公开(公告)号：US20120076728A1

公开(公告)日：2012-03-29

申请号：US13263069

申请日：2010-04-07

Applicant: Anna M. Wu ,  Vania E. Kenanova ,  Tove Olafsen

Inventor： Anna M. Wu ,  Vania E. Kenanova ,  Tove Olafsen

IPC: A61K38/38 ,  A61K49/00 ,  A61P35/00 ,  C12N9/96 ,  C07K19/00 ,  A61K51/08 ,  B82Y5/00 ,  B82Y15/00

CPC classification number: C07K14/765 ,  A61K38/00 ,  A61K47/61 ,  A61K47/6889 ,  A61K51/1048 ,  C07K16/42 ,  C07K19/00 ,  C07K2319/30 ,  C07K2319/33 ,  C12N15/115 ,  C12N2310/16

Abstract: This invention provides constructs comprising a protein scaffold, wherein the scaffold comprises Domain III, Domain IIIa, or Domain IIIb of human serum albumin or a polypeptide having substantial sequence identity to the Domain III, the Domain IIIa, or the Domain IIIb; and a targeting moiety in covalent linkage to the protein scaffold; and a therapeutic moiety and/or an imaging moiety in covalent linkage to the protein scaffold. The scaffold can be modified to tune the serum pharmacokinetics of the construct. In addition to methods of making the constructs, therapeutic, imaging and diagnostic uses of the constructs are also provided.

Abstract translation: 本发明提供了包含蛋白质支架的构建体，其中所述支架包含人血清白蛋白的III区，IIIa区或IIIb区，或与III，Domain IIIa或Domain IIIb具有实质序列同一性的多肽; 和与蛋白质支架共价连接的靶向部分; 和与蛋白质支架共价连接的治疗部分和/或成像部分。 可以修饰支架以调节构建体的血清药代动力学。 除了制备构建体的方法之外，还提供了构建体的治疗，成像和诊断用途。