公开(公告)号：US12178884B2

公开(公告)日：2024-12-31

申请号：US16993009

申请日：2020-08-13

Applicant: SNIPR Technologies Limited

Inventor： Jasper Clube

IPC: C12N15/79 ,  A61K35/74 ,  A61K48/00 ,  A61P31/04 ,  C12N9/22 ,  C12N15/63 ,  C12N15/90 ,  C12P19/34 ,  C12N15/70 ,  C12N15/74

Abstract: The invention relates to retrieving or modifying target nucleic acids, such as host cell chromosomal DNA, by homologous recombination with vectors that have been cut to provide recombinogenic nucleic acid strands in situ. The methods described herein can be used to modify a target nucleic acid in vitro or in any prokaryotic or eukaryotic cell using homologous recombination.

公开(公告)号：US11612617B2

公开(公告)日：2023-03-28

申请号：US15817144

申请日：2017-11-17

Applicant: SNIPR TECHNOLOGIES LIMITED

Inventor： Jasper Clube

IPC: A61K35/74 ,  C12N15/90 ,  C12N9/22 ,  A61K31/7105 ,  C12N15/113 ,  C12N15/74 ,  C12N15/70 ,  A61K31/711 ,  A61K45/06 ,  C12N15/10 ,  C12N9/16 ,  A01N63/50 ,  A01N63/60 ,  A01N63/00 ,  A61K48/00 ,  C12N1/20 ,  C12N7/00 ,  A61K35/00

Abstract: The invention relates to methods, uses, systems, arrays, engineered nucleotide sequences and vectors for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for treatment of microbes such as for environmental, medical, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system.

公开(公告)号：US11471531B2

公开(公告)日：2022-10-18

申请号：US17132624

申请日：2020-12-23

Applicant: SNIPR Technologies Limited

Inventor： Jasper Clube ,  Morten Sommer ,  Christian Grøndahl

IPC: A61K39/395 ,  A61K39/00 ,  A61P37/00 ,  A61P35/00 ,  A61K31/7105 ,  A61K35/15 ,  A61K35/17

Abstract: The invention relates to methods of modulating immune cells in a patient by altering microbiota of the patient. The invention also relates to methods of modulating treatments or therapies in a subject organism by altering microbiota of the subject. The invention also relates to cell populations, systems, arrays, cells, RNA, kits and other means for effecting this. In an example, advantageously selective targeting of a particular species in a human gut microbiota using guided nucleic acid modification is carried out to effect the alteration.

公开(公告)号：US11351252B2

公开(公告)日：2022-06-07

申请号：US16453598

申请日：2019-06-26

Applicant: SNIPR Technologies Limited

Inventor： Jasper Clube

IPC: A61K39/00 ,  A61K39/395 ,  A61K35/15 ,  A61K35/17 ,  A61K31/7105 ,  A61P37/00 ,  A61P35/00

Abstract: The invention relates to methods of modulating immune cells in a patient by altering microbiota of the patient. The invention also relates to methods of modulating treatments or therapies in a subject organism by altering microbiota of the subject. The invention also relates to cell populations, systems, arrays, cells, RNA, kits and other means for effecting this. In an example, advantageously selective targeting of a particular species in a human gut microbiota using guided nucleic acid modification is carried out to effect the alteration.

公开(公告)号：US20210386773A1

公开(公告)日：2021-12-16

申请号：US17331413

申请日：2021-05-26

Applicant: SNIPR Technologies Limited

Inventor： Jasper CLUBE

IPC: A61K31/7105 ,  C12N15/113 ,  C12N15/74 ,  C12N15/70 ,  A61K31/711 ,  A61K45/06 ,  C12N15/10 ,  C12N9/16 ,  A61K35/74 ,  C12N15/90 ,  A01N63/50 ,  A01N63/60 ,  A01N63/00 ,  A61K48/00 ,  C12N1/20 ,  C12N7/00

Abstract: The invention relates to methods, uses, systems, arrays, engineered nucleotide sequences and vectors for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for treatment of microbes such as for environmental, medical, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system.

公开(公告)号：US11141481B2

公开(公告)日：2021-10-12

申请号：US17005121

申请日：2020-08-27

Applicant: SNIPR Technologies Limited

Inventor： Jasper Clube

IPC: A61K39/395 ,  A61K39/00 ,  A61P37/00 ,  A61P35/00 ,  A61K31/7105 ,  A61K35/15 ,  A61K35/17

Abstract: The invention relates to methods of modulating immune cells in a patient by altering microbiota of the patient. The invention also relates to methods of modulating treatments or therapies in a subject organism by altering microbiota of the subject. The invention also relates to cell populations, systems, arrays, cells, RNA, kits and other means for effecting this. In an example, advantageously selective targeting of a particular species in a human gut microbiota using guided nucleic acid modification is carried out to effect the alteration.

公开(公告)号：US20200205416A1

公开(公告)日：2020-07-02

申请号：US16818962

申请日：2020-03-13

Applicant: SNIPR Technologies Limited

Inventor： Jasper CLUBE

IPC: A01N63/00 ,  C12N15/113 ,  C12N15/74 ,  C12N15/70 ,  A61K31/711 ,  A61K45/06 ,  A61K31/7105 ,  C12N15/10 ,  C12N9/16 ,  A61K48/00 ,  C12N1/20 ,  C12N7/00

Abstract: The invention relates to methods, uses, systems, arrays, engineered nucleotide sequences and vectors for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for treatment of microbes such as for environmental, medical, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system.

公开(公告)号：US10596255B2

公开(公告)日：2020-03-24

申请号：US16389376

申请日：2019-04-19

Applicant: SNIPR Technologies Limited

Inventor： Jasper Clube

IPC: A61K39/00 ,  A61K39/38 ,  A61K39/02 ,  A61K39/09 ,  A61K39/085 ,  A61K39/10 ,  A61K39/08 ,  A61K39/102 ,  A61K39/118 ,  A61K39/395 ,  A61K35/15 ,  A61K35/17 ,  A61K31/7105 ,  A61P37/00 ,  A61P35/00

Abstract: The invention relates to methods of modulating immune cells in a patient by altering microbiota of the patient. The invention also relates to methods of modulating treatments or therapies in a subject organism by altering microbiota of the subject. The invention also relates to cell populations, systems, arrays, cells, RNA, kits and other means for effecting this. In an example, advantageously selective targeting of a particular species in a human gut microbiota using guided nucleic acid modification is carried out to effect the alteration.

公开(公告)号：US10506812B2

公开(公告)日：2019-12-17

申请号：US15817125

申请日：2017-11-17

Applicant: SNIPR TECHNOLOGIES LIMITED

Inventor： Jasper Clube

IPC: A01N63/00 ,  C12N15/113 ,  C12N15/74 ,  C12N15/70 ,  A61K31/711 ,  A61K45/06 ,  A61K31/7105 ,  C12N15/10 ,  C12N9/16 ,  A61K48/00 ,  C12N1/20 ,  C12N7/00

Abstract: The invention relates to methods, uses, systems, arrays, engineered nucleotide sequences and vectors for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for treatment of microbes such as for environmental, medical, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system.

公开(公告)号：US20190321470A1

公开(公告)日：2019-10-24

申请号：US16453609

申请日：2019-06-26

Applicant: SNIPR Technologies Limited

Inventor： Jasper CLUBE

IPC: A61K39/395 ,  A61P35/00 ,  A61K39/00 ,  A61K35/15 ,  A61K31/7105 ,  A61P37/00 ,  A61K35/17

Abstract: The invention relates to methods of modulating immune cells in a patient by altering microbiota of the patient. The invention also relates to methods of modulating treatments or therapies in a subject organism by altering microbiota of the subject. The invention also relates to cell populations, systems, arrays, cells, RNA, kits and other means for effecting this. In an example, advantageously selective targeting of a particular species in a human gut microbiota using guided nucleic acid modification is carried out to effect the alteration.