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    Generation of patient-specific differentiated cell types by epigenetic induction
    1.
    发明授权
    Generation of patient-specific differentiated cell types by epigenetic induction 有权
    通过表观遗传诱导产生患者特异性分化细胞类型

    公开(公告)号：US08865463B2

    公开(公告)日：2014-10-21

    申请号：US12998381

    申请日：2009-10-26

    申请人： Thiru Venkat Gopal

    发明人： Thiru Venkat Gopal

    IPC分类号： C12N5/00 ,  C12N5/16

    CPC分类号： C12N5/0619 ,  C12N5/0691 ,  C12N5/16 ,  C12N5/166 ,  C12N2500/46 ,  C12N2501/06 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/59 ,  C12N2501/73 ,  C12N2501/998 ,  C12N2506/00 ,  C12N2506/30

    摘要： Disclosure of a mammalian cytoplasmic donor cell line. Disclosure of a patient specific cell line. Disclosure of a method to obtain a mammalian cytoplasmic donor cell line by fusing a differentiated mammalian cell and a functionally enucleated mammalian embryonic cell line. Disclosure of a method to obtain a patient specific cell line of a cell type similar to a mammalian cytoplasmic donor cell line by functionally enucleating the mammalian cytoplasmic donor cell line and fusing the functionally enucleated mammalian cytoplasmic donor cell line with a differentiated cell obtained from the patient. A method of treatment administering the patient-specific cell line to the patient.

    摘要翻译： 公开哺乳动物细胞质供体细胞系。 患者特异性细胞系的披露。 披露通过融合分化的哺乳动物细胞和功能去核的哺乳动物胚胎细胞系获得哺乳动物细胞质供体细胞系的方法。 披露通过功能性去核哺乳动物细胞质供体细胞系获得类似于哺乳动物细胞质供体细胞系的细胞类型的患者特异性细胞系的方法，并将功能性去核的哺乳动物细胞质供体细胞系与获自患者的分化细胞融合 。 一种治疗患者特异性细胞系给予患者的方法。

    Generation of Patient-Specific Differentiated Cell Types by Epigenetic Induction
    3.
    发明申请
    Generation of Patient-Specific Differentiated Cell Types by Epigenetic Induction 审中-公开
    通过表观遗传诱导产生患者特异性分化细胞类型

    公开(公告)号：US20150210985A1

    公开(公告)日：2015-07-30

    申请号：US14684252

    申请日：2015-04-10

    申请人： Thiru Venkat Gopal

    发明人： Thiru Venkat Gopal

    IPC分类号： C12N5/26

    CPC分类号： C12N5/0619 ,  C12N5/0691 ,  C12N5/16 ,  C12N5/166 ,  C12N2500/46 ,  C12N2501/06 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/59 ,  C12N2501/73 ,  C12N2501/998 ,  C12N2506/00 ,  C12N2506/30

    摘要： Disclosure of a mammalian cytoplasmic donor cell line. Disclosure of a patient specific cell line. Methods to obtain a mammalian cytoplasmic donor cell line by fusing a differentiated mammalian cell and a functionally enucleated mammalian embryonic cell line. Methods to obtain a mammalian cytoplasmic donor cell line by fusing a differentiated mammalian cell and a functionally enucleated human cancer cell. Methods to obtain a patient specific cell line of a cell type similar to a mammalian cytoplasmic donor cell line by functionally enucleating the mammalian cytoplasmic donor cell line and fusing the functionally enucleated mammalian cytoplasmic donor cell line with a differentiated cell obtained from the patient. A method of treatment of a human patient by administering the patient-specific cell line to the patient.

    摘要翻译： 公开哺乳动物细胞质供体细胞系。 患者特异性细胞系的披露。 通过融合分化的哺乳动物细胞和功能去核的哺乳动物胚胎细胞系获得哺乳动物细胞质供体细胞系的方法。 通过融合分化的哺乳动物细胞和功能去核的人类癌细胞获得哺乳动物细胞质供体细胞系的方法。 通过功能性去除哺乳动物细胞质供体细胞系并将功能性去核的哺乳动物细胞质供体细胞系与从患者获得的分化细胞融合来获得类似于哺乳动物细胞质供体细胞系的细胞类型的患者特异性细胞系的方法。 一种通过向患者施用患者特异性细胞系来治疗人类患者的方法。

    Epigenetic induction of human patient-specific self-propagating dopaminergic neuron cell
    4.
    发明授权
    Epigenetic induction of human patient-specific self-propagating dopaminergic neuron cell 有权
    人类特异性自体传播多巴胺能神经元细胞的表观遗传诱导

    公开(公告)号：US09382516B2

    公开(公告)日：2016-07-05

    申请号：US14484439

    申请日：2014-09-12

    申请人： Thiru Venkat Gopal

    发明人： Thiru Venkat Gopal

    IPC分类号： C12N5/00 ,  C12N5/26 ,  C12N5/16 ,  C12N5/071

    CPC分类号： C12N5/0619 ,  C12N5/0691 ,  C12N5/16 ,  C12N5/166 ,  C12N2500/46 ,  C12N2501/06 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/59 ,  C12N2501/73 ,  C12N2501/998 ,  C12N2506/00 ,  C12N2506/30

    摘要： Disclosure of a mammalian cytoplasmic donor cell line. Disclosure of a patient specific cell line. Disclosure of a method to obtain a mammalian cytoplasmic donor cell line by fusing a differentiated mammalian cell and a functionally enucleated mammalian embryonic cell line. Disclosure of a method to obtain a patient specific cell line of a cell type similar to a mammalian cytoplasmic donor cell line by functionally enucleating the mammalian cytoplasmic donor cell line and fusing the functionally enucleated mammalian cytoplasmic donor cell line with a differentiated cell obtained from the patient. A method of treatment administering the patient-specific cell line to the patient.

    摘要翻译： 公开哺乳动物细胞质供体细胞系。 患者特异性细胞系的披露。 披露通过融合分化的哺乳动物细胞和功能去核的哺乳动物胚胎细胞系获得哺乳动物细胞质供体细胞系的方法。 披露通过功能性去核哺乳动物细胞质供体细胞系获得类似于哺乳动物细胞质供体细胞系的细胞类型的患者特异性细胞系的方法，并将功能性去核的哺乳动物细胞质供体细胞系与获自患者的分化细胞融合 。 一种治疗患者特异性细胞系给予患者的方法。

    Generation of Patient-Specific Differentiated Cell Types by Epigenetic Induction
    5.
    发明申请
    Generation of Patient-Specific Differentiated Cell Types by Epigenetic Induction 审中-公开
    通过表观遗传诱导产生患者特异性分化细胞类型

    公开(公告)号：US20150004689A1

    公开(公告)日：2015-01-01

    申请号：US14484439

    申请日：2014-09-12

    申请人： Thiru Venkat Gopal

    发明人： Thiru Venkat Gopal

    IPC分类号： C12N5/0793

    CPC分类号： C12N5/0619 ,  C12N5/0691 ,  C12N5/16 ,  C12N5/166 ,  C12N2500/46 ,  C12N2501/06 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/59 ,  C12N2501/73 ,  C12N2501/998 ,  C12N2506/00 ,  C12N2506/30

    摘要： Disclosure of a mammalian cytoplasmic donor cell line. Disclosure of a patient specific cell line. Disclosure of a method to obtain a mammalian cytoplasmic donor cell line by fusing a differentiated mammalian cell and a functionally enucleated mammalian embryonic cell line. Disclosure of a method to obtain a patient specific cell line of a cell type similar to a mammalian cytoplasmic donor cell line by functionally enucleating the mammalian cytoplasmic donor cell line and fusing the functionally enucleated mammalian cytoplasmic donor cell line with a differentiated cell obtained from the patient. A method of treatment administering the patient-specific cell line to the patient.

    摘要翻译： 公开哺乳动物细胞质供体细胞系。 患者特异性细胞系的披露。 披露通过融合分化的哺乳动物细胞和功能去核的哺乳动物胚胎细胞系获得哺乳动物细胞质供体细胞系的方法。 披露通过功能性去核哺乳动物细胞质供体细胞系获得类似于哺乳动物细胞质供体细胞系的细胞类型的患者特异性细胞系的方法，并将功能性去核的哺乳动物细胞质供体细胞系与获自患者的分化细胞融合 。 一种治疗患者特异性细胞系给予患者的方法。

    Generation of patient-specific differentiated cell types by epigenetic induction
    6.
    发明授权
    Generation of patient-specific differentiated cell types by epigenetic induction 有权

    公开(公告)号：US10100280B2

    公开(公告)日：2018-10-16

    申请号：US15186379

    申请日：2016-06-17

    申请人： Thiru Venkat Gopal

    发明人： Thiru Venkat Gopal

    IPC分类号： C12N5/16 ,  C12N5/0793 ,  C12N5/26 ,  C12N5/071

    摘要： Disclosure of a mammalian cytoplasmic donor cell line. Disclosure of a patient specific cell line. Methods to obtain a mammalian cytoplasmic donor cell line by fusing a differentiated mammalian cell and a functionally enucleated mammalian embryonic cell line. Methods to obtain a mammalian cytoplasmic donor cell line by fusing a differentiated mammalian cell and a functionally enucleated human cancer cell. Methods to obtain a patient specific cell line of a cell type similar to a mammalian cytoplasmic donor cell line by functionally enucleating the mammalian cytoplasmic donor cell line and fusing the functionally enucleated mammalian cytoplasmic donor cell line with a differentiated cell obtained from the patient. A method of treatment of a human patient by administering the patient-specific cell line to the patient.