公开(公告)号：US5673686A

公开(公告)日：1997-10-07

申请号：US382428

申请日：1995-02-02

申请人： Peter Villax ,  Rui Peres ,  William Richard Treneman ,  Iain Grierson McDerment ,  Martin Bunce

发明人： Peter Villax ,  Rui Peres ,  William Richard Treneman ,  Iain Grierson McDerment ,  Martin Bunce

IPC分类号： A61M13/00 ,  A61M15/00 ,  A61M16/00 ,  B05D3/00 ,  A61M15/08

CPC分类号： A61M15/0028 ,  A61M15/0038 ,  A61M2202/064

摘要： A new inhalation device, which during operation causes an aerosol to be formed inside a chamber such as a capsule (4) which occludes one end (3) of the inhalation tube (1), the capsule having holes at its extremities (7,8) which admit airflow. The airflow causes the powder contained inside the capsule to be surprisingly transported to the capsule extremity contrary to the direction of inhalation, that is towards the air entry holes in the capsule, and then to form an aerosol until all powder has been removed from the capsule or chamber through the tube (1), the during of inhalation being chiefly regulated by the size and proportion of the capsule holes. The tube (1) has air inlets downstream of the capsule to permit a balanced airflow that will transport the finely suspended powder into the lungs, maximizing the fraction of medicament deposited therein.

摘要翻译： 一种新的吸入装置，其在操作期间引起气泡形成在诸如封闭吸入管（1）的一端（3）的胶囊（4）的腔室内，所述胶囊在其末端具有孔（7,8 ）允许气流。 气流使得容纳在胶囊内的粉末能够令人惊讶地与吸入方向相反地输送到胶囊末端，即朝向胶囊中的空气进入孔，然后形成气溶胶，直到所有粉末从胶囊中移出 或通过管（1）的腔室，吸入期间主要由胶囊孔的尺寸和比例来调节。 管（1）具有在胶囊下游的空气入口，以允许平衡的气流，其将精细悬浮的粉末输送到肺中，使其中沉积的药物的分数最大化。

公开(公告)号：US06446627B1

公开(公告)日：2002-09-10

申请号：US09319947

申请日：1999-10-22

申请人： Nicholas John Bowman ,  Michael John Holroyd ,  Costaninos Panayi ,  William Richard Treneman

发明人： Nicholas John Bowman ,  Michael John Holroyd ,  Costaninos Panayi ,  William Richard Treneman

IPC分类号： A61M1100

CPC分类号： A61M15/009 ,  A61M15/0068 ,  A61M15/0078 ,  G06M1/083 ,  G06M1/22 ,  G06M1/246

摘要： A dose counter for a metered dose inhaler comprises actuator means (341), drive means (350) for driving a rotary gear (360) in step-wise fashion in response to displacement of said actuator means (341), said rotary gear (360) comprising a wheel having a plurality of ratchet teeth (not shown) around its periphery. Means (364) are provided to prevent reverse rotation of the rotary gear (360). A flexible tape (368) is provided with a visible array of incrementing integers on its surface indicating the number of medicament doses remaining in the inhaler. The tape (368) indexes by a single integer in response to each step of the step-wise rotary motion of the rotary gear (360). A control surface (371) regulates the position of engagement and disengagement between the drive means (350) and the rotary gear (360). In an alternative embodiment (FIG. 6), the control surface (371) is omitted and the means for preventing reverse rotation comprise a stepless restraint (664).

摘要翻译： 用于计量剂量吸入器的剂量计数器包括致动器装置（341），用于响应于所述致动器装置（341）的位移而逐步地驱动旋转齿轮（360）的驱动装置（350），所述旋转齿轮（360） ）包括围绕其周边具有多个棘轮齿（未示出）的轮。 提供装置（364）以防止旋转齿轮（360）的反向旋转。 柔性带（368）在其表面上设置有可见的递增整数阵列，指示吸入器中剩余的药物剂量的数量。 响应于旋转齿轮（360）的逐步旋转运动的每个步骤，带（368）由单个整数索引。 控制表面（371）调节驱动装置（350）和旋转齿轮（360）之间的接合和分离的位置。 在替代实施例（图6）中，省略了控制表面（371），并且用于防止反向旋转的装置包括无级限制（664）。