公开(公告)号：US08003097B2

公开(公告)日：2011-08-23

申请号：US12181238

申请日：2008-07-28

Applicant: Sally Schroeter ,  Kate Dora Games ,  Wagner Zago

Inventor： Sally Schroeter ,  Kate Dora Games ,  Wagner Zago

IPC: A61K39/395

CPC classification number: C07K16/18 ,  A01K2267/0312 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/70

Abstract: The invention provides improved agents and methods for treatment of cerebral amyloid angiopathy (CAA) and methods to effect prophylaxis of CAA. The methods can treat CAA concurrently with Alzheimer's disease or separately. The methods can effect prophylaxis of CAA concurrently with Alzheimer's disease or separately. The methods involve administering antibody that is specific for the N-terminus of Aβ or an agent that can induce such an antibody.

Abstract translation: 本发明提供了治疗脑淀粉样血管病（CAA）的改进剂和方法以及预防CAA的方法。 该方法可以同时治疗阿尔茨海默病或分离。 该方法可以与阿尔茨海默病同时预防CAA或分开。 所述方法包括给予A＆Bgr的N末端特异性的抗体; 或可以诱导这种抗体的药剂。

公开(公告)号：US20120282248A1

公开(公告)日：2012-11-08

申请号：US13076379

申请日：2011-03-30

Applicant: Sally Schroeter ,  Kate Dora Games ,  Wagner Zago

Inventor： Sally Schroeter ,  Kate Dora Games ,  Wagner Zago

IPC: A61K39/395 ,  A61P25/28

CPC classification number: C07K16/18 ,  A01K2267/0312 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/70

Abstract: The invention provides improved agents and methods for treatment of cerebral amyloid angiopathy (CAA) and methods to effect prophylaxis of CAA. The methods can treat CAA concurrently with Alzheimer's disease or separately. The methods can effect prophylaxis of CAA concurrently with Alzheimer's disease or separately. The methods involve administering antibody that is specific for the N-terminus of Aβ or an agent that can induce such an antibody.

Abstract translation: 本发明提供了治疗脑淀粉样血管病（CAA）的改进剂和方法以及预防CAA的方法。 该方法可以同时治疗阿尔茨海默病或分离。 该方法可以与阿尔茨海默病同时预防CAA或分开。 所述方法包括给予A＆Bgr的N末端特异性的抗体; 或可以诱导这种抗体的药剂。

公开(公告)号：US20090142270A1

公开(公告)日：2009-06-04

申请号：US12181238

申请日：2008-07-28

Applicant: Sally Schroeter ,  Kate Dora Games ,  Wagner Zago

Inventor： Sally Schroeter ,  Kate Dora Games ,  Wagner Zago

IPC: A61K49/00 ,  A61K39/395 ,  A61P25/28

CPC classification number: C07K16/18 ,  A01K2267/0312 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/70

Abstract: The invention provides improved agents and methods for treatment of cerebral amyloid angiopathy (CAA) and methods to effect prophylaxis of CAA. The methods can treat CAA concurrently with Alzheimer's disease or separately. The methods can effect prophylaxis of CAA concurrently with Alzheimer's disease or separately. The methods involve administering antibody that is specific for the N-terminus of Aβ or an agent that can induce such an antibody.

Abstract translation: 本发明提供了治疗脑淀粉样血管病（CAA）的改进剂和方法以及预防CAA的方法。 该方法可以同时治疗阿尔茨海默病或分离。 该方法可以与阿尔茨海默病同时预防CAA或分开。 所述方法包括施用对Aβ的N末端特异的抗体或可诱导这种抗体的药剂。

公开(公告)号：US20080292625A1

公开(公告)日：2008-11-27

申请号：US12106206

申请日：2008-04-18

Applicant: Sally Schroeter ,  Kate Dora Games

Inventor： Sally Schroeter ,  Kate Dora Games

IPC: A61K39/395 ,  C07K16/18 ,  A61P25/28

CPC classification number: C07K16/18 ,  A61K2039/505

Abstract: The invention provides improved agents and methods for treatment of cerebral amyloid angiopathy (CAA) and methods to effect prophylaxis of CAA. The methods can treat CAA concurrently with Alzheimer's disease or separately. The methods can effect prophylaxis of CAA concurrently with Alzheimer's disease or separately. The methods involve administering antibody that is specific for the N-terminus of Aβ or an agent that can induce such an antibody.

Abstract translation: 本发明提供了治疗脑淀粉样血管病（CAA）的改进剂和方法以及预防CAA的方法。 该方法可以同时治疗阿尔茨海默病或分离。 该方法可以与阿尔茨海默病同时预防CAA或分开。 所述方法包括施用对Aβ的N末端特异的抗体或可诱导这种抗体的药剂。