公开(公告)号：US07350403B2

公开(公告)日：2008-04-01

申请号：US11098220

申请日：2005-04-04

Applicant: Tatjana Anatoljevna Yakhno ,  Anatoly Gennadievich Sanin ,  Vladimir Grigorievich Yakhno ,  Artem S. Pelushenko ,  Olga S. Shapovnikova ,  Michael B. Dowell ,  Christina V. Vacca ,  Valentina B. Goutorova

Inventor： Tatjana Anatoljevna Yakhno ,  Anatoly Gennadievich Sanin ,  Vladimir Grigorievich Yakhno ,  Artem S. Pelushenko ,  Olga S. Shapovnikova ,  Michael B. Dowell ,  Christina V. Vacca ,  Valentina B. Goutorova

IPC: G01N29/00

CPC classification number: G01N29/028 ,  G01N11/16 ,  G01N29/022 ,  G01N29/032 ,  G01N29/4436 ,  G01N29/48 ,  G01N33/02 ,  G01N33/04 ,  G01N33/14 ,  G01N2035/1046 ,  G01N2203/0094 ,  G01N2291/014 ,  G01N2291/015 ,  G01N2291/018 ,  G01N2291/022 ,  G01N2291/024 ,  G01N2291/02466 ,  G01N2291/0251 ,  G01N2291/0258 ,  G01N2291/02827 ,  G01N2291/0421 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0427 ,  G01N2291/048 ,  G01N2291/101

Abstract: A method for analysis of a multi-component fluid is provided based on the features of the dynamics of the self-organization processes in drying drops. An electro-acoustic resonator is utilized, with a drop of multi-component fluid placed on one end of the resonator. A shear oscillation is imparting to the resonator along its longitudinal axis. And oscillating electric voltage is placed across the resonator generally perpendicular to the direction of mechanical oscillation. Changes in the electrical conductance corresponding to changes in the acoustical-mechanical impedance can thereby be measured as the drop of multi-component liquid dries. The particular geometry of an amplitude curve includes identifying the spatio-temporal development and phase transitions is used for integral estimation of food authenticity and quality.

Abstract translation: 基于干燥液滴中自组织过程的动态特征提供了一种多组分流体分析方法。 使用电声谐振器，一滴多分量流体放置在谐振器的一端。 剪切振荡沿着其纵轴赋予谐振器。 并且振荡电压跨越谐振器放置在垂直于机械振荡的方向上。 因此，可以随着多组分液体干燥的下降来测量与声 - 机械阻抗变化相对应的电导率的变化。 幅度曲线的特定几何包括识别时空发展，相位转换用于食品真实性和质量的整体估计。

公开(公告)号：US07350402B2

公开(公告)日：2008-04-01

申请号：US11098219

申请日：2005-04-04

Applicant: Tatjana Anatoljevna Yakhno ,  Anatoly Gennadievich Sanin ,  Vladimir Grigorievich Yakhno ,  Artem S. Pelushenko ,  Michael B. Dowell ,  Christina V. Vacca ,  Valentina B. Goutorova

Inventor： Tatjana Anatoljevna Yakhno ,  Anatoly Gennadievich Sanin ,  Vladimir Grigorievich Yakhno ,  Artem S. Pelushenko ,  Michael B. Dowell ,  Christina V. Vacca ,  Valentina B. Goutorova

IPC: G01N29/00

CPC classification number: G01N29/48 ,  G01N29/028 ,  G01N29/032 ,  G01N33/02 ,  G01N33/04 ,  G01N33/14 ,  G01N2203/0094 ,  G01N2291/02466 ,  G01N2291/0258 ,  G01N2291/02827 ,  G01N2291/0421 ,  G01N2291/0422

Abstract: A method for measuring changes in the composition of fluids, for medical diagnostics or quality control of fluids, comprising: One) placing a drop of fluid upon a quartz crystal; Two) generating ultrasonic vibrations of a predetermined frequency in the crystal; with the vibrating wave directed into the drop of fluid in a vertical direction relative to the area of the crystal upon which the drop is placed; Three) measuring voltage changes over a bridge circuit connected to the crystal, over a time period during which total or partial evaporation of the liquid occurs; Four) comparing the measurement result to previously obtained results or to predetermined data; Five) detecting changes in the composition of the fluid, from the results. detecting changes in the composition of the fluid, from said results.

Abstract translation: 一种用于测量流体组成，用于医疗诊断或流体质量控制的变化的方法，包括：1）将一滴液体放置在石英晶体上; 二）在晶体中产生预定频率的超声波振动; 其中所述振动波相对于放置所述液滴的所述晶体的区域在垂直方向上引导到所述液滴中; 三个）测量连接到晶体的桥接电路上的电压变化，在此期间发生液体的全部或部分蒸发; 四）将测量结果与先前获得的结果或预定数据进行比较; 五）从结果中检测流体组成的变化。 从所述结果检测流体的组成的变化。

公开(公告)号：US06874357B2

公开(公告)日：2005-04-05

申请号：US10466845

申请日：2002-08-01

Applicant: Tatjana Anatoljevna Yakhno ,  Vladimir Grigorievich Yakhno ,  Ivan Ivanovich Shmeljov ,  Anatoly Gennadievich Sanin ,  Evgeny Valerievich Krotov ,  Yuri Yakovievich Brodsky

Inventor： Tatjana Anatoljevna Yakhno ,  Vladimir Grigorievich Yakhno ,  Ivan Ivanovich Shmeljov ,  Anatoly Gennadievich Sanin ,  Evgeny Valerievich Krotov ,  Yuri Yakovievich Brodsky

IPC: G01N11/16 ,  G01N29/02 ,  G01N29/028 ,  G01N29/44 ,  G01N35/10 ,  G01N29/00

CPC classification number: G01N29/4436 ,  G01N11/16 ,  G01N29/022 ,  G01N2035/1046 ,  G01N2291/014 ,  G01N2291/015 ,  G01N2291/018 ,  G01N2291/022 ,  G01N2291/024 ,  G01N2291/02466 ,  G01N2291/0251 ,  G01N2291/0258 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0427 ,  G01N2291/048 ,  G01N2291/101

Abstract: The present invention relates to physical chemistry and can be used for a quality test of liquids, in particular, multi-component liquid products, to ascertain the conformity of various process liquids, pharmaceutical preparations, foodstuffs, biological liquids to standard in pharmacology, food processing and chemical industries, and in medical diagnostics. The method of invention enables determining of the mechanical impedance within a drop (1) of test liquid having a specified volume, in the preferred embodiment, 5 mcl, placed on the surface of a piezoelectric resonator (3) of ultrasound frequencies, which provides for excitation of shear modes within drop (1) while it is drying up. The obtained time dependence of the mechanical impedance of drop (1) is used as the information parameter. This information parameter is rather sensitive to the state of the liquid-crystalline structure of multi-component liquids, therefore, comparing the obtained time dependence with the same data for the etalon specimen allows one to assess the composition of a multi-component liquid, test the quality of liquid products, for example, foodstuffs, assess the prospective effectiveness of medical treatment with various medical preparations through analysis of a biological liquid, etc.In the apparatus of invention, the mechanical impedance of test liquid is determined from the disbalance voltage of a bridge circuit (9) comprising a piezoelectric resonator of ultrasound frequencies (3), in preferred embodiments, from the amplitude and/or phase of the disbalance voltage, which ensures high accuracy of measurements.

Abstract translation: 本发明涉及物理化学，并且可以用于液体，特别是多组分液体产品的质量测试，以确定各种工艺液体，药物制剂，食品，生物液体与药理学标准，食品加工 化学工业和医疗诊断。 本发明的方法使得能够确定放置在超声频率的压电谐振器（3）的表面上的具有指定体积的测试液体的液滴（1）中的机械阻抗，该特定体积在优选实施例中为5mcl，其提供 在干燥期间在液滴（1）内激发剪切模式。 所获得的液滴（1）的机械阻抗的时间依赖性被用作信息参数。 该信息参数对多组分液体的液晶结构的状态相当敏感，因此，将获得的时间依赖性与标准具样品的相同数据进行比较允许评估多组分液体的组成，测试 液体产品，例如食品的质量，通过分析生物液体等来评估各种药物制剂的医疗前景效果。在本发明的装置中，测试液体的机械阻抗由不平衡电压 在优选实施例中，包括超声波频率（3）的压电谐振器的桥接电路（9），来自所述不平衡电压的幅度和/或相位，这确保了测量的高精度。