公开(公告)号：US06486320B2

公开(公告)日：2002-11-26

申请号：US09951505

申请日：2001-09-14

申请人： Stefanie Leue ,  Stéphanie Garçon ,  Andrew-Elliot Greene ,  Yves Génisson ,  Patrick Léon

发明人： Stefanie Leue ,  Stéphanie Garçon ,  Andrew-Elliot Greene ,  Yves Génisson ,  Patrick Léon

IPC分类号： C07D49114

CPC分类号： C07D215/227 ,  C07C69/734 ,  C07D215/18 ,  C07D309/32 ,  C07D405/12 ,  C07D471/04

摘要： The present invention relates to a novel process for preparation of camptothecin and of its derivatives by convergent synthesis starting from a 3-(aminomethyl)quinoline derivative and 5-hydroxy-5-ethyl-6-oxo-5,6-dihydropyrancarboxylic acid and to the intermediates obtained.