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公开(公告)号：US08741931B2
公开(公告)日：2014-06-03
申请号：US13442244
申请日：2012-04-09
申请人： Juan-Miguel Jimenez , Guy William Bemis , Francois Maltais , Tiansheng Wang , Ronald Marcellus Alphonsus Knegtel , Christopher John Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Paul Mortimore
发明人： Juan-Miguel Jimenez , Guy William Bemis , Francois Maltais , Tiansheng Wang , Ronald Marcellus Alphonsus Knegtel , Christopher John Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Paul Mortimore
IPC分类号： A61K31/444
CPC分类号： C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to compounds having formula: which are useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及具有下式的化合物：其可用作蛋白激酶的抑制剂。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08501446B2
公开(公告)日：2013-08-06
申请号：US13441287
申请日：2012-04-06
申请人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
发明人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
IPC分类号： C12N9/99 , C07D471/02
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D519/00 , C07F7/0805
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US20130023525A1
公开(公告)日：2013-01-24
申请号：US13454510
申请日：2012-04-24
申请人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
发明人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
IPC分类号： A61K31/4184 , C07D401/14 , A61K31/4439 , A61K31/506 , C07D405/14 , A61P31/04 , A61K31/4545 , C07D491/056 , A61K31/4355 , C07D413/14 , A61K31/5377 , A61K31/5513 , C07D403/14 , C07D403/10
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
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公开(公告)号：US08268818B2
公开(公告)日：2012-09-18
申请号：US12438995
申请日：2007-09-04
申请人： Tiansheng Wang , Jeremy Green , Brian Ledford , François Maltais , Andreas P. Termin , Mark Cornebise , Jonathan Parsons , Adam Tanner , James Westcott
发明人： Tiansheng Wang , Jeremy Green , Brian Ledford , François Maltais , Andreas P. Termin , Mark Cornebise , Jonathan Parsons , Adam Tanner , James Westcott
IPC分类号： A61K31/427 , A61K31/454 , A61K31/495 , A61K31/497 , C07D413/14 , C07D405/14 , C07D277/44
CPC分类号： C07D417/04
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20120010222A1
公开(公告)日：2012-01-12
申请号：US13234634
申请日：2011-09-16
申请人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
发明人： Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
IPC分类号： A61K31/506 , A61K31/4184 , A61P31/04 , A61K31/4439
CPC分类号： C07D413/14 , A61K31/4439 , A61K31/506 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to methods of treating, preventing, or lessening the severity of resistant bacterial infections in mammals, utilizing compounds of formula I or formula VII or pharmaceutically salts thereof. The present invention also relates to methods of using compounds of formula I or formula VII in combination with one or more additional antibacterial agents and/or one or more additional therapeutic agents that increase the susceptibility of bacterial organisms to antibiotics.
摘要翻译： 本发明涉及使用式I或式VII化合物或其药学上可接受的方法治疗，预防或减轻哺乳动物中抗性细菌感染的严重性。 本发明还涉及使用式I或式VII化合物与一种或多种另外的抗菌剂和/或一种或多种增加细菌生物体对抗生素敏感性的其它治疗剂的组合的方法。
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公开(公告)号：US07569591B2
公开(公告)日：2009-08-04
申请号：US10901928
申请日：2004-07-29
申请人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven M. Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
发明人： Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven M. Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
IPC分类号： A61K31/4439 , C07D401/00
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
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公开(公告)号：US20090176763A1
公开(公告)日：2009-07-09
申请号：US12273799
申请日：2008-11-19
申请人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
发明人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
IPC分类号： A61K31/55 , C07D401/14 , A61K31/506 , C07D243/08 , A61K31/551 , C07D403/14 , A61K31/496 , C07D471/02 , A61K31/437 , C07D413/14 , A61K31/5377 , A61P37/00 , A61P29/00 , A61P25/00 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D519/00 , C07F7/0805
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US20090124602A1
公开(公告)日：2009-05-14
申请号：US12187909
申请日：2008-08-07
申请人： FRANCOIS MALTAIS , GUY BEMIS , TIANSHENG WANG , JUAN-MIGUEL JIMENEZ , RONALD KNEGTEL , CHRIS DAVIS , DAMIEN FRAYSSE
发明人： FRANCOIS MALTAIS , GUY BEMIS , TIANSHENG WANG , JUAN-MIGUEL JIMENEZ , RONALD KNEGTEL , CHRIS DAVIS , DAMIEN FRAYSSE
IPC分类号： A61K31/551 , C07D213/44 , C07D243/08 , A61K31/496 , A61P25/00 , C07D401/14 , A61K31/444
CPC分类号： C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US20070203142A1
公开(公告)日：2007-08-30
申请号：US11654375
申请日：2007-01-17
申请人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
发明人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
IPC分类号： A61K31/53 , A61K31/513 , A61K31/506 , C07D471/02
CPC分类号： A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D495/10 , C07D519/00 , C12N9/12 , C12Y207/10002
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20060183761A1
公开(公告)日：2006-08-17
申请号：US11346048
申请日：2006-02-01
申请人： Mark Ledeboer , Albert Pierce , Guy Bemis , Luc Farmer , Tiansheng Wang , David Messersmith , John Duffy , Francesco Salituro , Jian Wang
发明人： Mark Ledeboer , Albert Pierce , Guy Bemis , Luc Farmer , Tiansheng Wang , David Messersmith , John Duffy , Francesco Salituro , Jian Wang
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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