公开(公告)号：US20200231620A1

公开(公告)日：2020-07-23

申请号：US16648146

申请日：2018-09-17

申请人： Keith Andrew BOWMAN ,  Chandra VARGEESE ,  David Charles Donnell BUTLER ,  Pachamuthu KANDASAMY ,  Mohammed Rowshon ALAM ,  Mamoru SHIMIZU ,  Stephany Michelle STANDLEY ,  Vincent ADUDA ,  Gopal Reddy BOMMINENI ,  Snehlata TRIPATHI ,  Ilia KORBOUKH ,  WAVE LIFE SCIENCES LTD.

发明人： Keith Andrew Bowman ,  Chandra Vargeese ,  David Charles Donnell Butler ,  Pachamuthu Kandasamy ,  Mohammed Rowshon Alam ,  Mamoru Shimizu ,  Stephany Michelle Standley ,  Vincent Aduda ,  Gopal Reddy Bommineni ,  Snehlata Tripathi ,  Ilia Korboukh

IPC分类号： C07H21/02 ,  C07H21/04

摘要： Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.