公开(公告)号：US20250050047A1

公开(公告)日：2025-02-13

申请号：US18719658

申请日：2022-12-12

Applicant: The United States Government as represented by the Department of Veterans Affairs ,  The Board of Trustees of the University of Illinois

Inventor： Israel Rubinstein ,  Andrea Benedetti ,  Alexander Twaddle ,  Grace Dyer ,  Kimberlee Wilkens ,  Lara Nammari

IPC: A61M16/06 ,  A61M16/00

Abstract: A gas flow control device uses the curvature of nasal cannula or other tubes conveying the gas to control an actuator movable between two different configurations to permit or prevent gas flow. Curvature of the nasal cannula is measured by a sensor whose electrical resistance changes in response to the curvature of the sensor. The sensor is mounted on the cannula. Signals from the sensor are transmitted to a controller, which moves the actuator when the curvature exceeds or falls below a threshold value as measured by the change in electrical resistance of the sensor. The device finds use in oxygen therapy, where oxygen flow to a patient is cut off when the sensor indicates non-compliant behavior by the patient, indicating release of oxygen into the environment and causing a potential fire hazard.

公开(公告)号：US20250043343A1

公开(公告)日：2025-02-06

申请号：US17440746

申请日：2020-03-16

Applicant: The Board of Trustees of the University of Illinois

Inventor： Rashid BASHIR ,  Anurup GANGULI

IPC: C12Q1/6874 ,  B01J19/00

Abstract: Provided herein are methods of making a spatially-barcoded microarray, the method comprising the steps of: providing distinguishable mini-barcoded beads, wherein the distinguishable mini-barcoded beads comprise a plurality of distinct bead populations, with each bead member of a distinct population having an identical mini-barcode sequence; simultaneously delivering the plurality of distinguishable barcoded beads to a plurality of wells of a microarray, wherein a single bead is provided to each well; imaging the plurality of wells to identify the population type of each bead in each of the plurality of wells and thereby identify the mini-barcode in each well; removing the mini-barcodes from the beads and connecting the mini-barcode or a polymerase product of the mini-barcode to a surface of the well in which the bead is located; and removing the beads from the wells.

公开(公告)号：US20250032212A1

公开(公告)日：2025-01-30

申请号：US18833569

申请日：2023-01-12

Applicant: The Board of Trustees of the University of Illinois

Inventor： Michael Oelze ,  Jenna Cairo

IPC: A61B90/90 ,  A61B8/08 ,  A61B90/00

Abstract: A radiological clip for locating marked tissue within a diagnostic ultrasound image may transmit an ultrasound identification (USID) signal within a bandwidth of ultrasound imaging pulses. A same ultrasound imaging array that receives the ultrasound imaging pulses may also receive the USID signal. An ultrasound imaging apparatus may generate an ultrasound image of the tissue that indicates a location and ID of the radiological clip based on the ultrasound imaging pulses and the USID signal received from the radiological clip within the imaging field. The radiological clip may generate an activation signal in response to receiving an ultrasound imaging pulse, generate an identification signal responsive to the activation signal, and transmit a USID signal based on the identification signal. The USID signal may include encoded signals corresponding to different bits within a multiple-bit identification tag to uniquely identify the radiological clip within a diagnostic image.

公开(公告)号：US12205338B2

公开(公告)日：2025-01-21

申请号：US17518026

申请日：2021-11-03

Applicant: The Board of Trustees of the University of Illinois (Urbana, IL) ,  SAMSUNG ELECTRONICS CO., LTD.

Inventor： Jihye Kim ,  Raymond Alexander Yeh ,  Alexander Gerhard Schwing ,  Yuan-Ting Hu

IPC: G06V10/25 ,  G06T7/11 ,  G06V10/24

Abstract: A segmentation method and segmentation apparatus are provided, where the segmentation method includes receiving image frames comprising a current frame and an adjacent frame to the current frame, determining a feature map to aggregate the image frames based on temporal information between the current frame and the adjacent frame, extracting a feature of a region of interest (ROI) corresponding to instances included in the current frame from the feature map, predicting a class of an object corresponding to the ROI based on the feature of the ROI, and segmenting the instances by correcting an amodal mask predicted corresponding to the class of the object based on the feature of the ROI.

公开(公告)号：US20250017915A1

公开(公告)日：2025-01-16

申请号：US18710037

申请日：2022-11-15

Applicant: The Board of Trustees of the University of Illinois ,  The United States Government as Represented by The Department of Veterans Affairs

Inventor： Gregory R. Thatcher ,  Ajay Rana ,  Rui Xiong ,  Daniel Principe ,  Yangfeng Li

IPC: A61K31/444 ,  A61K39/395 ,  A61P35/00

Abstract: In accordance with the purpose(s) of the present disclosure, described herein are methods for treating cancer associated with a Ras mutation in a subject in need of treatment comprising administering to the subject an effective amount of a compound of formula I as described herein or a pharmaceutically acceptable salt thereof. The compounds described herein have improved efficacy compared to the benchmark BET inhibitor JQ-1 and comparable efficacy to high dose JQ-1 with respect to the treatment of PDAC. In one aspect, the compounds are administered in combination with an effective amount of an immune checkpoint inhibitor such as, for example, PD-1/PD-L 1 inhibitor, a CTLA-4 inhibitor, or a combination thereof.

公开(公告)号：US12195753B2

公开(公告)日：2025-01-14

申请号：US17941835

申请日：2022-09-09

Applicant: The Board of Trustees of the University of Illinois ,  Cambridge Enterprise Limited

Inventor： Aleksei Aksimentiev ,  Ulrich F. Keyser

IPC: C12N5/00 ,  A61K9/51 ,  A61K31/711 ,  A61K31/713 ,  C12N15/11

Abstract: The present invention provides compositions and methods for transferring phospholipids and other molecules between the leaflets of a cell membrane. The compositions comprise at least one nucleic acid or compound having a hydrophilic region, where the composition is able to form a nanostructure that forms a toroidal pore in a lipid membrane. The nucleic acid or hydrophilic region-containing compound further contains an attached molecule capable of inserting the nanostructure into the lipid membrane. The invention also provides methods for scrambling lipids and other molecules in a cell membrane, which can be used to alter the function of a selected cell or to facilitate the death of the cell. The scrambling activity of synthetic scramblases described herein outperforms previously known enzymatically active DNA nanostructures and naturally occurring scramblases, in some cases by several orders of magnitude.

公开(公告)号：US20250009776A1

公开(公告)日：2025-01-09

申请号：US18891739

申请日：2024-09-20

Applicant: The Board of Trustees of the University of Illinois ,  cystetic Medicines, Inc.

Inventor： Martin D. Burke ,  Agnieszka Lewandowska ,  Corinne Soutar ,  Jeffry G. Weers ,  Thomas Tarara ,  Danforth P. Miller

IPC: A61K31/7048 ,  A61K9/00 ,  A61K9/127 ,  A61K9/16

Abstract: Disclosed are pharmaceutical compositions, comprising: (i) amphotericin B or a pharmaceutically acceptable salt or hydrate thereof; (ii) cholesterol; (iii) phospholipids, comprising hydrogenated soy phosphatidylcholine and distearoylphosphatidylglycerol; and (iv) calcium chloride (CaCl2)). Also disclosed are methods of using the pharmaceutical compositions for treating a disease or disorder (e.g., cystic fibrosis), increasing the pH of airway surface liquid, increasing bicarbonate secretion into airway surface liquid, and increasing a subject's forced expiratory volume in one second.

公开(公告)号：US12186508B2

公开(公告)日：2025-01-07

申请号：US17720514

申请日：2022-04-14

Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS ,  BIOVENTURES, LLC

Inventor： Maxwell Bean ,  Morten Jensen ,  Barry Uretsky ,  Kaitlyn Elmer

IPC: A61M25/10 ,  A61F2/95 ,  A61F2/954 ,  A61F2/958 ,  B29L31/00 ,  B33Y80/00

Abstract: Patient specific medical balloons, assemblies, and systems for forming the same, and devices and methods for treating patients in need of a percutaneous coronary intervention (PCI) are disclosed. The assembly for forming the medical balloon comprises a form for receiving a parison where the form is configured to prepare a patient specific medical balloon matched in geometry to a blood vessel or a lesion for a patient in need of a PCI.

公开(公告)号：US20240424163A1

公开(公告)日：2024-12-26

申请号：US18686954

申请日：2022-09-02

Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

Inventor： Ali R. DJALILIAN ,  Ghasem YAZDANPANAH

IPC: A61L24/00

Abstract: Disclosed is a thermoresponsive, in situ curable hydrogel composition composed of decellularized corneal extracellular matrix functionalized with an acrylate in admixture with a photo-initiator, said hydrogel composition being of use in the treatment of an ocular surface wound.

公开(公告)号：US12167911B2

公开(公告)日：2024-12-17

申请号：US17147654

申请日：2021-01-13

Applicant: The Board of Trustees of the University of Illinois ,  OSF Healthcare System

Inventor： Seung Yun Song ,  Elizabeth T. Hsiao-Wecksler ,  Christopher M. Zallek

IPC: A61B5/11 ,  A61B5/00 ,  A61B5/107

Abstract: The disclosure is directed to a method and apparatus for measuring and assessing limb movement properties. The method includes conducting a test protocol with a position, velocity, and resistance meter (PVRM); and obtaining raw data from the PVRM and transmitting the raw data from the PVRM to an electronic device. The method includes processing the raw data to obtain processed data; and obtaining a set of parameters based on the processed data. The method includes obtaining a classification result according to a classifying algorithm based on the set of parameters; and assessing, recording, and displaying a limb movement property according to the classification result.