公开(公告)号：US20050272645A1

公开(公告)日：2005-12-08

申请号：US10982145

申请日：2004-11-05

Applicant: Robert Lehrer ,  Alan Waring ,  Alexander Cole ,  Teresa Hong

Inventor： Robert Lehrer ,  Alan Waring ,  Alexander Cole ,  Teresa Hong

IPC: A61K38/00 ,  C07K7/64 ,  A61K38/12

CPC classification number: C07K7/08 ,  A61K38/00 ,  C07K7/06 ,  C07K7/64

Abstract: Retrocyclin peptides are small antimicrobial agents with potent activity against bacteria and viruses. The peptides are nonhemolytic, and exhibit minimal in vitro cytotoxicity. A pharmaceutical composition comprising retrocyclin as an active agent is administered therapeutically to a patient suffering from a bacterial and/or viral infection, or to an individual facing exposure to a bacterial and/or viral infection, especially one caused by the HIV-1 retrovirus or other sexually-transmitted pathogens.

Abstract translation: 逆转录肽是针对细菌和病毒的有效活性的小抗微生物剂。 肽是非溶血性的，并且表现出最小的体外细胞毒性。 包含逆转录酶作为活性剂的药物组合物治疗性地给予患有细菌和/或病毒感染的患者或面临暴露于细菌和/或病毒感染的个体，特别是由HIV-1逆转录病毒或 其他性传播病原体。

公开(公告)号：US20080085286A1

公开(公告)日：2008-04-10

申请号：US11754252

申请日：2007-05-25

Applicant: Markus Kalkum ,  Diana Diaz-Arevalo ,  James Ito ,  Joseph Lyons ,  Teresa Hong

Inventor： Markus Kalkum ,  Diana Diaz-Arevalo ,  James Ito ,  Joseph Lyons ,  Teresa Hong

IPC: A61K39/00 ,  A61P43/00

CPC classification number: A61K39/0002

Abstract: The present invention relates to compositions and methods in preventing and/or treating diseases caused by Aspergillus. In particular, the present invention is directed to Aspergillus vaccine preparations and methods of making and using thereof.

Abstract translation: 本发明涉及预防和/或治疗由曲霉菌引起的疾病的组合物和方法。 特别地，本发明涉及曲霉疫苗制剂及其制备和使用方法。