公开(公告)号：US20050106152A1

公开(公告)日：2005-05-19

申请号：US10500216

申请日：2002-12-26

申请人： Yuichi Hikichi ,  Ryosuke Katsuyama ,  Yuichi Kakoi

发明人： Yuichi Hikichi ,  Ryosuke Katsuyama ,  Yuichi Kakoi

IPC分类号： A61K31/7088 ,  A61K48/00 ,  A61P35/00 ,  C07K14/47 ,  G01N33/574 ,  C12Q1/68 ,  A61K39/395

CPC分类号： G01N33/57407 ,  A61K31/7088 ,  A61K48/00 ,  C07K14/47

摘要： A compound or its salt that regulates the activities of a protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, an antisense nucleotide containing a base sequence or a part thereof which is complementary or substantially complementary io the base sequence of a DNA encoding a protein or its partial peptide having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, etc. can be used as preventive/therapeutic agents for cancer, etc.

摘要翻译： 调节具有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质的活性的化合物或其盐，其含有碱基序列或其部分的反义核苷酸或其部分互补或 基本上互补的编码具有与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列的蛋白质或其部分肽的DNA的碱基序列可用作预防/治疗剂 癌症等

公开(公告)号：US20110300068A1

公开(公告)日：2011-12-08

申请号：US13138146

申请日：2010-01-12

申请人： Tatsuya Watanabe ,  Shinichi Kondo ,  Ryosuke Katsuyama

发明人： Tatsuya Watanabe ,  Shinichi Kondo ,  Ryosuke Katsuyama

IPC分类号： A61K51/10 ,  A61P35/00 ,  G01N33/574 ,  A61K49/00 ,  C07K16/22 ,  A61K39/395

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76

摘要： The present invention provides an agent for the prophylaxis or treatment of kidney cancer or urinary bladder cancer, and a diagnostic reagent for these cancers which comprise an antibody against nerve growth factor 2/neurotrophin-3 or a partial peptide thereof or a salt thereof, which antibody neutralizes nerve growth factor 2/neurotrophin-3 and does not cross-react with the Nerve Growth Factor.

摘要翻译： 本发明提供了预防或治疗肾癌或膀胱癌的药剂，以及这些癌症的诊断试剂，其包含抗神经生长因子2 /神经营养因子-3或其部分肽或其盐的抗体，其中 抗体中和神经生长因子2 /神经营养因子-3，并且不与神经生长因子交叉反应。

公开(公告)号：US20100086911A1

公开(公告)日：2010-04-08

申请号：US11885447

申请日：2006-03-02

申请人： Ryosuke Katsuyama ,  Shinichi Kondo

发明人： Ryosuke Katsuyama ,  Shinichi Kondo

IPC分类号： C12Q1/68 ,  C07K16/00 ,  C07H21/00 ,  C12N5/00 ,  C12Q1/02 ,  G01N33/53 ,  C07K14/00

CPC分类号： G01N33/57407 ,  G01N33/5011 ,  G01N33/57415 ,  G01N2510/00

摘要： Identification of a novel target molecule for preventing/treating cancer and a preventive/remedy agent for cancer which targets the molecule, specifically, an agent for promoting the apoptosis in cancer cells and/or inhibiting the growth of cancer cells and a preventive/remedy agent for cancer, which comprise an antibody against a protein including the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, or SEQ ID NO: 10; an antisense polynucleotide of the protein (preferably, siRNA against mRNA of the protein); and a substance controlling the expression and/or activity of the protein, are provided by the present invention. A method of screening for a substance that promotes apoptosis in cancer cells and/or inhibits the growth of cancer cells and a preventive/remedy substance for cancer, in which the method comprises using a protein (preferably a cell producing the protein), an antibody against the protein, or a polynucleotide encoding the protein, is also provided by the present invention.

摘要翻译： 用于预防/治疗癌症的新型靶分子的鉴定和靶向分子的癌症的预防/补救剂，特别是用于促进癌细胞凋亡和/或抑制癌细胞生长的药剂和预防/补救剂 包括与包含与SEQ ID NO：2，SEQ ID NO：4，SEQ ID NO：6，SEQ ID NO：8所示的氨基酸序列相同或基本上相同的氨基酸序列的蛋白质的抗体 ，或SEQ ID NO：10; 蛋白质的反义多核苷酸（优选地，针对蛋白质的mRNA的siRNA）; 和控制蛋白质的表达和/或活性的物质由本发明提供。 一种筛选促进癌细胞凋亡和/或抑制癌细胞生长的物质和癌症预防/治疗物质的方法，其中该方法包括使用蛋白质（优选产生该蛋白质的细胞），抗体 本发明还提供了针对蛋白质或编码该蛋白质的多核苷酸。