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公开(公告)号：US10201532B2
公开(公告)日：2019-02-12
申请号：US13989600
申请日：2011-11-25
Applicant: Senthilkumar Udayampalayam Palanisamy , Maneesh Paul-Satyaseela , Shridhar Narayanan , Gopalan Balasubramanian , Aravind Appu , Senthilnathan Manickam , Hariharan Periasamy
Inventor： Senthilkumar Udayampalayam Palanisamy , Maneesh Paul-Satyaseela , Shridhar Narayanan , Gopalan Balasubramanian , Aravind Appu , Senthilnathan Manickam , Hariharan Periasamy
IPC: A61K31/431 , C07D499/883 , A61K31/397 , A61K31/4025 , A61K31/496 , A61K31/542 , C07D499/00 , C12Q1/44
Abstract: Described herein are compounds and their use in the treatment of infections. The compound of formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, solvates, pharmaceutically acceptable salts and pharmaceutical compositions described herein are also useful as β-lactamase inhibitors, which restore or enhance the antibiotic spectrum of a suitable antibiotic agent. The compounds of formula (I) act as inhibitors of β-lactamases. These compounds restore/potentiate the activities of β-lactam antibiotics against carbapenemases. These compounds find use in diagnostic method for detecting β-lactamases.Formula (I)
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公开(公告)号：US20110136777A1
公开(公告)日：2011-06-09
申请号：US13054262
申请日：2009-08-20
Applicant: Senthilkumar Udayampalayam Palanisamy , Sivakumar Balasubramanian , Manimaran Arasappan , Meenakshi Sundaram Soma Sundaram , Sureshkumar Kanagaraj , Mohan Singaravel
Inventor： Senthilkumar Udayampalayam Palanisamy , Sivakumar Balasubramanian , Manimaran Arasappan , Meenakshi Sundaram Soma Sundaram , Sureshkumar Kanagaraj , Mohan Singaravel
IPC: A61K31/545 , C07D501/16
CPC classification number: C07D501/36
Abstract: Polymorphs of Ceftiofur sodium as a crystalline product and a process for the preparation of polymorphs of crystalline Ceftiofur sodium of formula (I).
Abstract translation: 作为结晶产物的头孢噻呋钠的多晶型物和制备式（I）的结晶头孢噻呋钠的多晶型物的方法。
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公开(公告)号：US20120253066A1
公开(公告)日：2012-10-04
申请号：US13512243
申请日：2010-12-16
Applicant: Khadangale Bhausaheb Pandharinath , Kahandal Bhimraj Suryabhan , Suresh Pandian Pandi , Senthilkumar Udayampalayam Palanisamy , Sureshkumar Kanagaraj , Pandiarajan Sivasubramanian
Inventor： Khadangale Bhausaheb Pandharinath , Kahandal Bhimraj Suryabhan , Suresh Pandian Pandi , Senthilkumar Udayampalayam Palanisamy , Sureshkumar Kanagaraj , Pandiarajan Sivasubramanian
IPC: C07C61/35
CPC classification number: C07B63/04 , A61K31/197 , C07C323/59 , C07C2601/02
Abstract: The present invention relates to an improved process for the preparation of Cilastatin Sodium of formula (I), having mesityl oxide content less than 2000 ppm and more than 1 ppm. (Formula I) (I)
Abstract translation: 本发明涉及制备式（I）的西司他丁钠的改进方法，其具有小于2000ppm且大于1ppm的平均氧化物含量。 （式I）（I）
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公开(公告)号：US08470809B2
公开(公告)日：2013-06-25
申请号：US12903751
申请日：2010-10-13
Applicant: Sureshkumar Kanagaraj , Sivakumar Balasubramanian , Senthilkumar Udayampalayam Palanisamy
IPC: A61K31/546
CPC classification number: C07D501/36 , A61K31/546
Abstract: The present invention relates to novel polymorph of Ceftiofur sodium as a crystalline product. The present invention also provides a process for the preparation of novel polymorphs of crystalline Ceftiofur sodium of formula (I).
Abstract translation: 本发明涉及头孢噻呋钠作为结晶产物的新型多晶型物。 本发明还提供了制备式（I）的结晶头孢噻呋钠的新型多晶型物的方法。
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公开(公告)号：US08431562B2
公开(公告)日：2013-04-30
申请号：US13054262
申请日：2009-08-20
Applicant: Senthilkumar Udayampalayam Palanisamy , Sivakumar Balasubramanian , Manimaran Arasappan , Meenakshi Sundaram Soma Sundaram , Sureshkumar Kanagaraj , Mohan Singaravel
Inventor： Senthilkumar Udayampalayam Palanisamy , Sivakumar Balasubramanian , Manimaran Arasappan , Meenakshi Sundaram Soma Sundaram , Sureshkumar Kanagaraj , Mohan Singaravel
IPC: C07D501/36 , A61K31/546
CPC classification number: C07D501/36
Abstract: Polymorphs of Ceftiofur sodium as a crystalline product and a process for the preparation of polymorphs of crystalline Ceftiofur sodium of formula (I).
Abstract translation: 作为结晶产物的头孢噻呋钠的多晶型物和制备式（I）的结晶头孢噻呋钠的多晶型物的方法。
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Patent Agency Ranking
公开(公告)号：US08293924B2
公开(公告)日：2012-10-23
申请号：US12733817
申请日：2008-09-30
IPC: C07D487/02
CPC classification number: C07D477/20
Abstract: An improved process for the preparation of carbapenem antibiotic of formula (I) or its hydrate is provided.
Abstract translation: 提供了制备式（I）的碳青霉烯类抗生素或其水合物的改进方法。
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公开(公告)号：US20120035357A1
公开(公告)日：2012-02-09
申请号：US13146161
申请日：2010-02-25
Applicant: Sureshkumar Kanagaraj , Senthilkumar Udayampalayam Palanisamy , Maruthi Chandrasekhara Kishor Addanki , Vinod Babu Dasari , John Bosco John Peter , Karthikeyan Lakshmi Narayanan
Inventor： Sureshkumar Kanagaraj , Senthilkumar Udayampalayam Palanisamy , Maruthi Chandrasekhara Kishor Addanki , Vinod Babu Dasari , John Bosco John Peter , Karthikeyan Lakshmi Narayanan
IPC: C07D477/20
CPC classification number: C07D477/06 , C07D207/12 , C07D277/20
Abstract: The present invention relates to an improved process for the preparation of the carbapenem antibiotic of formula (I) or its salts, hydrates and esters. The present invention further provides novel crystalline form of compound of general formula (III), wherein R3 is p-nitrobenzyloxy carbonyl.
Abstract translation: 本发明涉及制备式（I）的碳青霉烯类抗生素或其盐，水合物和酯的改进方法。 本发明还提供通式（III）化合物的新结晶形式，其中R 3是对硝基苄氧基羰基。
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公开(公告)号：US20110059933A1
公开(公告)日：2011-03-10
申请号：US12903751
申请日：2010-10-13
Applicant: Sureshkumar KANAGARAJ , Sivakumar BALASUBRAMANIAN , Senthilkumar UDAYAMPALAYAM PALANISAMY
IPC: A61K31/546 , C07D501/60 , A61P31/04
CPC classification number: C07D501/36 , A61K31/546
Abstract: The present invention relates to novel polymorph of Ceftiofur sodium as a crystalline product. The present invention also provides a process for the preparation of novel polymorphs of crystalline Ceftiofur sodium of formula (I).
Abstract translation: 本发明涉及头孢噻呋钠作为结晶产物的新型多晶型物。 本发明还提供了制备式（I）的结晶头孢噻呋钠的新颖多晶型物的方法。
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公开(公告)号：US20140057888A1
公开(公告)日：2014-02-27
申请号：US13989600
申请日：2011-11-25
Applicant: Senthilkumar Udayampalayam Palanisamy , Maneesh Paul-Satyaseela , Shridhar Narayanan , Gopalan Balasubramanian , Aravind Appu , Senthilnathan Manickam , Hariharam Periasamy
Inventor： Senthilkumar Udayampalayam Palanisamy , Maneesh Paul-Satyaseela , Shridhar Narayanan , Gopalan Balasubramanian , Aravind Appu , Senthilnathan Manickam , Hariharam Periasamy
IPC: A61K31/431 , C12Q1/44 , A61K31/496 , A61K31/542 , A61K31/4025 , C07D499/00 , A61K31/397
CPC classification number: A61K31/431 , A61K31/397 , A61K31/4025 , A61K31/496 , A61K31/542 , C07D499/00 , C07D499/883 , C12Q1/44
Abstract: Described herein are compounds and their use in the treatment of infections. The compound of formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, solvates, pharmaceutically acceptable salts and pharmaceutical compositions described herein are also useful as β-lactamase inhibitors, which restore or enhance the antibiotic spectrum of a suitable antibiotic agent. The compounds of formula (I) act as inhibitors of β-lactamases. These compounds restore/potentiate the activities of β-lactam antibiotics against carbapenemases. These compounds find use in diagnostic method for detecting β-lactamases.Formula (I)
Abstract translation: 本文描述的是化合物及其在治疗感染中的用途。 本文所述的式（I）化合物，其衍生物，类似物，互变异构体形式，立体异构体，多晶型物，溶剂合物，药学上可接受的盐和药物组合物也可用作β-内酰胺酶抑制剂，其恢复或增强合适的抗生素的抗生素谱 代理商 式（I）化合物作为β-内酰胺酶的抑制剂。 这些化合物恢复/增强β-内酰胺抗生素对碳青霉烯酶的活性。 这些化合物可用于检测β-内酰胺酶的诊断方法。 式（I）
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公开(公告)号：US20100311984A1
公开(公告)日：2010-12-09
申请号：US12733817
申请日：2008-09-30
IPC: C07D477/20
CPC classification number: C07D477/20
Abstract: An improved process for the preparation of carbapenem antibiotic of formula (I) or its hydrate is provided.
Abstract translation: 提供了制备式（I）或其水合物的碳青霉烯类抗生素的改进方法。
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