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公开(公告)号：US09408825B2
公开(公告)日：2016-08-09
申请号：US14810117
申请日：2015-07-27
IPC分类号： A61K31/352 , A23L1/30 , A61K31/35 , A61K31/353
CPC分类号： A61K31/353 , A23L33/10 , A23V2002/00 , A61K8/498 , A61K9/0014 , A61K9/0053 , A61K31/35 , A61K31/352 , A61Q7/00 , A61Q19/08
摘要： Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes.
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公开(公告)号：US08668914B2
公开(公告)日：2014-03-11
申请号：US12533169
申请日：2009-07-31
摘要： Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies of skin and hair. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes affecting skin and hair.
摘要翻译： 洋甘菊（7-羟基-3（4'-羟基苯基） - 苯并二氢吡喃）是植物雌激素黄豆苷元的主要代谢物，在体外和体内特异性结合并阻断5α-二氢睾酮（DHT）的激素作用。 Equol可以结合循环的自由DHT并将其从雄激素受体中隔离，从而改变由雄激素调节的生长和生理激素反应。 这些数据表明了一种解释牛尿酚生物学特性的新模型。 雌激素特异性结合并从雄激素受体中螯合DHT的能力的意义在健康和疾病中具有重要的影响，并且可能表明在治疗和预防雄激素介导的皮肤和头发病理学中雌马酚的广泛和重要的用途。 因此，雌马酚可以特异性结合DHT并防止DHT在影响皮肤和头发的生理和病理生理过程中的生物学作用。
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公开(公告)号：US08450364B2
公开(公告)日：2013-05-28
申请号：US13442466
申请日：2012-04-09
IPC分类号： A61K31/35
CPC分类号： A61K31/353 , A23L33/10 , A23V2002/00 , A61K8/498 , A61K9/0014 , A61K9/0053 , A61K31/35 , A61K31/352 , A61Q7/00 , A61Q19/08
摘要： Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes.
摘要翻译： 洋甘菊（7-羟基-3（4'-羟基苯基） - 苯并二氢吡喃）是植物雌激素黄豆苷元的主要代谢物，特异性结合并阻断5α-二氢睾酮（DHT）在体外和体内的激素作用。 Equol可以结合循环的自由DHT并将其从雄激素受体中隔离，从而改变由雄激素调节的生长和生理激素反应。 这些数据表明了一种解释牛尿酚生物学特性的新模型。 雌激素特异性结合并从雄激素受体中螯合DHT的能力的意义在健康和疾病中具有重要的影响，并且可能表明在治疗和预防雄激素介导的病理学中雌马酚的广泛和重要用途。 因此，雌马酚可以特异性结合DHT并防止DHT在生理和病理生理过程中的生物学作用。
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4.发明授权Use of equol for ameliorating or preventing neuropsychiatric and neurodegenerative diseases or disorders 有权使用牛尿酚来改善或预防神经精神和神经退行性疾病或障碍公开(公告)号：US08580846B2
公开(公告)日：2013-11-12
申请号：US11506443
申请日：2006-08-18
CPC分类号： A61K31/353 , A61K31/35
摘要： The invention is directed to a method of preventing or ameliorating a neuropsychiatric or neurodegenerative disease or disorder in a subject. The method includes administering a composition comprising equol in an amount sufficient to prevent or ameliorate the neuropsychiatric or neurodegenerative disease or disorder. The equol may be a racemic mixture of R-equol and S-equol. The equol may be enantiomerically enriched with R-equol or enantiomerically enriched with S-equol.
摘要翻译： 本发明涉及一种在受试者中预防或改善神经精神障碍或神经变性疾病或病症的方法。 该方法包括给予含有足以防止或改善神经精神障碍或神经变性疾病或病症的量的含有牛尿酚的组合物。 雌马酚可以是R-牛尿酚和S-牛尿酚的外消旋混合物。 雌马酚可以对映异构体富含R-牛尿酚或对映体富含S-牛尿酚。
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公开(公告)号：US20100076071A1
公开(公告)日：2010-03-25
申请号：US12533169
申请日：2009-07-31
IPC分类号： A61K31/352 , A61P5/26
摘要： Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies of skin and hair. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes affecting skin and hair.
摘要翻译： 洋甘菊（7-羟基-3（4'-羟基苯基） - 苯并二氢吡喃）是植物雌激素黄豆苷元的主要代谢物，在体外和体内特异性结合和阻断5α-二氢睾酮（DHT）的激素作用。 Equol可以结合循环的自由DHT并将其从雄激素受体中隔离，从而改变由雄激素调节的生长和生理激素反应。 这些数据表明了一种解释牛尿酚生物学特性的新模型。 雌激素特异性结合并从雄激素受体中螯合DHT的能力的意义在健康和疾病中具有重要的影响，并且可能表明在治疗和预防雄激素介导的皮肤和头发病理学中雌马酚的广泛和重要的用途。 因此，雌马酚可以特异性结合DHT并防止DHT在影响皮肤和头发的生理和病理生理过程中的生物学作用。
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公开(公告)号：US09889116B2
公开(公告)日：2018-02-13
申请号：US15065344
申请日：2016-03-09
IPC分类号： A61K31/353 , A61K8/49 , A61K9/00 , A61K31/35 , A61K31/352 , A61Q7/00 , A61Q19/08 , A23L33/10
CPC分类号： A61K31/353 , A23L33/10 , A23V2002/00 , A61K8/498 , A61K9/0014 , A61K9/0053 , A61K31/35 , A61K31/352 , A61Q7/00 , A61Q19/08
摘要： Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes.
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公开(公告)号：US20140135387A1
公开(公告)日：2014-05-15
申请号：US13903748
申请日：2013-05-28
IPC分类号： A61K31/352
CPC分类号： A61K31/353 , A23L33/10 , A23V2002/00 , A61K8/498 , A61K9/0014 , A61K9/0053 , A61K31/35 , A61K31/352 , A61Q7/00 , A61Q19/08
摘要： Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes.
摘要翻译： 洋甘菊（7-羟基-3（4'-羟基苯基） - 苯并二氢吡喃）是植物雌激素黄豆苷元的主要代谢物，在体外和体内特异性结合和阻断5α-二氢睾酮（DHT）的激素作用。 Equol可以结合循环的自由DHT并将其从雄激素受体中隔离，从而改变由雄激素调节的生长和生理激素反应。 这些数据表明了一种解释牛尿酚生物学特性的新模型。 雌激素特异性结合并从雄激素受体中螯合DHT的能力的意义在健康和疾病中具有重要的影响，并且可能表明在治疗和预防雄激素介导的病理学中雌马酚的广泛和重要用途。 因此，雌马酚可以特异性结合DHT并防止DHT在生理和病理生理过程中的生物学作用。
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公开(公告)号：US08153684B2
公开(公告)日：2012-04-10
申请号：US12572791
申请日：2009-10-02
IPC分类号： A61K31/35
CPC分类号： A61K31/353 , A23L33/10 , A23V2002/00 , A61K8/498 , A61K9/0014 , A61K9/0053 , A61K31/35 , A61K31/352 , A61Q7/00 , A61Q19/08
摘要： Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes.
摘要翻译： 洋甘菊（7-羟基-3（4'-羟基苯基） - 苯并二氢吡喃）是植物雌激素黄豆苷元的主要代谢物，在体外和体内特异性结合和阻断5α-二氢睾酮（DHT）的激素作用。 Equol可以结合循环的自由DHT并将其从雄激素受体中隔离，从而改变由雄激素调节的生长和生理激素反应。 这些数据表明了一种解释牛尿酚生物学特性的新模型。 雌激素特异性结合并从雄激素受体中螯合DHT的能力的意义在健康和疾病中具有重要的影响，并且可能表明在治疗和预防雄激素介导的病理学中雌马酚的广泛和重要用途。 因此，雌马酚可以特异性结合DHT并防止DHT在生理和病理生理过程中的生物学作用。
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公开(公告)号：US20160256436A1
公开(公告)日：2016-09-08
申请号：US15065344
申请日：2016-03-09
IPC分类号： A61K31/353 , A61K9/00 , A61K8/49 , A61Q19/08 , A61Q7/00
CPC分类号： A61K31/353 , A23L33/10 , A23V2002/00 , A61K8/498 , A61K9/0014 , A61K9/0053 , A61K31/35 , A61K31/352 , A61Q7/00 , A61Q19/08
摘要： Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes.
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公开(公告)号：US09089547B2
公开(公告)日：2015-07-28
申请号：US13903748
申请日：2013-05-28
IPC分类号： A61K31/352 , A61K31/35 , A61K31/353
CPC分类号： A61K31/353 , A23L33/10 , A23V2002/00 , A61K8/498 , A61K9/0014 , A61K9/0053 , A61K31/35 , A61K31/352 , A61Q7/00 , A61Q19/08
摘要： Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes.
摘要翻译： 洋甘菊（7-羟基-3（4'-羟基苯基） - 苯并二氢吡喃）是植物雌激素黄豆苷元的主要代谢物，在体外和体内特异性结合和阻断5α-二氢睾酮（DHT）的激素作用。 Equol可以结合循环的自由DHT并将其从雄激素受体中隔离，从而改变由雄激素调节的生长和生理激素反应。 这些数据表明了一种解释牛尿酚生物学特性的新模型。 雌激素特异性结合并从雄激素受体中螯合DHT的能力的意义在健康和疾病中具有重要的影响，并且可能表明在治疗和预防雄激素介导的病理学中雌马酚的广泛和重要用途。 因此，雌马酚可以特异性结合DHT并防止DHT在生理和病理生理过程中的生物学作用。
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