-
公开(公告)号：US5165415A
公开(公告)日：1992-11-24
申请号：US861334
申请日：1992-03-30
申请人： David A. Wallace , Steven E. Feldon
发明人： David A. Wallace , Steven E. Feldon
CPC分类号： A61B8/4455 , A61B3/1005 , A61B8/0858 , A61B8/10 , A61B8/462 , A61F9/013
摘要： Disclosed is a completely portable, hand-held digital ultrasonic instrument about the size and shape of an ordinary pen. The housing is contoured such that it can be easily grasped in the manner of a writing pen. An activation button is located on the interior dorsal surface in close approximation to the index fingertip of the user. A liquid crystal display provides a digital readout of a thickness measurement on the barrel of the instrument housing. The instrument incorporates a 10 MHz or 20 MHz solid phase piezoelectric transducer, a microprocessor, a gate array, a hybrid analog circuit, a liquid crystal display, batteries and a removable battery cover. The 20 MHz transducer is used to measure corneal thickness and is attached to a swan neck connector which is attached to the instrument housing. The 10 MHz transducer is used for measuring axial length and it is attached to a truncated conical connector which is also attached to the instrument housing. In addition, a pinjack connector is available to link the unit to other electronic media such as a microcomputer, personal computer, or printer.
摘要翻译： 公开了一种关于普通笔的尺寸和形状的完全便携式的手持式数字超声波仪器。 外壳的轮廓是这样的，使得它可以以书写笔的方式被容易地抓住。 激活按钮位于内表面上，与用户的指尖指尖近似。 液晶显示器在仪器壳体的筒上提供厚度测量的数字读出。 该仪器采用10 MHz或20 MHz固态压电换能器，微处理器，门阵列，混合模拟电路，液晶显示器，电池和可拆卸电池盖。 20 MHz传感器用于测量角膜厚度，并连接到连接到仪器外壳的天鹅颈连接器。 10 MHz传感器用于测量轴向长度，并连接到也连接到仪器外壳的截头圆锥形连接器。 此外，可以使用pinjack连接器来将该单元链接到诸如微型计算机，个人计算机或打印机的其他电子介质。
-
公开(公告)号：US06776756B2
公开(公告)日：2004-08-17
申请号：US10137234
申请日：2002-04-30
IPC分类号： A61B316
CPC分类号： A61B3/16
摘要： For calculating the intraocular pressure (IOP) of an eye, an applanation tonometer comprises an applanator formed of an optics array, a force transducer, an image sensor, and a processing circuit configured to calculate an intraocular pressure of the eye using one or more pairs of measured force and applanated area. The tonometer is provided with a disposable tip that covers the applanator, thereby providing a replaceable, sterile and transmissive interface between the tonometer's applanator and a patient's eye. Preferably, the applanating surface has a matte finish. The tonometer calculates the intraocular pressure using a predetermined relationship between interocular pressure and the slope of the line defined by data relating to the forces required to applanate the eye and the geometry of applanated portions of the eye. In a preferred embodiment, the data acquisition is synchronous. The tonometer may be of the type of a portable, hand-held device or a device affixed to and used in conjunction with a slit-lamp design. Also disclosed is a method and device for applying a disposable tip to the applanator.
摘要翻译： 为了计算眼睛的眼内压（IOP），压平眼压计包括由光学阵列形成的压扁镜，力传感器，图像传感器和被配置为使用一对或多对来计算眼睛的眼内压的处理电路 测量力和压平面积。 眼压计设置有一个覆盖压扁器的一次性尖端，从而在眼压计的压扁器和患者的眼睛之间提供可更换的无菌和透射的界面。 优选地，平坦度表面具有无光泽的表面。 眼压计使用预期的眼压与由与压迫眼睛所需的力量和眼睛的平坦部分的几何形状相关的数据所界定的线的斜率来计算眼内压。 在优选实施例中，数据采集是同步的。 眼压计可以是便携式手持式装置或固定在狭缝灯设计上并与其结合使用的装置的类型。 还公开了一种将一次性尖端施加到压扁器的方法和装置。
-
公开(公告)号：US09694050B2
公开(公告)日：2017-07-04
申请号：US14437378
申请日：2013-10-21
IPC分类号： A61K38/16 , A61K38/00 , A61K38/17 , C12N15/113 , A61K9/00 , C07K14/705
CPC分类号： A61K38/177 , A61K9/0014 , A61K9/0048 , A61K38/1774 , C07K14/70503 , C12N15/1138 , C12N2310/113 , C12N2310/141
摘要： The present invention relates to methods of treating a condition involving excessive adipogenesis. This method relates to selecting a subject having a condition involving excessive adipogenesis and administering to the selected subject a composition comprising a Thy1 protein or polypeptide fragment thereof, or an agent that enhances Thy1 expression, under conditions effective to treat the condition. The present invention also relates to isolated nucleic acid molecules encoding a Thy1 protein or the fragment thereof and pharmaceutical formulations including such a protein or fragment thereof or an agent that enhances Thy1 expression and a pharmaceutically acceptable carrier. The present invention also relates to methods of inhibiting adipogenesis and/or decreasing adipocyte size, as well as methods of screening a candidate compound for its ability to influence adipogenesis.
-
4.发明申请THY1 (CD90) AS A NOVEL THERAPY TO CONTROL ADIPOSE TISSUE ACCUMULATION 有权THY1（CD90）作为控制ADIPOSE组织积累的新疗法公开(公告)号：US20150283205A1
公开(公告)日：2015-10-08
申请号：US14437378
申请日：2013-10-21
IPC分类号： A61K38/17 , C12N15/113 , A61K9/00
CPC分类号： A61K38/177 , A61K9/0014 , A61K9/0048 , A61K38/1774 , C07K14/70503 , C12N15/1138 , C12N2310/113 , C12N2310/141
摘要： The present invention relates to methods of treating a condition involving excessive adipogenesis. This method relates to selecting a subject having a condition involving excessive adipogenesis and administering to the selected subject a composition comprising a Thy1 protein or polypeptide fragment thereof, or an agent that enhances Thy1 expression, under conditions effective to treat the condition. The present invention also relates to isolated nucleic acid molecules encoding a Thy1 protein or the fragment thereof and pharmaceutical formulations including such a protein or fragment thereof or an agent that enhances Thy1 expression and a pharmaceutically acceptable carrier. The present invention also relates to methods of inhibiting adipogenesis and/or decreasing adipocyte size, as well as methods of screening a candidate compound for its ability to influence adipogenesis.
摘要翻译： 本发明涉及治疗涉及过量脂肪生成的病症的方法。 该方法涉及选择具有过度脂肪形成的病症的受试者，并且在有效治疗病症的条件下，向选定受试者施用包含Thy1蛋白或其多肽片段或增强Thy1表达的药物。 本发明还涉及编码Thy1蛋白或其片段的分离的核酸分子和包含这种蛋白质或其片段的药物制剂或增强Thy1表达的药剂和药学上可接受的载体。 本发明还涉及抑制脂肪形成和/或减少脂肪细胞大小的方法，以及筛选候选化合物以影响脂肪形成的能力的方法。
-
公开(公告)号：US4817432A
公开(公告)日：1989-04-04
申请号：US781257
申请日：1985-09-27
申请人： David A. Wallace , Steven E. Feldon , Gary Mezack , Douglas L. Whiting , William J. Dally , Scott A. Karns
发明人： David A. Wallace , Steven E. Feldon , Gary Mezack , Douglas L. Whiting , William J. Dally , Scott A. Karns
CPC分类号： A61B3/1005 , A61B8/10 , G01S15/101 , G01S15/88
摘要： Disclosed is a digital ultrasonic instrument for measuring the corneal thickness (often referred to as a pachymeter) and for measuring the axial length of the eye (often referred to as a biometric ruler). A number representing corneal thickness or axial length is displayed digitally on a liquid crystal display. The pachymeter incorporates a 20 MHz solid phase piezoelectric transducer, a microprocessor, a gate array, a hybrid analog receiver circuit, a liquid crystal display and four batteries. When axial length is measured, the instrument operates as a biometric ruler, a 10 MHz transducer is used and the software in the microprocessor is modified. Ultrasonic echoes generated by the transducer and various interfaces in the eye are sampled at the rate of 40 MHz which results in equal or greater sensitivity, resolution and accuracy as compared to other pachymeters and biometric rulers currently available. The 40 MHz sample rate is accomplished by use of a grey code counter and a binary counter, each of which is sampled twice after an ultrasonic echo is detected. The two grey code samples are compared to determine a valid sample period. A counter value obtained during a valid sample period is recorded in a shift register and compared to subsequent counter values corresponding to subsequent ultrasonic echoes. The apparatus for correlating ultrasonic echoes with particular counter values assures that the counter will be sampled at a point in time when the counter is stable as opposed to being in a state of transition. The apparatus allows for a counter accuracy of 25 ns.
摘要翻译： 公开了一种用于测量角膜厚度的数字超声波仪器（通常称为比表计），并用于测量眼睛的轴向长度（通常称为生物统计尺）。 表示角膜厚度或轴向长度的数字以数字方式显示在液晶显示器上。 脉宽计包含20MHz固相压电换能器，微处理器，门阵列，混合模拟接收器电路，液晶显示器和四个电池。 当测量轴向长度时，仪器作为生物统计尺寸，使用10 MHz传感器，并修改微处理器中的软件。 由传感器和眼睛各种界面产生的超声波回波以40 MHz的速率进行采样，与目前可用的其他仪器和生物统计尺相比，其灵敏度，分辨率和准确度等于或高于其他值。 通过使用灰度代码计数器和二进制计数器来实现40MHz采样率，每个计数器在检测到超声回波之后被采样两次。 比较两个灰色代码样本以确定有效的采样周期。 在有效采样周期中获得的计数器值记录在移位寄存器中，并与后续超声波回波对应的后续计数器值进行比较。 用于将超声回波与特定计数器值相关联的装置确保计数器将在计数器稳定而不是处于转换状态的时间点被采样。 该装置允许25ns的计数精度。
-
公开(公告)号：USD298856S
公开(公告)日：1988-12-06
申请号：US782026
申请日：1985-09-27
-
公开(公告)号：US4597648A
公开(公告)日：1986-07-01
申请号：US481286
申请日：1983-04-01
CPC分类号： A61B3/107
摘要： An improved keratometer instrument capable of measuring keratometric values of an eye is provided. An optical reference of a predetermined dimensional value is directed at the cornea of the eye and an optical sensor measures the same at different meridians. A computer circuit can determine whether the instrument is de-centered or de-focused relative to the eye and can derive measurements of keratometric values. The axis of astigmatism can be visually displayed to the surgeon during an operation.
摘要翻译： 提供了能够测量眼睛角膜测量值的改进的角膜曲率计仪器。 预定尺寸值的光学参考指向眼睛的角膜，并且光学传感器在不同的子午线测量相同。 计算机电路可以确定仪器是否相对于眼睛去焦点或去焦点，并且可导出角膜测量值的测量值。 在操作期间，可以将视像轴视觉显示给外科医生。
-
公开(公告)号：US5732221A
公开(公告)日：1998-03-24
申请号：US403551
申请日：1995-03-14
申请人： Steven E. Feldon , Jai P. Agrawal
发明人： Steven E. Feldon , Jai P. Agrawal
CPC分类号： G06F17/243 , G06Q50/24
摘要： System and methods for generating written reports based on succinct input from a user. A method of the present invention comprises entering a first mode for initialization; defining menus; entering a second mode for receiving information; entering information using the defined menus; interpreting the entered information; and generating a written report in response to the interpreting step. A system (100) of the present invention comprises a portable computer system having a memory (102), a processor (101), a detachable keyboard (107), a screen (104), and a pen (105). Ancillary information is entered with the keyboard which is then detached. Subsequent information is documented by selecting appropriate items from the defined menus; alternatively, the information can be written on the screen with the pen. The processor is programmed to interpret the inputs and generate a report. The report may be printed on a printer (108), stored on a storage device, and/or transferred to another system.
摘要翻译： 基于用户简洁的输入生成书面报告的系统和方法。 本发明的方法包括：进入初始化模式; 定义菜单; 进入接收信息的第二种模式; 使用定义的菜单输入信息; 解释输入的信息; 并响应于解释步骤生成书面报告。 本发明的系统（100）包括具有存储器（102），处理器（101），可拆卸键盘（107），屏幕（104）和笔（105）的便携式计算机系统。 使用随后分离的键盘输入辅助信息。 通过从定义的菜单中选择适当的项目来记录后续信息; 或者，信息可以用笔写在屏幕上。 处理器被编程为解释输入并生成报告。 报告可以打印在存储在存储设备上的打印机（108）上，和/或被传送到另一个系统。
-
公开(公告)号：US4747296A
公开(公告)日：1988-05-31
申请号：US781240
申请日：1985-09-27
CPC分类号： A61B3/16
摘要： Disclosed is a battery powered, hand-held self-contained electronic tonometer with a digital readout for displaying pressure in millimeters of mercury. The tonometer includes a transducer which is a solid state pressure sensitive element and which produces a voltage proportional to intraocular pressure. An electrical waveform is produced by gently bringing the transducer in contact with the cornea. The waveform is converted to a digital signal and processed by a single chip microprocessor. The baseline of a reference signal is nulled by equalizing the charges on two capacitors on the inputs of two differential amplifiers. Equalizing the differential inputs of the two amplifier stages results in a gain of zero and removes any carrier signal. Microprocessor software detects the baseline condition established by equalizing the differential inputs. The microprocessor then looks for a series of valid measurements and calculates the average intraocular pressure along with an estimate of reliability. This average value and the reliability indicator are displayed on a liquid crystal display.
摘要翻译： 公开了一种电池供电的手持式独立电子眼压计，具有用于显示毫米汞柱压力的数字读数器。 眼压计包括作为固态压敏元件并且产生与眼内压成比例的电压的换能器。 通过轻轻地使传感器与角膜接触来产生电波形。 波形转换为数字信号，并由单片微处理器处理。 通过对两个差分放大器的输入端上的两个电容器的电荷进行均衡，使参考信号的基线为零。 均衡两个放大器级的差分输入导致增益为零并且去除任何载波信号。 微处理器软件检测通过均衡差分输入建立的基线条件。 然后，微处理器寻找一系列有效的测量值，并计算平均眼压以及可靠性估计值。 该平均值和可靠性指示器显示在液晶显示器上。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.019 秒)
