公开(公告)号：US09126321B2

公开(公告)日：2015-09-08

申请号：US13456669

申请日：2012-04-26

申请人： Thomas Muller ,  Germar Meiendres

发明人： Thomas Muller ,  Germar Meiendres

IPC分类号： G05D23/00 ,  G05B5/00 ,  H02P1/06 ,  B25F5/00 ,  B25D11/12 ,  B25D16/00

CPC分类号： B25F5/00 ,  B25D11/125 ,  B25D16/00 ,  B25D2216/0015 ,  B25D2216/0023 ,  B25D2216/0038 ,  B25D2250/221

摘要： A machine tool has a tool retainer for retaining a tool, a motor and a drivetrain which couples the motor with the tool retainer for transmitting a torque. A system pushbutton is coupled with a motor control. When the system pushbutton is activated by a user, the motor control controls the motor in such a way that the motor turns in a first sense of rotation for a duration and then in a sense of rotation opposed to the first sense of rotation. The duration is shorter than 100 ms.

摘要翻译： 机床具有用于保持工具的保持器，电动机和传动系，其将电动机与工具保持器联接以传递转矩。 系统按钮与电机控制相结合。 当用户激活系统按钮时，电动机控制器以这样的方式控制电动机，使得电动机转动一段持续时间的第一旋转方向，然后在与第一旋转方向相反的旋转方向上转动。 持续时间短于100 ms。

公开(公告)号：US20140045725A1

公开(公告)日：2014-02-13

申请号：US14004021

申请日：2012-03-15

申请人： Thomas Muller-Spath ,  Lars Aumann ,  Guido Ströhlein ,  Michael Bavand

发明人： Thomas Muller-Spath ,  Lars Aumann ,  Guido Ströhlein ,  Michael Bavand

IPC分类号： C12N15/10

CPC分类号： C12N15/1082 ,  B01D15/166 ,  B01D15/1807 ,  B01D15/1864 ,  C07K1/18 ,  C07K1/22 ,  C07K1/36 ,  C07K2317/31 ,  G01N30/468

摘要： The document pertains to a method for the purification of a ternary mixture of dimeric antibodies of the type AA, AB, BB, characterised in that for the separation of the three components and in particular for the isolation of the multi-specific fraction AB multicolumn counter current solvent gradient purification chromatography with a stationary phase load of more than 1 mg antibody mixture per millilitre stationary phase is used. It furthermore relates to a method for the identification of in particular bispecific antibody systems, which are particularly suitable for the application of such a purification method.

摘要翻译： 该文献涉及纯化AA，AB，BB型二聚体抗体三元混合物的方法，其特征在于分离三种成分，特别是用于分离多特异性级分AB多列计数器 使用当前溶剂梯度纯化色谱法，每毫升固定相具有大于1mg抗体混合物的固定相负载。 它还涉及特别是鉴定特异性双特异性抗体系统的方法，其特别适用于这种纯化方法的应用。

公开(公告)号：US08485658B2

公开(公告)日：2013-07-16

申请号：US13038414

申请日：2011-03-02

申请人： Thomas Muller

发明人： Thomas Muller

IPC分类号： G02C1/00 ,  G02C11/00 ,  G02C5/14

CPC分类号： G02C11/00 ,  G02C5/143

摘要： An eyewear retainer includes a flexible elongated arm and a flexible leg extending downwardly from the posterior end of the arm. Elastic bands on the arm receive and engage a wide range of temple arms of eyewear. The leg extends behind a wearer's ear when the temple arm of the eyewear is engaged by the elastic bands. The retainer is buoyant and may include a bulbous buoyancy cell containing a buoyant object on the lateral side of the leg. Thermal medium compartments are attached to the medial side of the retainer arm and retainer leg. Each thermal medium compartment removably contains a thermal medium, such as a cooling medium or a heating medium. A pressure sensitive skin-contacting adhesive is provided on the outer skin-contacting side (i.e., the medial side) of the thermal medium compartment located on the retainer leg. The retainer leg and arm may be comprised of a material including a thermochromic additive and/or a hydrochromic additive configured to change color when the retainer is submerged in water.

摘要翻译： 眼镜保持器包括柔性细长臂和从臂的后端向下延伸的柔性腿。 手臂上的弹力带接收和接触眼镜的各种寺庙臂。 当眼镜的胳膊臂被弹性带接合时，腿部延伸穿戴者的耳朵后面。 保持器是浮力的并且可以包括在腿的外侧上包含浮力物体的球状浮力单元。 热介质隔室连接到定位臂和保持架腿的内侧。 每个热介质隔室可拆卸地包含热介质，例如冷却介质或加热介质。 压敏皮肤接触的粘合剂设置在位于保持器腿上的热介质室的外皮接触侧（即，内侧）上。 保持器腿和臂可以由包括热变色添加剂和/或配置为当保持器浸没在水中时改变颜色的水铬色添加剂的材料构成。

公开(公告)号：US20110253631A1

公开(公告)日：2011-10-20

申请号：US13141937

申请日：2009-12-16

申请人： Thomas Muller-Spath ,  Lars Aumann

发明人： Thomas Muller-Spath ,  Lars Aumann

IPC分类号： B01D15/18

CPC分类号： B01D15/1821 ,  B01D15/166 ,  B01D15/1864

摘要： A process for continuous or quasi-continuous purification of a multi-component mixture (Fd) by means of at least four individual chromatographic columns through which the mixture is fed by means of at least one solvent (s), is given, wherein the multicomponent mixture (Fd) is to be separated into an integer number n of fractions (Fi), wherein n is at least 5. The columns are grouped into at least six sections ((α1, . . . , αn-3, β1, . . . , βn-3, Y, δ), wherein each section ((α1, . . . , αn-3, βi, . . . , βn-3, γ, δ) comprises at least one column with the proviso that the function of sections can be fulfilled sequentially and can be realized by single columns. There are least two collection, at least two recycling sections (β1, . . . , βn-3), a strongly adsorbing component collection section (γ) and a feed section (δ) The functions of the sections ((α1, . . . , αn-3, βi, . . . , βn-3, γ, δ) are either fulfilled synchronously or sequentially, and columns are run in at least one batch mode position in which the outlets of one or at least two collection section columns ((α1, . . . , (an-3) are used to collect intermediate fractions (F2, . . . , Fn-3) as well as in at least continuous or quasi-continuous mode position, in which the outlets of at least two recycling section columns (β1, . . . , βn-3) are fluidly connected with the corresponding inlets of subsequent downstream recycling sections or, in the absence of a subsequent downstream recycling section, into said feed section. In said batch mode and said continuous or quasi-continuous mode are either realized synchronously or sequentially, wherein after or within a switch time (t*) the columns are moved in their positions in a counter direction to the general direction of flow of the solvent, wherein after or within a switch time (t*) the first column from each collection section ((α1, . . . , αn-3) is moved to the last position of the corresponding recycling section (β1, . . . , βn-3), the first column of the most upstream recycling section (β1) is moved to the first position of the strongly adsorbing component collection section (γ) and the first columns of the further recycling sections (β2, . . . , βn-3) are moved to the last position of the next upstream collection section ((α1, . . . , αn-4), the first column of the strongly adsorbing component collection section (γ) is moved to the last position of the feed section (δ) and the first column of the feed section (δ) is moved to become the last column of the most downstream collection section ((αn-3).

公开(公告)号：US20080227842A1

公开(公告)日：2008-09-18

申请号：US12073888

申请日：2008-03-11

申请人： Bernhard Krautler ,  Thomas Muller

发明人： Bernhard Krautler ,  Thomas Muller

IPC分类号： A61K31/409 ,  C07D403/14 ,  A61K8/49 ,  A61P17/00

CPC分类号： C07D403/14

摘要： The invention relates to a compound of formula (I), or a pharmacologically or cosmetically acceptable salt or derivative thereof, wherein R1 to R5 are selected from the groups R1 representing -alkyl, -vinyl, —CHOH—CH2OH, R2 representing H, —OH, —Oalkyl, —Oacyl, saccharide groups, modified saccharide groups (e.g. malonylated), R3 representing —H, —OH, —Oalkyl, —Oacyl, modified —Oacyl (e.g. malonylated), saccharide groups, modified saccharide groups (e.g. malonylated), R4, R5 representing —COOH, -carbonic esters, for use as drug, antioxidant, food supplement. The invention also relates to a method for producing the compound of formula (I).

摘要翻译： 本发明涉及式（I）化合物或其药理学或化妆品可接受的盐或衍生物，其中R 1至R 5选自基团R 1， 代表烷基， - 乙烯基，-CHOH-CH 2 OH，R 2代表H，-OH， - 烷基， - 酰基，糖类 基团，修饰的糖基（例如丙二酸化），R 3代表-H，-OH， - 烷基， - 酰基，经修饰的酰基（例如丙二酸化），糖基，修饰的糖基（例如丙二酸化） R 4，R 5代表-COOH - 碳酸酯，用作药物，抗氧化剂，食品补充剂。 本发明还涉及制备式（I）化合物的方法。

公开(公告)号：US20080223803A1

公开(公告)日：2008-09-18

申请号：US12076089

申请日：2008-03-13

申请人： Piotr Budny ,  Thomas Muller ,  Matthias Horn ,  Michael Knabe ,  Arnd Meier

发明人： Piotr Budny ,  Thomas Muller ,  Matthias Horn ,  Michael Knabe ,  Arnd Meier

IPC分类号： A47B81/00

CPC分类号： A24C5/358

摘要： A shaft tray for receiving rod-shaped products includes a tray body comprising a rear wall, two substantially parallel and spaced-apart side walls and a bottom wall, arranged to define a receiving chamber for the products. Shaft walls running parallel to the side walls divide the receiving chamber into individual shafts. The shaft walls are mountable separately from the tray body and at least a region of the rear wall of the tray body includes receivers or fasteners to, respectively, receive or fasten the shaft walls to the tray body.

摘要翻译： 用于接收棒状产品的轴托盘包括托盘主体，托盘主体包括后壁，两个基本平行和间隔开的侧壁和底壁，该底壁布置成限定用于产品的接收室。 平行于侧壁延伸的轴壁将接收室分成单独的轴。 轴壁可独立于托盘主体安装，并且托盘主体的后壁的至少一个区域包括分别将轴壁接纳或固定到托盘主体的接收器或紧固件。

公开(公告)号：US20080190074A1

公开(公告)日：2008-08-14

申请号：US12068637

申请日：2008-02-08

申请人： Piotr Budny ,  Thomas Muller ,  Matthias Horn ,  Michael Knabe ,  Arnd Meier

发明人： Piotr Budny ,  Thomas Muller ,  Matthias Horn ,  Michael Knabe ,  Arnd Meier

IPC分类号： B65B19/00 ,  A24C5/352 ,  B23Q7/00 ,  B65B35/00 ,  B65B5/00

CPC分类号： A24C5/354

摘要： An apparatus is provided for filling an empty shaft tray with rod-shaped products. The shaft tray has shaft walls which form a plurality of shafts. The apparatus includes a filling hopper having a receiving region for a mass flow composed of the products, and a storage region for products comprising a front wall, a rear wall, side walls and a bottom wall. The storage region includes partitions that form a plurality of shafts adjacent to each other, wherein the partitions substantially extend over a full height of the storage region, and wherein the rear wall of the storage region includes openings for passage of the shaft walls of the shaft tray. A delivery element delivers the empty shaft tray into the receiving region of the filling hopper to be filled with the products. A removal element removes a filled shaft tray from the filling hopper.

摘要翻译： 提供一种用于用棒状产品填充空轴托盘的装置。 轴托盘具有形成多个轴的轴壁。 该装置包括：填充料斗，其具有用于由产品组成的质量流的接收区域，以及用于包括前壁，后壁，侧壁和底壁的产品的存储区域。 存储区域包括形成彼此相邻的多个轴的隔板，其中分隔件基本上延伸超过存储区域的整个高度，并且其中存储区域的后壁包括用于轴的轴壁通过的开口 托盘。 输送元件将空轴托盘输送到填充料斗的接收区域中以填充产品。 去除元件从填充料斗中取出填充的轴托盘。

公开(公告)号：US20070295839A1

公开(公告)日：2007-12-27

申请号：US11562638

申请日：2006-11-22

申请人： Thomas Muller ,  Christoph Wolf

发明人： Thomas Muller ,  Christoph Wolf

IPC分类号： B05B1/14

CPC分类号： D04H18/04 ,  D04H1/492

摘要： Nozzle beam on device for generating liquid jets for jet interweaving of the fibers of a fiber path, comprising an upper part that extends over the operational width of the fiber path, and a lower part that is attached to it in liquid-sealed fashion, wherein a) a pressure chamber is arrayed in the upper part over its length, to which liquid under pressure is fed, and b) a pressure-distributing chamber is provided parallel to chamber (a), which is connected with chamber (a) via liquid flow-through boreholes situated in an intermediate partition, and c) on the lower part, a nozzle strip having boreholes for the nozzle chamber is supported in liquid-sealed fashion, and d) (b) on the area that lies opposite the liquid flow-through boreholds runs out into a slot that terminates at the boreholes of the nozzle strip, and e) in (b) between the liquid flow-through boreholes and the slot, a baffle is situated over the length of the slot, which over its length and over its cross section is situated in (a) so as to allow free flow around it, and the baffle is not screwed to the nozzle beam, but rather inserted into it and can be removed from it, the baffle being held by spacers in a centric or eccentric position.

摘要翻译： 用于产生用于喷射交织纤维路径的纤维的液体喷嘴的喷嘴梁，包括在纤维路径的操作宽度上延伸的上部，以液体密封的方式附接到其上的下部， a）压力室排列在其长度上部的上部，压力供给液体; b）平行于室（a）设置的压力分配室，其通过液体与室（a）连接 位于中间隔板中的流通钻孔，以及c）在下部，具有用于喷嘴室的钻孔的喷嘴条以液体密封的方式支撑，以及d）（b）在与液体流动相对的区域上 通过钻孔延伸到终止于喷嘴条的钻孔处的槽中，以及e）在液体流通孔和槽之间的（b）中，挡板位于槽的长度上方， 长度和横截面是情况 （a）中以允许其周围的自由流动，并且挡板未拧到喷嘴梁上，而是插入其中并且可以从其中移除，挡板由间隔件保持在中心或偏心位置。

公开(公告)号：US20070263708A1

公开(公告)日：2007-11-15

申请号：US11760065

申请日：2007-06-08

申请人： Thomas Muller ,  Jurgen Schnitzler

发明人： Thomas Muller ,  Jurgen Schnitzler

IPC分类号： H04B1/38

CPC分类号： H04L1/1809 ,  H04L1/1854

摘要： A Bluetooth radio transceiver, for receiving isochronous data, comprising: receiving means for receiving data; determining means for determining whether the received data has been correctly or incorrectly received; validation means for determining whether the received data is current; and transmission means, for transmitting, in response to received data, a positive acknowledgement of reception when the received data has been correctly received, a negative acknowledgement when the received data has been incorrectly received and the received data is current and a positive acknowledgement when the received data has been incorrectly received and the received data is not current is described. The determination of whether data is current occurs at the receiver as opposed to the transmitter.

摘要翻译： 一种用于接收等时数据的蓝牙无线电收发器，包括：用于接收数据的接收装置; 确定装置，用于确定所接收的数据是否已被正确地或不正确地被接收; 用于确定所接收的数据是否是当前的确认装置; 以及发送装置，用于响应于所接收的数据，在接收到的数据被正确地接收时发送肯定的接收确认，当所接收的数据被不正确地接收到并且所接收的数据是当前的时候的肯定确认， 接收到的数据被错误地接收并且接收到的数据不是当前的。 在接收机上确定数据是否为电流，而不是发射机。

公开(公告)号：US07280524B2

公开(公告)日：2007-10-09

申请号：US10169980

申请日：2001-01-12

申请人： Thomas Muller ,  Jurgen Schnitzler

发明人： Thomas Muller ,  Jurgen Schnitzler

IPC分类号： G06F11/00

CPC分类号： H04L1/1809 ,  H04L1/1854

摘要： A Bluetooth radio transceiver, for receiving isochronous data, comprising: receiving means for receiving data; determining mean for determining whether the received data has been correctly or incorrectly received; validation means for determining whether the received data is current; and transmission means, for transmitting, in response to received data, a positive acknowledgement of reception when the received data has been correctly received, a negative acknowledgement when the received data has been incorrectly received and the received data is current and a positive acknowledgement when the received data has been incorrectly received and the received data is not current. The determination of whether data is current occurs at the receiver as opposed to the transmitter.

摘要翻译： 一种用于接收等时数据的蓝牙无线电收发器，包括：用于接收数据的接收装置; 确定用于确定所接收的数据是否被正确地或不正确地接收的平均值; 用于确定所接收的数据是否是当前的确认装置; 以及发送装置，用于响应于所接收的数据，在接收到的数据被正确地接收时发送肯定的接收确认，当所接收的数据被不正确地接收到并且所接收的数据是当前的时候的肯定确认， 接收到的数据已被错误地接收，并且接收的数据不是当前的。 在接收机上确定数据是否为电流，而不是发射机。