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1.发明授权Orvinol and thevinol derivatives useful in the treatment of drug and alcohol abuse 有权Orvinol和乙醇衍生物可用于治疗药物和酒精滥用公开(公告)号：US09051334B2
公开(公告)日：2015-06-09
申请号：US14131361
申请日：2012-07-05
Applicant: John Lewis , Stephen Husbands
Inventor： John Lewis , Stephen Husbands
IPC: A61K31/485 , C07D489/12 , C07D491/08
CPC classification number: C07D489/12 , A61K31/4748 , A61K31/485 , C07D489/10 , C07D491/08
Abstract: The invention provides orvinol and thevinol compounds useful for the treatment of drug and alcohol abuse, the compounds being particularly useful for the prevention of relapse in recovering addicts.
Abstract translation: 本发明提供了可用于治疗药物和酒精滥用的orvinol和乙醇化合物，该化合物特别可用于预防复发成瘾者的复发。
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公开(公告)号：US08865750B2
公开(公告)日：2014-10-21
申请号：US13458233
申请日：2012-04-27
Applicant: Richard Neubig , Levi Blazer , Stephen Husbands , Scott Larsen , John Traynor
Inventor： Richard Neubig , Levi Blazer , Stephen Husbands , Scott Larsen , John Traynor
IPC: A01N43/82 , A61K31/41 , C07D417/00 , C07D513/00 , A61K31/433 , C07D417/06 , C07D285/08
CPC classification number: C07D417/06 , A61K31/433 , C07D285/08
Abstract: The invention relates to compositions having RGS (regulator of G-protein Signaling) inhibiting activity, and methods of use thereof. In some embodiments, RGS-inhibiting compositions find use in research on or treatment of disease states (e.g., diabetes, epilepsy, neuropathic pain, depression and other diseases).
Abstract translation: 本发明涉及具有RGS（G蛋白信号调节剂）抑制活性的组合物及其使用方法。 在一些实施方案中，抑制RGS的组合物可用于研究或治疗疾病状态（例如，糖尿病，癫痫，神经性疼痛，抑郁症和其它疾病）。
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3.发明申请ORVINOL AND THEVINOL DERIVATIVES USEFUL IN THE TREATMENT OF DRUG AND ALCOHOL ABUSE 有权用于治疗药物和酒精滥用的ORVINOL和THEVINOL衍生物公开(公告)号：US20140213603A1
公开(公告)日：2014-07-31
申请号：US14131361
申请日：2012-07-05
Applicant: John Lewis , Stephen Husbands
Inventor： John Lewis , Stephen Husbands
IPC: C07D491/08
CPC classification number: C07D489/12 , A61K31/4748 , A61K31/485 , C07D489/10 , C07D491/08
Abstract: The invention provides orvinol and thevinol compounds useful for the treatment of drug and alcohol abuse, the compounds being particularly useful for the prevention of relapse in recovering addicts.
Abstract translation: 本发明提供了可用于治疗药物和酒精滥用的orvinol和乙醇化合物，该化合物特别可用于预防复发成瘾者的复发。
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公开(公告)号：US20120277273A1
公开(公告)日：2012-11-01
申请号：US13458233
申请日：2012-04-27
Applicant: Richard Neubig , Levi Blazer , Stephen Husbands , Scott Larsen , John Traynor
Inventor： Richard Neubig , Levi Blazer , Stephen Husbands , Scott Larsen , John Traynor
IPC: A61K31/433 , C12N5/071 , C07D285/08 , A61P25/28 , A61P25/00 , A61P25/16 , C07D417/06 , A61P25/24
CPC classification number: C07D417/06 , A61K31/433 , C07D285/08
Abstract: The invention relates to compositions having RGS (regulator of G-protein Signaling) inhibiting activity, and methods of use thereof. In some embodiments, RGS-inhibiting compositions find use in research on or treatment of disease states (e.g., diabetes, epilepsy, neuropathic pain, depression and other diseases).
Abstract translation: 本发明涉及具有RGS（G蛋白信号调节剂）抑制活性的组合物及其使用方法。 在一些实施方案中，抑制RGS的组合物可用于研究或治疗疾病状态（例如，糖尿病，癫痫，神经性疼痛，抑郁症和其它疾病）。
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