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1.发明公开公开(公告)号：US20240123058A1
公开(公告)日：2024-04-18
申请号：US18276700
申请日：2022-01-29
Applicant: XIAMEN UNIVERSITY , SUN YAT-SEN UNIVERSITY CANCER CENTER (SUN YAT-SEN UNIVERSITY CANCER CENTER HOSPITAL, SUN YAT-SEN , SUN YAT-SEN UNIVERSITY
Inventor： Yixin CHEN , Xiao ZHANG , Junping HONG , Miao XU , Qian WU , Ling ZHONG , Ningshao XIA
IPC: A61K39/245 , A61P35/00 , C07K16/08 , C12N7/00
CPC classification number: A61K39/245 , A61P35/00 , C07K16/085 , C12N7/00 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2319/30
Abstract: Provided are an epitope peptide (or a variant thereof) that can be used for preventing or treating an EBV infection, a recombinant protein containing the epitope peptide (or variant thereof) and a carrier protein, and the use of the epitope peptide (or variant thereof) and the recombinant protein. Further provided are an antibody against the epitope peptide, and the use thereof in the detection, prevention and/or treatment of an EBV infection and/or diseases caused by the infection.
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公开(公告)号：US20180018816A1
公开(公告)日：2018-01-18
申请号：US15623363
申请日：2017-06-14
Applicant: THE FIRST AFFILIATED HOSPITAL OF SUN YAT-SEN UNIVERSITY , SCHOOL OF DATA AND COMPUTER SCIENCE OF SUN YAT-SEN UNIVERSITY , NATIONAL SUPERCOMPUTER CENTRE IN GUANGZHOU OF SUN YAT-SEN UNIVERSITY
Inventor： Liwei Yan , Shuang Zhu , Xiaolin Liu , Jian Qi , Qingtang Zhu , Yao Lu , Yongze Guo , Sha Yu , Yutong Lu , Xi Zhang , Yunfei Du , Tao Lin
CPC classification number: G06T17/00 , G01N1/30 , G01N2001/302 , G01N2001/305 , G06T7/10 , G06T15/04 , G06T2207/10081 , G06T2207/30004 , G06T2210/41 , G06T2211/40 , G06T2215/16
Abstract: The present invention relates to fields of clinical application of nerve defect repair and the medical three-dimensional (3D) printing technology, and provides an integrated visualization method for three-dimensional (3D) reconstruction of internal structure of human peripheral nerves. The method comprises the following steps: obtaining human peripheral nerves, preparing nerve specimens ex vivo by staining with an iodine preparation in combination with a freeze-drying method; scanning the pretreated peripheral nerves using Micro CT to acquire lossless two-dimensional images, and performing binarization processing to the two-dimensional images, then conducting image segmentation based on textural features to acquire images of nerve fascicles; finally, reconstructing the segmented images into a visualization model by using a supercomputer.
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3.发明公开公开(公告)号：US20230364190A1
公开(公告)日：2023-11-16
申请号：US18195381
申请日：2023-05-10
Applicant: Sun Yat-sen University , Sun Yat-sen University Cancer Center (Affiliated Cancer Hospital of Sun Yat-sen University, Cancer
Inventor： Tong XIANG , Jianchuan XIA , Yulong HAN , Yao ZHU
CPC classification number: A61K38/1875 , A61P35/00 , A61K35/17 , C07K16/2896
Abstract: A method of using BMP9 in combination with an NK cell and a PD-L1 antibody in preparing a medicament for treating liver cancer is provided. Specifically, BMP9 is loaded on a drug carrier microbubble to give a BMP9-carrying microbubble (MB-BMP9), and administered in combination with a natural killer cell (NK cell) and a programmed death-ligand 1 (PD-L1) antibody for treating hepatocellular carcinoma (HCC). The present invention can significantly enhance the efficacy of existing programmed death-ligand 1 (PD-L1) antibody therapies and significantly inhibit the growth of HCC cell graft tumors with significant efficacy.
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公开(公告)号：US10147228B2
公开(公告)日：2018-12-04
申请号：US15623363
申请日：2017-06-14
Applicant: THE FIRST AFFILIATED HOSPITAL OF SUN YAT-SEN UNIVERSITY , SCHOOL OF DATA AND COMPUTER SCIENCE OF SUN YAT-SEN UNIVERSITY , NATIONAL SUPERCOMPUTER CENTRE IN GUANGZHOU OF SUN YAT-SEN UNIVERSITY
Inventor： Liwei Yan , Shuang Zhu , Xiaolin Liu , Jian Qi , Qingtang Zhu , Yao Lu , Yongze Guo , Sha Yu , Yutong Lu , Xi Zhang , Yunfei Du , Tao Lin
Abstract: The present invention relates to fields of clinical application of nerve defect repair and the medical three-dimensional (3D) printing technology, and provides an integrated visualization method for three-dimensional (3D) reconstruction of internal structure of human peripheral nerves. The method comprises the following steps: obtaining human peripheral nerves, preparing nerve specimens ex vivo by staining with an iodine preparation in combination with a freeze-drying method; scanning the pretreated peripheral nerves using Micro CT to acquire lossless two-dimensional images, and performing binarization processing to the two-dimensional images, then conducting image segmentation based on textural features to acquire images of nerve fascicles; finally, reconstructing the segmented images into a visualization model by using a supercomputer.
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公开(公告)号：US20250067177A1
公开(公告)日：2025-02-27
申请号：US18929709
申请日：2024-10-29
Applicant: Shenzhen Campus of Sun Yat-sen university , Sun Yat-sen university , SOUTHERN MARINE SCIENCE AND ENGINEERING GUANGDONG LABORATORY(ZHU HAI)
Inventor： LINCHONG HUANG , XUMIN HUANG , YU LIANG , CHENYANG ZHAO , CUNGANG LIN
Abstract: The present invention discloses a control apparatus and method for buoyancy adjustment of shield tunnel segments, wherein the inner end wall of anchor rod accommodating cavity is provided with a first slurry channel extending forward to the outer peripheral wall of anchor rod, the countersunk bolt is provided with a second slurry channel passing through the front and rear end faces of the countersunk bolt, and a locking structure is disposed in the accommodating cavity to lock the countersunk bolt in the accommodating cavity and connect the first slurry channel and second slurry channel. The entire construction process which can be carried out during the construction or operation period greatly reduces construction costs and space.
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Patent Agency Ranking
公开(公告)号：US20240058441A1
公开(公告)日：2024-02-22
申请号：US17766450
申请日：2021-05-18
Inventor： Musheng Zeng , Jie Yang , Guokai Feng , Qiaoli Wang
IPC: A61K39/395 , A61K38/46 , C07K16/40 , A61K31/5377 , A61P35/00 , C12N9/64
CPC classification number: A61K39/3955 , A61K38/46 , C07K16/40 , A61K31/5377 , A61P35/00 , C12N9/6424 , C12Y304/21 , C07K2319/33 , C07K2317/569
Abstract: Disclosed are a fusion protein, and a preparation method and use thereof, which belong to the field of biomedicine technologies. The fusion protein comprises a polypeptide specifically bound to a KRas protein, a specific tumor-cell-penetrating peptide and a lysosome recognition peptide. The fusion protein with tumor targeting, penetrability and specific protein degradation is designed and constructed direct to an undruggable protein for the first time, thus providing a new idea for development of an anti-cancer targeted drug. Different from the prior art in which one molecule can only target one target protein, the fusion protein can simultaneously induce degradation of wild-type and mutant-type KRas proteins. Meanwhile, the fusion protein can improve the sensitivity of the KRas mutant-type tumor to the tumor-targeted drug by inducing degradation of KRas, thus expanding an application range of existing anti-cancer targeted drugs and having important significance in tumor clinic treatment.
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公开(公告)号：US20230194554A1
公开(公告)日：2023-06-22
申请号：US18073905
申请日：2022-12-02
Applicant: Sun Yat-sen University Cancer Center (The Affiliated Cancer Hospital of Sun Yat-sen University, The
IPC: G01N33/68
CPC classification number: G01N33/6893
Abstract: A medical diagnosis screens a biomarker for lung cancer detection by utilizing serum metabonomics. The medical diagnosis includes a biomarker for differential diagnosis between patients with lung cancer and healthy people, and between patients with lung cancer and patients with benign pulmonary nodules, and a biomarker for differential diagnosis between patients with lung cancer and healthy people, and between patients with lung cancer and patients with benign pulmonary nodules according to gender differences between a man and a woman. The biomarker is of great significance especially in the differential diagnosis of whether a patient with nodules in the lung has lung cancer.
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公开(公告)号：US11203541B2
公开(公告)日：2021-12-21
申请号：US16996179
申请日：2020-08-18
Applicant: SUN YAT-SEN UNIVERSITY , SHENZHEN LISAI INDUSTRY DEVELOPMENT CO., LTD. , Shenzhen Research Institute of Sun Yat-sen University
Inventor： Hui Lu , Xingxing Diao , Hequ Peng , Shijun Liu , Qing Zhao , Liao Meng , Naiqiao Song
IPC: C02F3/30 , C02F3/34 , C02F103/06 , C02F101/16
Abstract: An advanced nitrogen removal method using partial nitrification-denitrification coupled two-stage autotrophic denitrification. Sewage is introduced into a first pool for partial nitrification-denitrification treatment, and then introduced into a first regulating reservoir. Dissolved oxygen content in the first pool is kept at 0.4-0.6 mg/L. Water is discharged when a molar ratio of nitrite nitrogen to ammonia nitrogen in the first regulating reservoir is 1.0-1.3:1. Effluent in the regulating reservoir is introduced into a second pool for anaerobic ammonia oxidation treatment, and then introduced into a second regulating reservoir. In the second pool, pH is 7.0-7.4, a temperature is 22-28° C. Effluent in the second regulating reservoir and sulfides are introduced into a third pool for denitrification treatment. Water is discharged. In the third pool, pH is 7.5-8.0, a temperature is 28-32° C., a mass ratio of sulfur to nitrogen is 1.9-2.0:1.
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9.发明公开公开(公告)号：US20240168027A1
公开(公告)日：2024-05-23
申请号：US18325792
申请日：2023-05-30
Inventor： Jun LI , Libing Song , Shuxia ZHANG , Xinyi LIAO , Suwen CHEN , Wanying QIAN
IPC: G01N33/574
CPC classification number: G01N33/5748
Abstract: The invention belongs to the technical field of biomedical testing, and particularly relates to a biomarker for diagnosis, treatment, and prognosis for hepatocellular carcinoma bone metastasis (HCC) and application thereof. The application of biomarker VAPA for preparing a reagent or a kit for diagnosis, treatment, and prognosis for HCC bone metastasis. The application of the reagent that detects VAPA expression levels in blood and tissues for preparing a reagent or kit for diagnosis, treatment, and prognosis for HCC bone metastasis. Compared with the diagnostic kits in the prior art that can only detect bone metastasis after it has occurred, the VAPA described in this invention offers a more specific and sensitive assay kit for the early prediction, diagnosis, disease progression assessment, treatment efficacy evaluation, drug guidance, and prognosis assessment of HCC bone metastasis. Additionally, the VAPA may also serve as a target for therapeutic interventions in bone metastasis.
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公开(公告)号：US20230087196A1
公开(公告)日：2023-03-23
申请号：US17817650
申请日：2022-08-04
Inventor： Jun LI , Libing Song , Yingru XU , Shuxia ZHANG , Xingui WU , Xinyi LIAO , Man LI , Suwen CHEN , Xincheng LI
IPC: A61K31/496 , A61P35/04 , C12Q1/6886
Abstract: The invention belongs to the field of biotechnology and medicine, and particularly relates to the application of an inhibitor of circIKBKB and a testing reagent thereof in diagnosis, treatment and prognosis kits of breast cancer bone metastasis. The kit includes one of RT-PCR, Q-PCR, Northern blot, FISH or ISH kits. The kit includes the primers shown in SEQ ID Nos. 1-2 in the sequence listing or the probe shown in SEQ ID NO. 3 in the sequence listing for the back-splice junction sequences for circIKBKB. An antisense oligonucleotide targeting the linker sequence of circIKBKB is used as a reagent for inhibiting the generation of circIKBKB and for the preparation of a drug for the treatment of breast cancer bone metastasis. The eIF4A3-IN-2 inhibitor is used for the preparation of a treatment for breast cancer bone metastasis drug.
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