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    QUINAZOLIN-4-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    1.
    发明申请
    QUINAZOLIN-4-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
    喹诺酮-4-ONE衍生物及其制备方法及含有它们的药物组合物

    公开(公告)号：US20090149484A1

    公开(公告)日：2009-06-11

    申请号：US12297336

    申请日：2007-04-17

    申请人： Brian Aquila ,  Paul Lyne ,  Timothy Pontz

    发明人： Brian Aquila ,  Paul Lyne ,  Timothy Pontz

    IPC分类号： A61K31/517 ,  C07D239/72 ,  A61P35/00

    CPC分类号： C07D239/90 ,  C07D239/88 ,  C07D401/12

    摘要： The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B-Raf inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.

    摘要翻译： 本发明涉及具有B-Raf抑制活性的式（I）化合物或其药学上可接受的盐，因此可用于其抗癌活性，因此可用于人或动物体的治疗方法。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在制造用于在温血动物如人中产生抗癌作用的药物中的用途。

    QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS
    4.
    发明申请
    QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS 审中-公开

    公开(公告)号：US20090054469A1

    公开(公告)日：2009-02-26

    申请号：US11574036

    申请日：2005-08-28

    申请人： Brian Aquila ,  Paul Lyne ,  Timothy Pontz

    发明人： Brian Aquila ,  Paul Lyne ,  Timothy Pontz

    IPC分类号： A61K31/517 ,  C07D239/72 ,  A61P35/04

    CPC分类号： C07D239/90

    摘要： The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

    Chemical Compounds
    7.
    发明申请
    Chemical Compounds 审中-公开
    化学化合物

    公开(公告)号：US20080146570A1

    公开(公告)日：2008-06-19

    申请号：US11814246

    申请日：2006-01-24

    申请人： Brian Aquila ,  Paul Lyne ,  Timothy Pontz

    发明人： Brian Aquila ,  Paul Lyne ,  Timothy Pontz

    IPC分类号： A61K31/5377 ,  C07D295/00 ,  A61K31/506 ,  A61P35/00 ,  C07D239/00

    CPC分类号： C07D239/42 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12

    摘要： The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof, of the formula (I): which possess B-Raf inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.

    摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐：其具有B-Raf抑制活性，因此可用于其抗癌活性，因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在制造用于在温血动物如人中产生抗癌作用的药物中的用途。