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1.发明公开公开(公告)号：US20230270668A1
公开(公告)日：2023-08-31
申请号：US18045745
申请日：2022-10-11
申请人： AUGMENTA BIOWORKS, INC. , TFF PHARMACEUTICALS, INC. , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： Christopher J. EMIG , Steven J. HENRY , Adela Anne VITUG , Dale J. CHRISTENSEN , Zhengrong CUI , Haiyue XU , Robert O. WILLIAMS, III
CPC分类号： A61K9/0075 , C07K16/1018 , A61P31/14
摘要： The invention generally encompasses a human-derived monoclonal antibody compositions and methods comprising a dry powder formulation for neutralizing SARS-CoV-2 and known variants thereof in a patient, comprising administering to the patient a dry powder formulation comprising the human-derived monoclonal antibody. The invention further encompasses compositions and methods comprising a dry powder formulation for treating or preventing COVID-19 and/or at least one symptom associated with COVID-19 in a patient, comprising administering to the patient a dry powder formulation comprising the human-derived monoclonal antib.
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公开(公告)号：US20230117531A1
公开(公告)日：2023-04-20
申请号：US17906529
申请日：2021-03-18
发明人： Glenn MATTES , Aaron FLETCHER , Carlo CASULO
IPC分类号： A61K9/00 , A61K31/352 , A61K31/05 , A61K9/19
摘要： The disclosure relates to dry powder compositions of (a) a plant-based cannabidiol (pCBD) composition, or (b) a plant-based tetrahydrocannabinol composition (pTHC); or (c) a synthetic cannabidiol composition (sCBD), or (d) a synthetic tetrahydrocannabinol composition (sTHC), or (e) a plant-based cannabidiol (pCBD) composition in combination with a a plant-based tetrahydrocannabinol composition (pTHC), or (f) a synthetic cannabidiol composition (sCBD) in combination with a synthetic tetrahydrocannabinol composition (sTHC) and their delivery to the airway of a subject using a dry powder inhaler.
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公开(公告)号：US20230263816A1
公开(公告)日：2023-08-24
申请号：US18005522
申请日：2021-07-16
发明人： Robert O. WILLIAMS, III , Chaeho MOON , Sawittree SAHAKIJPIJARN , Dale CHRISTENSEN , Glenn MATTES , John J. KOLENG
CPC分类号： A61K31/706 , A61K9/0075 , A61K47/183 , A61K47/26 , A61K47/40 , A61K45/06
摘要： The present disclosure provides pharmaceutical compositions of remdesivir that may be administered by inhalation. These compositions may allow the achievement of a therapeutically effective dose of remdesivir directly to the lungs. These compositions may be used to treat one or more diseases or disorders such as a viral infection like an infection of a coronavirus.
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4.发明公开公开(公告)号：US20230190735A1
公开(公告)日：2023-06-22
申请号：US18082963
申请日：2022-12-16
发明人： Dale J. Christensen , John Koleng
IPC分类号： A61K31/496 , A61K9/00 , A61P31/10
CPC分类号： A61K31/496 , A61K9/0073 , A61P31/10
摘要： The invention generally encompasses compositions and methods including inhalable voriconazole or a pharmaceutically acceptable salt thereof manufactured in amorphous form using thin film freezing. In various embodiments, the invention includes a dry powder voriconazole formulation that can be inhaled, for example, using a dry powder inhaler, and is well tolerated as a daily regimen for treating or preventing fungal infections. The compositions and methods of the invention avoid or reduce the systemic circulation of voriconazole and accordingly overcome the adverse events associated circulating voriconazole.
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公开(公告)号：US20220313611A1
公开(公告)日：2022-10-06
申请号：US17693062
申请日：2022-03-11
IPC分类号： A61K9/14 , A61P37/02 , A61P31/10 , A61P33/10 , A61K9/16 , A61K9/50 , A61K31/436 , A61K31/506 , A61K31/167
摘要： In some aspects, the present disclosure provides methods of preparing pharmaceutical compositions using an suspension based thin film freezing method to obtain inhalable compositions. These compositions may have a higher homogeneity compared to compositions prepared using conventional methods. These compositions may be used to treat or prevent one or more diseases or disorders.
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6.发明公开公开(公告)号：US20230288116A1
公开(公告)日：2023-09-14
申请号：US18120514
申请日：2023-03-13
CPC分类号： F25C1/14 , F25B9/002 , F25C2301/00
摘要： The invention encompasses methods for the large-scale (preferably under cGMP or cGLP standards) preparation of micron-sized or submicron-sized particles including pharmaceutical or biologic active agents. The systems and methods include a cryogenic cooling system including a novel shroud that enhances the cooling effects thereby reducing product loss and increasing product yields.
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公开(公告)号：US20230112800A1
公开(公告)日：2023-04-13
申请号：US17823635
申请日：2022-08-31
IPC分类号： A61K9/28 , A61K31/167 , A61K9/20
摘要： The present disclosure provides pharmaceutical compositions of niclosamide that may be administered orally. These compositions may allow the achievement of a therapeutically effective dose of niclosamide while preventing crystallization in the stomach which reduces bioavailability. These compositions may be used to treat one or more diseases or disorders such as a viral infection or cancer.
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公开(公告)号：US20220362222A1
公开(公告)日：2022-11-17
申请号：US17742945
申请日：2022-05-12
IPC分类号： A61K31/436 , A61K9/00 , A61K9/14 , A61K47/26
摘要： The present disclosure provides methods of using and pharmaceutical compositions of tacrolimus that may be administered by inhalation once a day. These methods and compositions may be used to generate a blood plasma concentration of tacrolimus in a therapeutically effective range using only a single dose daily. Administration once daily may result in few adverse events and reduced side effects while increasing patient compliance.
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公开(公告)号：US20220339227A1
公开(公告)日：2022-10-27
申请号：US17642295
申请日：2020-09-18
摘要： The disclosure relates to dry powder compositions of (a) a plant-based cannabidiol (pCBD) composition, or (b) a plant-based tetrahydrocannabinol composition (pTHC); or (c) a synthetic cannabidiol composition (sCBD), or (d) a synthetic tetrahydrocannabinol composition (sTHC), or (e) a plant-based cannabidiol (pCBD) composition in combination with a plant-based tetrahydrocannabinol composition (pTHC), or (f) a synthetic cannabidiol composition (sCBD) in combination with a synthetic tetrahydrocannabinol composition (sTHC) and their delivery to the airway of a subject using a dry powder inhaler.
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