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1.发明授权公开(公告)号：US07662864B2
公开(公告)日：2010-02-16
申请号：US10861881
申请日：2004-06-04
CPC分类号： A61K9/0024 , A61K47/34 , A61L27/34 , A61L27/54 , A61L2300/21 , A61L2300/41 , A61L2300/416 , A61L2300/604
摘要： Anhydride polymers that release active or activatable agent(s) have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The polymers are suitable for use in compositions, formulations, coatings, devices, and the like that benefit from the controlled release of an agent(s) over a period of time. The polymers are prepared by a process involving various alternative and sequential steps that allow the design a priori of products with specific characteristics. The polymers are suitable as delivery systems, either by themselves, as compositions, formulations or devices.
摘要翻译： 释放活性或可活化剂的酐聚合物具有预先选择的性质，例如分子量，柔韧性，硬度，粘合性和其它有价值的性质。 聚合物适用于在一段时间内受益于试剂的受控释放的组合物，制剂，涂料，装置等中。 聚合物通过涉及各种替代和顺序步骤的方法制备，其允许先验地设计具有特定特征的产品。 聚合物本身适合作为递送系统，作为组合物，制剂或装置。
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公开(公告)号：US09108070B2
公开(公告)日：2015-08-18
申请号：US13467623
申请日：2012-05-09
CPC分类号： A61K31/616 , A01N39/02 , A61K8/37 , A61K8/69 , A61K8/8164 , A61K47/542 , A61Q17/005
摘要： Conjugates comprising at least two active agents linked by a diglycolic acid or polyglycol diacid linker are disclosed. The invention also concerns oligomers and polymers of these conjugates and their use in therapeutic and industrial applications for localized, immediate or fast release delivery of an active agent, such as an anti-microbial, anti-infective, or antiseptic agent.
摘要翻译： 公开了包含至少两种通过二甘醇二酸或聚二醇二酸连接体连接的活性剂的缀合物。 本发明还涉及这些缀合物的低聚物和聚合物及其在治疗和工业应用中用于活性剂如抗微生物剂，抗感染剂或防腐剂的局部，即时或快速释放递送的用途。
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3.发明申请HIGH MOLECULAR WEIGHT POLYMERS, DEVICES AND METHOD FOR MAKING AND USING SAME 有权高分子量聚合物，制备和使用它们的装置和方法公开(公告)号：US20100152410A1
公开(公告)日：2010-06-17
申请号：US12500438
申请日：2009-07-09
申请人： Anthony East , Alan Letton , Suseela Kanamathareddy , Bryant J. Pudil , Stephen Goodrich , Michael B. Hicks , Yun Choe
发明人： Anthony East , Alan Letton , Suseela Kanamathareddy , Bryant J. Pudil , Stephen Goodrich , Michael B. Hicks , Yun Choe
IPC分类号： C08G63/682
CPC分类号： A61K9/0024 , A61K47/34 , A61L27/34 , A61L27/54 , A61L2300/21 , A61L2300/41 , A61L2300/416 , A61L2300/604
摘要： Anhydride polymers that release active or activatable agent(s) have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The polymers are suitable for use in compositions, formulations, coatings, devices, and the like that benefit from the controlled release of an agent(s) over a period of time. The polymers are prepared by a process involving various alternative and sequential steps that allow the design a priori of products with specific characteristics. The polymers are suitable as delivery systems, either by themselves, as compositions, formulations or devices.
摘要翻译： 释放活性或可活化剂的酐聚合物具有预先选择的性质，例如分子量，柔韧性，硬度，粘合性和其它有价值的性质。 聚合物适用于在一段时间内受益于试剂的受控释放的组合物，制剂，涂料，装置等中。 聚合物通过涉及各种替代和顺序步骤的方法制备，其允许先验地设计具有特定特征的产品。 聚合物本身适合作为递送系统，作为组合物，制剂或装置。
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公开(公告)号：US20050131199A1
公开(公告)日：2005-06-16
申请号：US10848560
申请日：2004-05-18
申请人： Kathryn Uhrich , Robert Schmeltzer , Theodore Anastasiou , Bryant Pudil , Richard Wood , Suseela Kanamathareddy
发明人： Kathryn Uhrich , Robert Schmeltzer , Theodore Anastasiou , Bryant Pudil , Richard Wood , Suseela Kanamathareddy
IPC分类号： A61K47/48 , C07C67/14 , C07C69/353 , C07C69/86 , C07C231/12 , C07C233/54 , C08G63/00 , C08G63/06 , C08G67/04
摘要： The present invention provides a method for forming compounds of Formula HO—C(═O)R1—X—R2—X—R1—C(═O)—O—H wherein compound (I) can be polymerized to provide a polymer that contains therapeutically active compounds. In the compounds of the invention, each R1 is group that will provide the therapeutically active compound upon hydrolysis of the polymer; each X is independently an ester linkage or an amide linkage; and R2 is a linking group.
摘要翻译： 本发明提供了一种形成式<β的化合物的方法，该方法包括在线式描述=“在线式”中的末端=“铅”→HO-C（ - ）R 1 - XR 2 -XR 1 -C（-O）-OH＆lt;β-in-line-formula description =“In-line Formulas”end =“tail”？>其中 化合物（I）可以聚合以提供含有治疗活性化合物的聚合物。 在本发明的化合物中，每个R 1是在聚合物水解时提供治疗活性化合物的基团; 每个X独立地是酯键或酰胺键; R 2是连接基团。
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公开(公告)号：US20130071458A1
公开(公告)日：2013-03-21
申请号：US13467623
申请日：2012-05-09
IPC分类号： A01N37/14 , A61K31/621 , A61K9/00 , A01P3/00 , A01P1/00 , A01N25/00 , C07C69/736 , A61P17/00
CPC分类号： A61K31/616 , A01N39/02 , A61K8/37 , A61K8/69 , A61K8/8164 , A61K47/542 , A61Q17/005
摘要： Conjugates comprising at least two active agents linked by a diglycolic acid or polyglycol diacid linker are disclosed. The invention also concerns oligomers and polymers of these conjugates and their use in therapeutic and industrial applications for localized, immediate or fast release delivery of an active agent, such as an anti-microbial, anti-infective, or antiseptic agent.
摘要翻译： 公开了包含至少两种通过二甘醇二酸或聚二醇二酸连接体连接的活性剂的缀合物。 本发明还涉及这些缀合物的低聚物和聚合物及其在治疗和工业应用中用于活性剂如抗微生物剂，抗感染剂或防腐剂的局部，即时或快速释放递送的用途。
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公开(公告)号：US20100310498A1
公开(公告)日：2010-12-09
申请号：US12813776
申请日：2010-06-11
IPC分类号： A61K31/787 , C07C69/78 , A01N37/40 , A61K31/616 , A61P39/06 , A61P31/04 , A61P29/00 , A61P31/00 , A61P17/00 , C08G63/66 , C08F226/06 , A61K31/765 , A01P1/00
CPC分类号： A61K31/616 , A01N39/02 , A61K8/37 , A61K8/69 , A61K8/8164 , A61K47/542 , A61Q17/005
摘要： Conjugates comprising at least two active agents linked by a diglycolic acid or polyglycol diacid linker are disclosed. The invention also concerns oligomers and polymers of these conjugates and their use in therapeutic and industrial applications for localized, immediate or fast release delivery of an active agent, such as an anti-microbial, anti-infective, or antiseptic agent.
摘要翻译： 公开了包含至少两种通过二甘醇二酸或聚二醇二酸连接体连接的活性剂的缀合物。 本发明还涉及这些缀合物的低聚物和聚合物及其在治疗和工业应用中用于活性剂如抗微生物剂，抗感染剂或防腐剂的局部，即时或快速释放递送的用途。
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7.发明授权公开(公告)号：US08232322B2
公开(公告)日：2012-07-31
申请号：US12500438
申请日：2009-07-09
申请人： Anthony East , Alan Letton , Suseela Kanamathareddy , Bryant J. Pudil , Stephen Goodrich , Michael B. Hicks , Yun Choe
发明人： Anthony East , Alan Letton , Suseela Kanamathareddy , Bryant J. Pudil , Stephen Goodrich , Michael B. Hicks , Yun Choe
CPC分类号： A61K9/0024 , A61K47/34 , A61L27/34 , A61L27/54 , A61L2300/21 , A61L2300/41 , A61L2300/416 , A61L2300/604
摘要： Anhydride polymers that release active or activatable agent(s) have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The polymers are suitable for use in compositions, formulations, coatings, devices, and the like that benefit from the controlled release of an agent(s) over a period of time. The polymers are prepared by a process involving various alternative and sequential steps that allow the design a priori of products with specific characteristics. The polymers are suitable as delivery systems, either by themselves, as compositions, formulations or devices.
摘要翻译： 释放活性或可活化剂的酐聚合物具有预先选择的性质，例如分子量，柔韧性，硬度，粘合性和其它有价值的性质。 聚合物适用于在一段时间内受益于试剂的受控释放的组合物，制剂，涂料，装置等中。 聚合物通过涉及各种替代和顺序步骤的方法制备，其允许先验地设计具有特定特征的产品。 聚合物本身适合作为递送系统，作为组合物，制剂或装置。
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8.发明申请公开(公告)号：US20050048121A1
公开(公告)日：2005-03-03
申请号：US10861881
申请日：2004-06-04
申请人： Anthony East , Alan Letton , Suseela Kanamathareddy , Bryant Pudil , Stephen Goodrich , Michael Hicks , Karen Giroux , Yun Choe
发明人： Anthony East , Alan Letton , Suseela Kanamathareddy , Bryant Pudil , Stephen Goodrich , Michael Hicks , Karen Giroux , Yun Choe
CPC分类号： A61K9/0024 , A61K47/34 , A61L27/34 , A61L27/54 , A61L2300/21 , A61L2300/41 , A61L2300/416 , A61L2300/604
摘要： Anhydride polymers that release active or activatable agent(s) have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The polymers are suitable for use in compositions, formulations, coatings, devices, and the like that benefit from the controlled release of an agent(s) over a period of time. The polymers are prepared by a process involving various alternative and sequential steps that allow the design a priori of products with specific characteristics. The polymers are suitable as delivery systems, either by themselves, as compositions, formulations or devices.
摘要翻译： 释放活性或可活化剂的酐聚合物具有预先选择的性质，例如分子量，柔韧性，硬度，粘合性和其它有价值的性质。 聚合物适用于在一段时间内受益于试剂的受控释放的组合物，制剂，涂料，装置等中。 聚合物通过涉及各种替代和顺序步骤的方法制备，其允许先验地设计具有特定特征的产品。 聚合物本身适合作为递送系统，作为组合物，制剂或装置。
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