公开(公告)号：US20160039790A1

公开(公告)日：2016-02-11

申请号：US14777492

申请日：2014-03-13

Applicant: Wenying CHAI ,  Curt A. DVORAK ,  Wendy ECCLES ,  James P. EDWARDS ,  Steven D. GOLDBERG ,  Paul J. KRAWCZUK ,  Alec D. LEBSACK ,  Jing LIU ,  Daniel J. PIPPEL ,  Zachary S. SALES ,  Virginia M. TANIS ,  Mark S. TICHENOR ,  John J.M. WIENER ,  JANSSEN PHARMACEUTICA NV

Inventor： Wenying Chai ,  Curt A. Dvorak ,  Wendy Eccles ,  James P. Edwards ,  Steven D. Goldberg ,  Paul J. Krawczuk ,  Alec D. Lebsack ,  Jing Liu ,  Daniel J. Pippel ,  Zachary S. Sales ,  Virginia M. Tanis ,  Mark S. Tichenor ,  John J. M. Wiener

IPC: C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D403/12

CPC classification number: C07D401/12 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

Abstract: The present invention relates to compounds of Formula (I), and solvates, hydrates, and pharmaceutically acceptable salts thereof, wherein X1, X1′, X1″, R1, R2 and R3 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

公开(公告)号：US20160046600A1

公开(公告)日：2016-02-18

申请号：US14777481

申请日：2014-03-13

Applicant: Wenying CHAI ,  Charlotte DECKHUT ,  Curt A. DVORAK ,  Wendy ECCLES ,  James P. EDWARDS ,  Steven D. GOLDBERG ,  Paul J. KRAWCZUK ,  Alec D. LEBSACK ,  Jing LIU ,  Virginia M. TANIS ,  Kyle T. TARANTINO ,  JANSSEN PHARMACEUTICA NV

Inventor： Wenying Chai ,  Charlotte Deckhut ,  Curt A. Dvorak ,  Wendy Eccles ,  James P. Edwards ,  Steven D. Goldberg ,  Paul J. Krawczuk ,  Alec D. Lebsack ,  Jing Liu ,  Virginia M. Tanis ,  Kyle T. Tarantino

IPC: C07D401/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14 ,  C07D413/14 ,  C07D401/14

CPC classification number: C07D417/14 ,  A61K31/428 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12

Abstract: The present invention relates to compounds of Formula (I), and solvates, hydrates, and pharmaceutically acceptable salts thereof, wherein ring A, R1, R5 and R6 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

公开(公告)号：US07683180B2

公开(公告)日：2010-03-23

申请号：US10124745

申请日：2002-04-16

Applicant: Robert H. Grubbs ,  Donald W. Ward ,  Thomas J. Seiders ,  Steven D. Goldberg

Inventor： Robert H. Grubbs ,  Donald W. Ward ,  Thomas J. Seiders ,  Steven D. Goldberg

IPC: C07F15/00 ,  C07F7/02 ,  B01J31/00 ,  C08F4/80

CPC classification number: C07F15/0046

Abstract: The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions, and for enantioselective reactions in particular. The synthesis of these complexes and details of their use as catalysts is also provided.

Abstract translation: 本发明涉及第8族过渡金属卡宾络合物用作烯烃交叉复分解反应的催化剂，特别涉及对映选择性反应。 还提供了这些络合物的合成及其用作催化剂的细节。