公开(公告)号：US20240076368A1

公开(公告)日：2024-03-07

申请号：US18465093

申请日：2023-09-11

Applicant: Scipher Medicine Corporation

Inventor： Viatcheslav R. AKMAEV ,  Theodore R. MELLORS

IPC: C07K16/24 ,  A61K38/17 ,  A61P19/02 ,  G16B20/20 ,  G16B40/20 ,  G16H20/10 ,  G16H50/20

CPC classification number: C07K16/241 ,  A61K38/1793 ,  A61P19/02 ,  G16B20/20 ,  G16B40/20 ,  G16H20/10 ,  G16H50/20

Abstract: Presented herein are systems and methods for developing classifiers useful for predicting response to particular treatments. For example, in some embodiments, the present disclosure provides methods of treating subjects suffering from an autoimmune disorder, the method comprising: administering an anti-TNF therapy to subjects who have been determined to be responsive via a classifier established to distinguish between responsive and non-responsive prior subjects in a cohort who have received the anti-TNF therapy. For example, in some embodiments, the present disclosure provides methods of treating subjects suffering from an autoimmune disorder during therapeutic treatment, the method comprising: identifying responsive and non-responsive prior subjects over a time period beginning from the administering of the anti-TNF therapy.

公开(公告)号：US20220056121A1

公开(公告)日：2022-02-24

申请号：US17517496

申请日：2021-11-02

Applicant: Scipher Medicine Corporation

Inventor： Keith J. JOHNSON ,  Susan Dina GHIASSIAN

IPC: C07K16/24 ,  G16H50/30 ,  A61P19/02 ,  C12Q1/6827 ,  G16B20/20 ,  G16B40/30 ,  G16B45/00 ,  C12Q1/6851 ,  C12Q1/6883

Abstract: Methods and systems for administering anti-TNF therapy to subjects who have been determined to display a gene expression response signature established to distinguish between responsive and non-responsive prior subjects who have received the anti-TNF therapy.

公开(公告)号：US20240355416A1

公开(公告)日：2024-10-24

申请号：US18753994

申请日：2024-06-25

Applicant: Scipher Medicine Corporation

Inventor： Susan GHIASSIAN ,  Theodore R. MELLORS ,  Marc SANTOLINI ,  Asher AMELI ,  Nancy SCHOENBRUNNER ,  Viatcheslav R. AKMAEV ,  Keith J. JOHNSON

IPC: G16B20/20 ,  A61K38/17 ,  A61P19/02 ,  A61P37/06 ,  C07K16/24 ,  G16B40/00 ,  G16H10/60 ,  G16H20/10 ,  G16H50/20 ,  G16H50/70

CPC classification number: G16B20/20 ,  A61K38/1793 ,  A61P19/02 ,  A61P37/06 ,  C07K16/241 ,  G16B40/00 ,  G16H10/60 ,  G16H20/10 ,  G16H50/20 ,  G16H50/70 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/76

Abstract: Presented herein are systems and methods for developing classifiers useful for predicting response to particular treatments. For example, in some embodiments, the present disclosure provides a method of treating subjects suffering from an autoimmune disorder, the method comprising administering an alternative to anti-TNF therapy to subjects who have been determined to be non-responsive via a classifier established to distinguish between responsive and non-responsive prior subjects in a cohort who have received the anti-TNF therapy.

公开(公告)号：US20240203555A1

公开(公告)日：2024-06-20

申请号：US18544214

申请日：2023-12-18

Applicant: Scipher Medicine Corporation

Inventor： Susan Ghiassian ,  Viatcheslav R. AKMAEV ,  Ivan VOITALOV

IPC: G16H20/10 ,  A61K45/06 ,  C07K16/24 ,  G16B20/20 ,  A61K39/00

CPC classification number: G16H20/10 ,  A61K45/06 ,  C07K16/241 ,  G16B20/20 ,  A61K2039/505

Abstract: Described are methods and systems for identifying a disease gene expression signature determined to revert a disease gene expression signature in a subject suffering from a disease to a non-diseased expression signature (e.g., gene expression of a non-diseased subject). Also provided herein are methods of designing a study (e.g., a clinical trial) comprising identifying diseased subjects who exhibit a quantifiable change in the disease gene expression signature towards gene expression of a non-diseased subject.

公开(公告)号：US11987620B2

公开(公告)日：2024-05-21

申请号：US17517496

申请日：2021-11-02

Applicant: Scipher Medicine Corporation

Inventor： Keith J. Johnson ,  Susan Ghiassian

IPC: C07K16/24 ,  A61P19/02 ,  C12Q1/6827 ,  C12Q1/6851 ,  C12Q1/6883 ,  G16B20/20 ,  G16B40/30 ,  G16B45/00 ,  G16H50/30

CPC classification number: C07K16/241 ,  A61P19/02 ,  C12Q1/6827 ,  C12Q1/6851 ,  C12Q1/6883 ,  G16B20/20 ,  G16B40/30 ,  G16B45/00 ,  G16H50/30 ,  C12Q2600/158 ,  G01N2800/52 ,  G01N2800/60

Abstract: Methods of treating a subject suffering from an autoimmune disease, disorder, or condition with an alternative to anti-TNF therapy.

公开(公告)号：US20220375541A1

公开(公告)日：2022-11-24

申请号：US17881441

申请日：2022-08-04

Applicant: Scipher Medicine Corporation

Inventor： Susan GHIASSIAN ,  Theodore R. MELLORS ,  Marc SANTOLINI ,  Asher AMELI ,  Nancy SCHOENBRUNNER ,  Viatcheslav R. AKMAEV ,  Keith J. JOHNSON

IPC: G16B20/20 ,  G16H10/60 ,  G16H50/70 ,  A61P37/06 ,  G16H50/20 ,  G16H20/10 ,  A61P19/02 ,  G16B40/00 ,  A61K38/17 ,  C07K16/24

Abstract: Presented herein are systems and methods for developing classifiers useful for predicting response to particular treatments. For example, in some embodiments, the present disclosure provides a method of treating subjects suffering from an autoimmune disorder, the method comprising administering an alternative to anti-TNF therapy to subjects who have been determined to be non-responsive via a classifier established to distinguish between responsive and non-responsive prior subjects in a cohort who have received the anti-TNF therapy.

公开(公告)号：US20240153580A1

公开(公告)日：2024-05-09

申请号：US18544115

申请日：2023-12-18

Applicant: Scipher Medicine Corporation

Inventor： Susan Ghiassian ,  Viatcheslav R. AKMAEV ,  Ivan VOITALOV

IPC: G16B25/10 ,  G16B40/00

CPC classification number: G16B25/10 ,  G16B40/00

Abstract: Described are methods and systems for identifying a target for therapy and treating a subject that exhibits a disease gene expression signature, comprising identifying and administering a therapy determined to revert a disease gene expression signature in a subject suffering from a disease, disorder, or condition toward a non-diseased expression signature (e.g., disease gene expression signature of a non-diseased subject).

公开(公告)号：US20230386606A1

公开(公告)日：2023-11-30

申请号：US18450222

申请日：2023-08-15

Applicant: Scipher Medicine Corporation

Inventor： Susan GHIASSIAN ,  Theodore R. MELLORS ,  Marc SANTOLINI ,  Asher AMELI ,  Nancy SCHOENBRUNNER ,  Viatcheslav R. AKMAEV ,  Keith J. JOHNSON

IPC: G16B20/20 ,  G16H10/60 ,  G16H50/70 ,  A61P37/06 ,  G16H50/20 ,  G16H20/10 ,  A61P19/02 ,  G16B40/00 ,  A61K38/17 ,  C07K16/24

CPC classification number: G16B20/20 ,  G16H10/60 ,  G16H50/70 ,  A61P37/06 ,  G16H50/20 ,  G16H20/10 ,  A61P19/02 ,  G16B40/00 ,  A61K38/1793 ,  C07K16/241 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/76

Abstract: Presented herein are systems and methods for developing classifiers useful for predicting response to particular treatments. For example, in some embodiments, the present disclosure provides a method of treating subjects suffering from an autoimmune disorder, the method comprising administering an alternative to anti-TNF therapy to subjects who have been determined to be non-responsive via a classifier established to distinguish between responsive and non-responsive prior subjects in a cohort who have received the anti-TNF therapy.

公开(公告)号：US11783913B2

公开(公告)日：2023-10-10

申请号：US17881441

申请日：2022-08-04

Applicant: Scipher Medicine Corporation

Inventor： Susan Ghiassian ,  Theodore R. Mellors ,  Marc Santolini ,  Asher Ameli ,  Nancy Schoenbrunner ,  Viatcheslav R. Akmaev ,  Keith J. Johnson

IPC: A61P37/06 ,  C07K16/24 ,  G16B20/20 ,  G16H10/60 ,  G16H50/70 ,  G16H50/20 ,  G16H20/10 ,  A61P19/02 ,  G16B40/00 ,  A61K38/17

CPC classification number: G16B20/20 ,  A61K38/1793 ,  A61P19/02 ,  A61P37/06 ,  C07K16/241 ,  G16B40/00 ,  G16H10/60 ,  G16H20/10 ,  G16H50/20 ,  G16H50/70 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/76

Abstract: Presented herein are systems and methods for developing classifiers useful for predicting response to particular treatments. For example, in some embodiments, the present disclosure provides a method of treating subjects suffering from an autoimmune disorder, the method comprising administering an alternative to anti-TNF therapy to subjects who have been determined to be non-responsive via a classifier established to distinguish between responsive and non-responsive prior subjects in a cohort who have received the anti-TNF therapy.

公开(公告)号：US11198727B2

公开(公告)日：2021-12-14

申请号：US16394046

申请日：2019-04-25

Applicant: Scipher Medicine Corporation

Inventor： Keith J. Johnson ,  Susan Dina Ghiassian

IPC: C07K16/24 ,  G16H50/30 ,  A61P19/02 ,  G16B40/30 ,  G16B45/00 ,  C12Q1/6883 ,  C12Q1/6827 ,  G16B20/20 ,  C12Q1/6851

Abstract: Methods and systems for administering anti-TNF therapy to subjects who have been determined to display a gene expression response signature established to distinguish between responsive and non-responsive prior subjects who have received the anti-TNF therapy.