公开(公告)号：US20250034551A1

公开(公告)日：2025-01-30

申请号：US18707093

申请日：2022-11-03

Applicant: THINK BIOSCIENCE, INC. ,  THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Nolan O'CONNOR ,  Andrew MARKLEY ,  Hannah EDSTROM ,  Jerome Michael FOX ,  Tommaso Antonio FODERARO ,  Ankur Kulshreshtha SARKAR ,  Matthew TRAYLOR ,  Levi Daniel KRAMER ,  Gregory DONOVAN

IPC: C12N15/10 ,  C12N9/12 ,  C12N9/88 ,  C12Q1/6853 ,  C12Q1/6869 ,  G01N33/50

Abstract: Provided are high-throughput screens for biologically active modulators of a target enzyme that mimic or recreate natural processes of diversification and selection. In some embodiments, the platform comprises one or more expression systems including without limitation (i) a two-hybrid system that, when expressed in a cell, links survival of the cell to the modulation of a therapeutic target, and (ii) a metabolic system that enables the biosynthesis of structurally varied modulators of the therapeutic agent.