via a mixed-type of inhibition, which should lead to less toxicity and side-effects. They are useful in preventing and treating diseases and disorders associated with aberrant Cdk5 activities, such as acute and/or chronic pain, neuropathic pain, diabetes mellitus, cancer, neurodegenerative diseases and neuropathological disorders.
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