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1.发明授权Methods and reagents for identifying/isolating T regulatory (Treg) cells and for treating individuals 有权用于鉴定/分离T调节（Treg）细胞和用于治疗个体的方法和试剂公开(公告)号：US08815526B2
公开(公告)日：2014-08-26
申请号：US11910442
申请日：2006-03-31
CPC分类号： C07K14/47 , A61K49/0004 , G01N33/564 , G01N33/56972 , G01N2800/205
摘要： An affinity ligand is reactive to the GARP protein may be capable of binding to an extracellular domain of GARP protein expressed on regulatory T (Treg) cells. The affinity ligand may be an antibody and may be used to identify Treg cells. A method comprises providing a blood sample from a subject and determining the amount of Treg cells in that sample. A composition containing Treg cells may be administered to an individual to suppress effector T cell activity in the individual. A composition containing an affinity ligand capable of binding to a GARP domain may be administered to an individual to suppress Treg cell activity and increase effector T cell activity in the individual. A kit for detecting Treg cells may include an affinity ligand reactive with mammalian GARP protein.
摘要翻译： 亲和配体对GARP蛋白具有反应性，可能能够结合在调节性T（Treg）细胞上表达的GARP蛋白的细胞外结构域。 亲和配体可以是抗体，可用于鉴定Treg细胞。 一种方法包括提供来自受试者的血液样品并确定该样品中的Treg细胞的量。 可以向个体施用含有Treg细胞的组合物以抑制个体中的效应T细胞活性。 可以向个体施用含有能够结合GARP结构域的亲和配体的组合物，以抑制个体的Treg细胞活性并增加效应T细胞的活性。 用于检测Treg细胞的试剂盒可以包括与哺乳动物GARP蛋白反应的亲和配体。
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2.发明申请Methods and Reagents for Identifying/Isolating T Regulatory (Treg) Cells and for Treating Individuals 有权用于鉴定/分离T调节（Treg）细胞和治疗个体的方法和试剂公开(公告)号：US20080279834A1
公开(公告)日：2008-11-13
申请号：US11910442
申请日：2006-03-31
CPC分类号： C07K14/47 , A61K49/0004 , G01N33/564 , G01N33/56972 , G01N2800/205
摘要： An affinity ligand is reactive to the GARP protein may be capable of binding to an extracellular domain of GARP protein expressed on regulatory T (Treg) cells. The affinity ligand may be an antibody and may be used to identify Treg cells. A method comprises providing a blood sample from a subject and determining the amount of Treg cells in that sample. A composition containing Treg cells may be administered to an individual to suppress effector T cell activity in the individual. A composition containing an affinity ligand capable of binding to a GARP domain may be administered to an individual to suppress Treg cell activity and increase effector T cell activity in the individual. A kit for detecting Treg cells may include an affinity ligand reactive with mammalian GARP protein.
摘要翻译： 亲和配体对GARP蛋白具有反应性，可能能够结合在调节性T（Treg）细胞上表达的GARP蛋白的细胞外结构域。 亲和配体可以是抗体，可用于鉴定Treg细胞。 一种方法包括提供来自受试者的血液样品并确定该样品中的Treg细胞的量。 可以向个体施用含有Treg细胞的组合物以抑制个体中的效应T细胞活性。 可以向个体施用含有能够结合GARP结构域的亲和配体的组合物，以抑制个体中的Treg细胞活性并增加效应T细胞的活性。 用于检测Treg细胞的试剂盒可以包括与哺乳动物GARP蛋白反应的亲和配体。
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