Polypeptide, the conjugate thereof with doxorubicine and a pharmaceutical composition based thereon
    2.
    发明申请
    Polypeptide, the conjugate thereof with doxorubicine and a pharmaceutical composition based thereon 失效
    多肽,其与多柔比星的缀合物和基于其的药物组合物

    公开(公告)号:US20050070465A1

    公开(公告)日:2005-03-31

    申请号:US10872827

    申请日:2004-10-14

    摘要: The inventive polypeptide is embodied in the form of a similar fragment of the epidermal growth factor of aminoacid ranging from 21 to 31 and capable of efficiently binding with the receptor of the epidermal growth factor as a vector for the directed supply of anticancer agent to tumour cells. The inventive conjugate of said polypeptide contains doxorubicine and has a selective action on cancer tumours and can substantially reduce the resistance of tumour cells with respect to the anticancer agents, the conjugated parts of said agents being binded with the aid of a chemical bond which is unstable in relation to acid hydrolysis. The inventive pharmaceutical composition comprises an efficient quantity of conjugate and a carrier which is fit for intravenous injection. Said invention can be used for medicine for treating cancer patients.

    摘要翻译: 本发明的多肽以21至31位的氨基酸表皮生长因子的类似片段的形式实施,并且能够与表皮生长因子的受体有效结合,作为向肿瘤细胞定向供应抗癌剂的载体 。 所述多肽的本发明缀合物含有多柔比星并且对癌症肿瘤具有选择性作用,并且可以显着降低肿瘤细胞相对于抗癌剂的抗性,所述药物的共轭部分借助于不稳定的化学键而结合 关于酸水解。 本发明的药物组合物包含适合静脉注射的有效量的缀合物和载体。 本发明可用于治疗癌症患者的药物。