公开(公告)号：US20120178793A1

公开(公告)日：2012-07-12

申请号：US13424282

申请日：2012-03-19

Applicant: Raphael J. Mannino ,  Susan Gould-Fogerite

Inventor： Raphael J. Mannino ,  Susan Gould-Fogerite

IPC: A61K31/713 ,  A61P31/04 ,  A61P31/18 ,  A61P31/10 ,  A61P35/00 ,  A61P31/12

CPC classification number: A61K9/1274 ,  A61K31/7088 ,  A61K47/6919 ,  C07H21/02 ,  C07H21/04

Abstract: The present invention is directed to cochleate composition that include a nucleotide. The nucleotide may generally be bound via a linker to a component of the cochleate, or to a lipophilic tail. Additionally or alternatively, the nucleotide may he associated with a transfection agent. The present invention also includes methods for making and using, the compositions provided herein.

Abstract translation: 本发明涉及包含核苷酸的耳蜗组合物。 核苷酸通常可以通过接头连接到耳蜗组分或亲脂性尾部。 另外或替代地，核苷酸可以与转染剂相关联。 本发明还包括制备和使用本文提供的组合物的方法。

公开(公告)号：US20080009457A1

公开(公告)日：2008-01-10

申请号：US11653093

申请日：2007-01-11

Applicant: Susan Gould-Fogerite ,  Raphael Mannino ,  Patrick Ahl ,  Gaofeng Shang ,  Zi Chen ,  Sara Krause-Elsmore

Inventor： Susan Gould-Fogerite ,  Raphael Mannino ,  Patrick Ahl ,  Gaofeng Shang ,  Zi Chen ,  Sara Krause-Elsmore

IPC: A61K31/7052 ,  A61P17/00 ,  A61P19/00 ,  A61P25/00 ,  A61P3/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  A61P7/00 ,  A61P9/00 ,  C12N5/00

CPC classification number: A61K9/127 ,  A61K9/1274 ,  A61K31/7048 ,  A61K31/7088 ,  A61K38/00 ,  A61K47/6919 ,  C07H21/02 ,  C07H21/04 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/3233 ,  C12N2310/53 ,  C12N2320/32 ,  C12Y102/01012

Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.

Abstract translation: 本文公开了新的siRNA-耳蜗和吗啉代 - 耳蜗组合物。 还公开了制备和使用siRNA-耳蜗和吗啉代 - 耳蜗组合物的方法。

公开(公告)号：US20070237814A1

公开(公告)日：2007-10-11

申请号：US11653434

申请日：2007-01-11

Applicant: Raphael Mannino ,  Susan Gould-Fogerite ,  Sara Krause-Elsmore ,  David Delmarre ,  Ruying Lu

Inventor： Raphael Mannino ,  Susan Gould-Fogerite ,  Sara Krause-Elsmore ,  David Delmarre ,  Ruying Lu

IPC: A61K9/127

CPC classification number: A61K9/1277 ,  A61K9/1274 ,  A61K31/00 ,  A61K31/135 ,  A61K31/167 ,  A61K31/395 ,  A61K31/60 ,  A61K31/7036 ,  A61K31/7048 ,  A61K38/12 ,  A61K38/14 ,  G01N33/5091

Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.

Abstract translation: 公开了用于制备耳蜗和耳蜗组合物的新方法，其包括在溶剂存在下将货物部分引入脂质体。 还公开了包括聚集抑制剂和任选的货物部分的耳蜗和耳蜗组合物。 另外，公开了包括质子化货物部分，二价金属阳离子和负电荷脂质的无水耳蜗。 还公开了使用本发明的耳蜗组合物的方法，包括施用方法。

公开(公告)号：US20060029656A1

公开(公告)日：2006-02-09

申请号：US11051562

申请日：2005-02-03

Applicant: Francis O'Donnell ,  Raphael Mannino ,  Susan Gould-Fogerite

Inventor： Francis O'Donnell ,  Raphael Mannino ,  Susan Gould-Fogerite

IPC: A61K38/46 ,  A61K38/47 ,  A61K9/127

CPC classification number: A61K9/0019 ,  A61K9/1274 ,  A61K38/47 ,  A61K47/6949 ,  B82Y5/00

Abstract: Disclosed are cochleates and cochleate compositions that associated with an replacement enzyme component and/or a plasmid component that encodes a replacement enzyme. Also disclosed are methods of making and using the compositions of the invention, including methods of administration. Use of the invention provides safe, effective and efficient delivery of replacement enzymes and/or plasmids encoding the same in a variety of dosage forms.

Abstract translation: 公开了与替代酶组分和/或编码替代酶的质粒组分相关的耳蜗和耳蜗组合物。 还公开了制备和使用本发明组合物的方法，包括给药方法。 本发明的使用提供以多种剂型形式安全，有效和有效地递送替代酶和/或编码其的质粒。

公开(公告)号：US20050008686A1

公开(公告)日：2005-01-13

申请号：US10759381

申请日：2004-01-15

Applicant: Raphael Mannino ,  Sara Krause-Elsmore ,  Susan Gould-Fogerite ,  David Delmarre ,  Feng Tan

Inventor： Raphael Mannino ,  Sara Krause-Elsmore ,  Susan Gould-Fogerite ,  David Delmarre ,  Feng Tan

IPC: A21D2/00 ,  A21D2/36 ,  A23L1/00 ,  A23L1/275 ,  A23L1/30 ,  A61K9/127

CPC classification number: A61K9/1274 ,  A21D2/00 ,  A21D2/36 ,  A23L5/44 ,  A23L33/115 ,  A23P10/35 ,  A23V2002/00 ,  A23V2250/712 ,  A23V2250/211 ,  A23V2250/1852 ,  A23V2200/224

Abstract: The present invention provides novel fragile nutrient cochleates that generally include one or more encochleated fragile nutrients, e.g., beta carotene, and methods for making the same. Also provided are methods for the use and administration of the fragile nutrient cochleates of the invention.

Abstract translation: 本发明提供了通常包括一种或多种易受伤害的脆弱营养物质，例如β-胡萝卜素的新型脆性营养成分，及其制备方法。 本发明还提供了使用和施用本发明的脆性营养耳蜗的方法。

公开(公告)号：US08642073B2

公开(公告)日：2014-02-04

申请号：US11653434

申请日：2007-01-11

Applicant: Raphael J. Mannino ,  Susan Gould-Fogerite ,  Sara L. Krause-Elsmore ,  David Delmarre ,  Ruying Lu

Inventor： Raphael J. Mannino ,  Susan Gould-Fogerite ,  Sara L. Krause-Elsmore ,  David Delmarre ,  Ruying Lu

IPC: A61K9/127

CPC classification number: A61K9/1277 ,  A61K9/1274 ,  A61K31/00 ,  A61K31/135 ,  A61K31/167 ,  A61K31/395 ,  A61K31/60 ,  A61K31/7036 ,  A61K31/7048 ,  A61K38/12 ,  A61K38/14 ,  G01N33/5091

Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.

Abstract translation: 公开了用于制备耳蜗和耳蜗组合物的新方法，其包括在溶剂存在下将货物部分引入脂质体。 还公开了包括聚集抑制剂和任选的货物部分的耳蜗和耳蜗组合物。 另外，公开了包括质子化货物部分，二价金属阳离子和负电荷脂质的无水耳蜗。 还公开了使用本发明的耳蜗组合物的方法，包括施用方法。

公开(公告)号：US20050129661A1

公开(公告)日：2005-06-16

申请号：US11042598

申请日：2005-01-24

Applicant: David Margolis ,  Susan Gould-Fogerite ,  Raphael Mannino

Inventor： David Margolis ,  Susan Gould-Fogerite ,  Raphael Mannino

IPC: A61K9/127 ,  A61K48/00 ,  C07K14/015 ,  C12N15/864 ,  C12N15/88 ,  C12N15/90 ,  C12N15/861

CPC classification number: C12N15/86 ,  A61K9/127 ,  A61K9/1274 ,  A61K48/00 ,  A61K48/0025 ,  C07K14/005 ,  C12N15/88 ,  C12N15/907 ,  C12N2750/14122 ,  C12N2750/14143

Abstract: An integrative DNA vector and one or more viral proteins having affinity for DNA are packaged in cochleate precipitates. The integrative DNA vector contains one or more therapeutic nucleotide sequences that are preferably positioned between DNA substrates for the proteins. Upon contact with a lipid bilayer of a target cell, the cochleate vector structure delivers one or more of the therapeutic nucleotide sequences and one or more proteins to the interior of the target cell. Upon entry into the cell, the proteins facilitate the integration of the therapeutic nucleotide sequence into the genome of the host cell.

Abstract translation: 将整合的DNA载体和对DNA具有亲和力的一种或多种病毒蛋白质包装在耳蜗沉淀物中。 整合DNA载体含有一个或多个优选位于蛋白质的DNA底物之间的治疗性核苷酸序列。 在与靶细胞的脂质双层接触时，耳蜗载体结构将一种或多种治疗性核苷酸序列和一种或多种蛋白质递送至靶细胞的内部。 进入细胞后，蛋白促进了治疗性核苷酸序列整合到宿主细胞的基因组中。

公开(公告)号：US20050013855A1

公开(公告)日：2005-01-20

申请号：US10822235

申请日：2004-04-09

Applicant: Susan Gould-Fogerite ,  Raphael Mannino ,  Patrick Ahl ,  Gaofeng Shang ,  Zi Chen ,  Sara Krause-Elsmore

Inventor： Susan Gould-Fogerite ,  Raphael Mannino ,  Patrick Ahl ,  Gaofeng Shang ,  Zi Chen ,  Sara Krause-Elsmore

IPC: A61K9/00 ,  A61K9/127 ,  A61K31/7048 ,  A61K38/00 ,  A61K47/48 ,  C12N15/11 ,  C12N15/113 ,  A61K48/00 ,  C07H21/02

CPC classification number: A61K9/127 ,  A61K9/1274 ,  A61K31/7048 ,  A61K31/7088 ,  A61K38/00 ,  A61K47/6919 ,  C07H21/02 ,  C07H21/04 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/3233 ,  C12N2310/53 ,  C12N2320/32 ,  C12Y102/01012

Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.

Abstract translation: 本文公开了新的siRNA-耳蜗和吗啉代 - 耳蜗组合物。 还公开了制备和使用siRNA-耳蜗和吗啉代 - 耳蜗组合物的方法。

公开(公告)号：US20130224284A1

公开(公告)日：2013-08-29

申请号：US13854487

申请日：2013-04-01

Applicant: Raphael J. Mannino ,  Sara L. Krause-Elsmore ,  Susan Gould-Fogerite ,  David Delmarre ,  Ruying Lu

Inventor： Raphael J. Mannino ,  Sara L. Krause-Elsmore ,  Susan Gould-Fogerite ,  David Delmarre ,  Ruying Lu

IPC: A61K9/127 ,  A23L1/00

CPC classification number: A61K9/127 ,  A23L33/10 ,  A23L33/175 ,  A23P10/35 ,  A61K9/107 ,  A61K9/1274 ,  A61K9/1617

Abstract: The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for later addition of cargo moieties are also contemplated.

Abstract translation: 本发明提供地质输送载体及制造和给药方法。 公开了一种载体，其包括围绕疏水结构域设置的脂质单层，其可以是乳液或其它混合物的一部分，或进一步置于脂质层中。 还公开了一种包括设置在疏水区域周围的脂质层的载体。 该载体可以并入各种药用，食品制剂和个人护理产品中以输送或稳定货物部分。 还考虑了用于稍后添加货物部件的包装运送车辆。

公开(公告)号：US20060019870A1

公开(公告)日：2006-01-26

申请号：US11047373

申请日：2005-01-28

Applicant: Francis O'Donnell ,  Susan Gould-Fogerite ,  Raphael Mannino

Inventor： Francis O'Donnell ,  Susan Gould-Fogerite ,  Raphael Mannino

IPC: A61K38/17 ,  A61K31/685

CPC classification number: A61K9/1274 ,  A61K31/685 ,  A61K38/1709

Abstract: Disclosed herein are cochleates and cochleate compositions associated with an apoprotein component and/or a plasmid component that encodes an apoprotein. Also disclosed are methods of making and using the compositions of the invention, including methods of administration. Use of the invention provides safe, effective and efficient delivery of apoproteins and/or plasmids encoding the same in a variety of dosage forms.

Abstract translation: 本文公开了与编码脱辅基蛋白的脱辅基蛋白组分和/或质粒组分相关的耳蜗和耳蜗组合物。 还公开了制备和使用本发明组合物的方法，包括给药方法。 使用本发明提供以多种剂型形式安全，有效和有效地递送编码其的蛋白质和/或质粒。