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公开(公告)号：US20120208818A1
公开(公告)日：2012-08-16
申请号：US13269697
申请日：2011-10-10
Applicant: Amy M. Elder , Shomir Ghosh , Sian Griffiths , Prakash Raman , Francois Soucy , Kevin Sprott , Qing Ye
Inventor： Amy M. Elder , Shomir Ghosh , Sian Griffiths , Prakash Raman , Francois Soucy , Kevin Sprott , Qing Ye
IPC: A61K31/5377 , C07D405/14 , A61K31/517 , A61K31/4439 , A61K31/4184 , A61K31/416 , A61K31/502 , C07D471/04 , A61K31/4725 , C07D401/14 , C07D403/14 , C07D413/14 , A61P29/00 , A61P19/02 , A61P25/00 , A61P9/10 , A61P3/10 , A61K31/435
CPC classification number: C07D207/14 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.
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公开(公告)号：US08067415B2
公开(公告)日：2011-11-29
申请号：US12084353
申请日：2006-10-26
Applicant: Amy M. Elder , Shomir Ghosh , Sian Griffiths , Prakash Raman , Francois Soucy , Kevin Sprott , Qing Ye
Inventor： Amy M. Elder , Shomir Ghosh , Sian Griffiths , Prakash Raman , Francois Soucy , Kevin Sprott , Qing Ye
IPC: A61K31/505 , A61K31/498 , A61K31/435 , A61K31/4184 , C07D487/22 , C07D487/12 , C07D241/00 , C07D491/14 , C07D491/22 , C07D235/04
CPC classification number: C07D207/14 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: The present invention provides compounds of general formula (I) or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.
Abstract translation: 本发明提供了通式（I）的化合物或其药学上可接受的盐，其中X，n，Y和R 1通常在本文中以亚组定义。 本发明的化合物是CCR2的抑制剂，因此可用于治疗各种炎症，过敏和自身免疫疾病，病症或病症。
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Patent Agency Ranking
公开(公告)号：US20090197884A1
公开(公告)日：2009-08-06
申请号：US12084356
申请日：2006-10-26
Applicant: Shomir Ghosh , Prakash Raman , Kevin Sprott , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
Inventor： Shomir Ghosh , Prakash Raman , Kevin Sprott , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
IPC: A61K31/454 , C07D401/06 , C07D401/14 , C07D413/14 , C07D405/14 , A61P29/00 , A61K31/4545 , A61K31/517 , A61K31/423 , A61K31/416 , A61K31/5377
CPC classification number: C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.
Abstract translation: 本发明提供通式I的化合物或其药学上可接受的盐，其中X，n，Y和R 1通常在本文中定义并在亚组中。 本发明的化合物是CCR2的抑制剂，因此可用于治疗各种炎症，过敏和自身免疫疾病，病症或病症。
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公开(公告)号：US20100016289A1
公开(公告)日：2010-01-21
申请号：US12084357
申请日：2006-10-26
Applicant: Kevin Sprott , Prakash Raman , Shomir Ghosh , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
Inventor： Kevin Sprott , Prakash Raman , Shomir Ghosh , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
IPC: A61K31/55 , C07D403/02 , C07D413/14 , A61P9/00 , C07D403/14 , A61P3/10 , A61P37/00 , A61K31/517
CPC classification number: C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14
Abstract: The present invention provides compounds of general formula I: (I) or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.
Abstract translation: 本发明提供了通式I的化合物：（I）或其药学上可接受的盐，其中X，n，Y和R 1通常在本文中以亚组定义。 本发明的化合物是CCR2的抑制剂，因此可用于治疗各种炎症，过敏和自身免疫疾病，病症或病症。
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公开(公告)号：US20090163497A1
公开(公告)日：2009-06-25
申请号：US12084353
申请日：2006-10-26
Applicant: Amy M. Elder , Shomir Ghosh , Sian Griffiths , Prakash Raman , Francois Soucy , Kevin Sprott , Qing Ye
Inventor： Amy M. Elder , Shomir Ghosh , Sian Griffiths , Prakash Raman , Francois Soucy , Kevin Sprott , Qing Ye
IPC: A61K31/5377 , C07D403/04 , C07D413/14 , C07D403/14 , C07D409/14 , C07D405/14 , A61K31/498 , A61K31/517 , A61K31/435 , A61K31/4725 , A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/421 , A61P19/02 , A61P17/00 , A61P29/00 , A61P9/10 , A61P3/10
CPC classification number: C07D207/14 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: The present invention provides compounds of general formula (I) or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.
Abstract translation: 本发明提供了通式（I）的化合物或其药学上可接受的盐，其中X，n，Y和R 1通常在本文中以亚组定义。 本发明的化合物是CCR2的抑制剂，因此可用于治疗各种炎症，过敏和自身免疫疾病，病症或病症。
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公开(公告)号：US20120214807A1
公开(公告)日：2012-08-23
申请号：US13281482
申请日：2011-10-26
Applicant: Shomir Ghosh , Prakash Raman , Kevin Sprott , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
Inventor： Shomir Ghosh , Prakash Raman , Kevin Sprott , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
IPC: A61K31/5377 , A61K31/517 , A61K31/435 , A61K31/4725 , A61K31/454 , A61K31/453 , A61K31/4439 , C07D471/04 , C07D405/14 , C07D413/14 , C07D405/04 , C07D409/14 , A61P29/00 , A61P19/02 , A61P25/00 , A61P9/10 , A61P3/10 , A61K31/5025
CPC classification number: C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.
Abstract translation: 本发明提供通式I的化合物或其药学上可接受的盐，其中X，n，Y和R 1通常在本文中定义并在亚组中。 本发明的化合物是CCR2的抑制剂，因此可用于治疗各种炎症，过敏和自身免疫疾病，病症或病症。
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公开(公告)号：US08067457B2
公开(公告)日：2011-11-29
申请号：US12084356
申请日：2006-10-26
Applicant: Shomir Ghosh , Prakash Raman , Kevin Sprott , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
Inventor： Shomir Ghosh , Prakash Raman , Kevin Sprott , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
IPC: C07D487/04 , C07D413/14 , C07D405/14 , C07D405/04 , A61K31/517 , A61K31/4725 , A61K31/4439 , A61K31/4375 , A61K31/423 , A61K31/4184 , A61K31/416 , A61K31/4025
CPC classification number: C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.
Abstract translation: 本发明提供通式I的化合物或其药学上可接受的盐，其中X，n，Y和R 1通常在本文中定义并在亚组中。 本发明的化合物是CCR2的抑制剂，因此可用于治疗各种炎症，过敏和自身免疫疾病，病症或病症。
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