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    Preparation process of nitroguanidine derivatives
    3.
    发明授权
    Preparation process of nitroguanidine derivatives 失效
    硝基胍衍生物的制备方法

    公开(公告)号：US6118007A

    公开(公告)日：2000-09-12

    申请号：US46588

    申请日：1998-03-24

    Applicant: Koichi Ebihara ,  Tatsuo Kaiho ,  Michihiko Miyamoto ,  Daisuke Ura

    Inventor： Koichi Ebihara ,  Tatsuo Kaiho ,  Michihiko Miyamoto ,  Daisuke Ura

    IPC: C07D277/28 ,  C07D277/32 ,  C07D407/06 ,  C07D417/06 ,  C07D263/30 ,  C07D333/22

    CPC classification number: C07D277/32 ,  C07D407/06 ,  C07D417/06

    Abstract: A process, as a substitute for hydrolysis, for preparing a nitroguanidine derivative represented by the following formula (2): ##STR1## wherein A represents a substituted or unsubstituted aromatic or non-aromatic hydrocarbon ring, a substituted or unsubstituted aromatic or non-aromatic heterocycle, a hydrogen atom or a substituted or unsubstituted alkyl, alkenyl or alkynyl group; and R.sub.2 represents a hydrogen atom, a substituted or unsubstituted C.sub.1-6 alkyl, alkenyl or alkynyl group, which comprises reacting a compound represented by the following formula (1): ##STR2## wherein R.sub.1 represents a substituted or unsubstituted, linear or cyclic C.sub.1-10 alkyl group and A and R.sub.2 have the same meanings as defined above, with ammonia, a primary amine or a secondary amine, or a salt thereof.

    Abstract translation: 用于制备由下式（2）表示的硝基胍衍生物的方法作为水解的替代方法：其中A表示取代或未取代的芳族或非芳族烃环，取代或未取代的芳族或非芳族杂环， 氢原子或取代或未取代的烷基，烯基或炔基; R 2表示氢原子，取代或未取代的C 1-6烷基，烯基或炔基，其包括使下式（1）表示的化合物：其中R 1表示取代或未取代的直链或环状C 1-10烷基 基团和A和R 2具有与上述相同的含义，与氨，伯胺或仲胺或其盐。

    Isoquinoline derivatives
    4.
    发明授权
    Isoquinoline derivatives 失效
    异喹啉衍生物

    公开(公告)号：US4782154A

    公开(公告)日：1988-11-01

    申请号：US75828

    申请日：1987-07-17

    Applicant: Tatsuo Kaiho ,  Seitaro Kajiya ,  Kengo Otsuka ,  Masahiko Maruyama ,  Makoto Hirayama

    Inventor： Tatsuo Kaiho ,  Seitaro Kajiya ,  Kengo Otsuka ,  Masahiko Maruyama ,  Makoto Hirayama

    IPC: A61K31/47 ,  A61P9/00 ,  A61P9/04 ,  C07D401/04 ,  C07D217/16

    CPC classification number: C07D401/04

    Abstract: The isoquinoline derivatives represented by the following general formula (I) are useful as cardiotonics having high cardiotonic activity and low toxicity: ##STR1## where R.sub.1 represents a lower C.sub.1 -C.sub.4 alkyl group or cyclopropyl group,R.sub.2 represents formyl group, lower C.sub.1 -C.sub.4 alkanoyl group and benzoyl group, lower C.sub.1 -C.sub.4 alkyl group, lower C.sub.1 -C.sub.4 alkenyl group, lower C.sub.1 -C.sub.4 hydroxy substituted alkyl group, C.sub.1 -C.sub.4 perfluoroalkyl group andR.sub.3 represents 4-pyridyl group or 2-pyridyl group respectively,and the therapeutically acceptable salts thereof are also useful as cardiotonics.

    Abstract translation: 由以下通式（I）表示的异喹啉衍生物可用作具有高强度活性和低毒性的强心剂：其中R 1表示低级C 1 -C 4烷基或环丙基，R 2表示甲酰基，低级 C1-C4烷酰基和苯甲酰基，低级C1-C4烷基，低级C1-C4烯基，低级C1-C4羟基取代烷基，C1-C4全氟烷基，R3分别代表4-吡啶基或2-吡啶基 ，其治疗上可接受的盐也可用作强心剂。

    Process for preparing 4-acetyl isoquinolinone compounds
    6.
    发明授权
    Process for preparing 4-acetyl isoquinolinone compounds 失效
    制备4-乙酰基异喹啉酮化合物的方法

    公开(公告)号：US4814458A

    公开(公告)日：1989-03-21

    申请号：US10304

    申请日：1987-02-02

    Applicant: Nobuyuki Fukazawa ,  Tatsuo Kaiho ,  Hiroyuki Yamashita

    Inventor： Nobuyuki Fukazawa ,  Tatsuo Kaiho ,  Hiroyuki Yamashita

    IPC: C07D401/04

    CPC classification number: C07D401/04

    Abstract: This invention relates to a novel process for preparing 4-acetyl-1-methyl-7-pyridyl-5,6,7,8-tetrahydro-3(2H)-isoquinolinone characterized by condensing 2-acetyl-4-pyridyl cyclohexanone with acetoacetamide. This compound is useful as pharmaceuticals, particularly cardiotonics.

    Abstract translation: 本发明涉及一种制备4-乙酰基-1-甲基-7-吡啶基-5,6,7,8-四氢-3（2H） - 异喹啉酮的新方法，其特征在于将2-乙酰基-4-吡啶基环己酮与乙酰乙酰胺 。 该化合物可用作药物，特别是强心剂。

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