公开(公告)号：US11781980B2

公开(公告)日：2023-10-10

申请号：US16754009

申请日：2018-10-05

Applicant: SIME DIAGNOSTICS LTD.

Inventor： Peter Schousboe ,  Henrik Verder

IPC: G01N33/92 ,  G01N21/3577 ,  G01N1/40 ,  G01N33/487

CPC classification number: G01N21/3577 ,  G01N1/4077 ,  G01N33/487 ,  G01N33/92 ,  G01N2001/4083 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2800/12

Abstract: The present invention relates to methods for diagnosing Respiratory Distress Syndrome of newborn.

公开(公告)号：US20160103143A1

公开(公告)日：2016-04-14

申请号：US14893822

申请日：2014-05-27

Applicant: SIME DIAGNOSTICS LTD.

Inventor： Henrik Verder ,  Agnar Höskuldsson

IPC: G01N33/92 ,  A61M16/04 ,  G01N21/35

CPC classification number: G01N33/92 ,  A61M16/04 ,  G01N21/35 ,  G01N2800/125

Abstract: The present invention concerns methods and tools for analysing biomarkers useful for diagnosing an individual, in particular a newborn, with a respiratory disease, especially a newborn suffering from respiratory distress syndrome (RDS). The method and tools of the invention can in one embodiment be used for very rapidly detecting the ratio between lecithin and sphingomyelin in very small body fluid samples, e.g. gastric aspirate of a newborn. The invention is thus useful for obtaining a rapid treatment of RDS by administration of surfactant.

Abstract translation: 本发明涉及用于分析用于诊断具有呼吸系统疾病，特别是患有呼吸窘迫综合征（RDS）的新生儿的个体，特别是新生儿的生物标志物的方法和工具。 在一个实施方案中，本发明的方法和工具可用于非常快速地检测非常小的体液样品中卵磷脂和鞘磷脂之间的比例，例如， 新生儿胃抽吸物。 因此，本发明可用于通过施用表面活性剂快速处理RDS。

公开(公告)号：US20230160818A1

公开(公告)日：2023-05-25

申请号：US17906800

申请日：2021-03-26

Applicant: Sime Diagnostics Ltd.

Inventor： Henrik Verder

IPC: G01N21/3577 ,  G06N20/10 ,  G01N33/50

CPC classification number: G01N21/3577 ,  G06N20/10 ,  G01N33/50 ,  G01N2021/3595

Abstract: The present disclosure relates to a computer-implemented method for predicting a risk of an infant developing bronchopulmonary dysplasia (BPD), the method comprising the steps of: obtaining a dataset, of the infant, comprising a. clinical data; b. lung maturity data; and c. gastric aspirate (GAS) data; analysing said dataset, thereby obtaining an analysed data result; and based on said analysed data result predicting the risk of the infant developing BPD.

公开(公告)号：US20230223150A1

公开(公告)日：2023-07-13

申请号：US17999985

申请日：2021-06-04

Applicant: Sime Diagnostics Ltd.

Inventor： Peter Schousboe ,  Henrik Verder ,  Povl Verder

IPC: G16H50/30 ,  G01N33/92 ,  G01N21/3577 ,  A61K31/685

CPC classification number: G16H50/30 ,  G01N33/92 ,  G01N21/3577 ,  A61K31/685 ,  G01N2021/3595

Abstract: The present invention relates to methods and systems for predicting the likelihood of acute respiratory distress syndrome (ARDS) in adult subjects. The invention further relates to methods of treatment and identification of subjects with an increased likelihood of developing ARDS as determined by the disclosed methods.

公开(公告)号：US11105822B2

公开(公告)日：2021-08-31

申请号：US14893822

申请日：2014-05-27

Applicant: Sime Diagnostics Ltd.

Inventor： Henrik Verder ,  Agnar Höskuldsson

IPC: G01N33/92 ,  G01N21/35 ,  A61B5/00 ,  A61M16/04

Abstract: The present invention concerns methods and tools for analysing biomarkers useful for diagnosing an individual, in particular a newborn, with a respiratory disease, especially a newborn suffering from respiratory distress syndrome (RDS). The method and tools of the invention can in one embodiment be used for very rapidly detecting the ratio between lecithin and sphingomyelin in very small body fluid samples, e.g. gastric aspirate of a newborn. The invention is thus useful for obtaining a rapid treatment of RDS by administration of surfactant.

公开(公告)号：US20200326354A1

公开(公告)日：2020-10-15

申请号：US16754019

申请日：2018-10-05

Applicant: SIME DIAGNOSTICS LTD.

Inventor： Peter SCHOUSBOE ,  Henrik VERDER

IPC: G01N33/92 ,  G01N1/28 ,  G01N1/38 ,  G01N33/68 ,  G01N21/3577 ,  H01J49/26

Abstract: The present invention relates to methods for diagnosing diseases and disorders by measuring the amounts of one or more compounds in lamellar bodies isolated from a sample derived from a subject suspected of suffering from a disorder. Also disclosed are methods for monitoring efficacy of a treatment, methods for monitoring disease progression in a subject, as well as computer-implemented methods for diagnosis and systems for performing said methods.