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公开(公告)号：US4916204A
公开(公告)日：1990-04-10
申请号：US80332
申请日：1987-07-31
申请人： Abraham J. Domb , Robert S. Langer , Eyal Ron , Steven Giannos , Rohit Kothari , Edith Mathiowitz
发明人： Abraham J. Domb , Robert S. Langer , Eyal Ron , Steven Giannos , Rohit Kothari , Edith Mathiowitz
IPC分类号： A61K31/335 , A61K31/365 , A61K31/39 , C08G67/04 , C08G69/08 , C08G69/10
CPC分类号： A61K31/335 , A61K31/365 , A61K31/39 , C08G67/04 , C08G69/08 , C08G69/10 , Y10S514/863
摘要： A method for synthesizing polyanhydrides in solution using coupling agents and a removable acid acceptor to effect a one-step polymerization of dicarboxylic acids. As used in the method, these coupling agents include phosgene, diphosgene, and acid chlorides. Insoluble acid acceptors include insoluble polyamines and crosslinked polyamines such as polyethyleneimine and polyvinylpyridine and inorganic bases such as K.sub.2 CO.sub.3, Na.sub.2 CO.sub.3, NaHCO.sub.3, and CaCO.sub.3. The only byproduct formed is a removable hydrochloric acid-acid acceptor.Examples are provided of the polymerization of highly pure polyanhydrides using phosgene, diphosgene or an acid chloride as the coupling agent, in combination with either an insoluble acid acceptor or a soluble acid acceptor in a solvent wherein the polymerization byproduct or polymer is insoluble.A particularly important application of these polyanhydrides is in the formation of drug delivery devices containing bioactive compounds. The method is also useful in the polymerization of dicarboxylic acids including heat liable dipeptides of glutamic or aspartic acid.
摘要翻译： 使用偶联剂和可除去的酸受体在溶液中合成聚酐以进行二羧酸的一步聚合的方法。 如该方法所用，这些偶联剂包括光气，双光气和酰氯。 不溶性酸受体包括不溶性多胺和交联聚胺如聚乙烯亚胺和聚乙烯吡啶以及无机碱如K 2 CO 3，Na 2 CO 3，NaHCO 3和CaCO 3。 形成的唯一副产物是可除去的盐酸酸受体。 提供了使用光气，双极光或酰氯作为偶联剂的高纯度聚酐与在溶剂中的不溶性酸受体或可溶性酸受体组合的聚合反应，其中聚合副产物或聚合物是不溶的。 这些多酸酐的特别重要的应用是形成含有生物活性化合物的药物递送装置。 该方法也可用于二羧酸的聚合，包括谷氨酸或天冬氨酸的热应答二肽。
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公开(公告)号：US08611889B2
公开(公告)日：2013-12-17
申请号：US11535283
申请日：2006-09-26
申请人： Sudheer Kumar Peddireddy , Vani Budhati , Guoxin Fan , Sundararajan Chellappan , Rohit Kothari , Gary Bernitz
发明人： Sudheer Kumar Peddireddy , Vani Budhati , Guoxin Fan , Sundararajan Chellappan , Rohit Kothari , Gary Bernitz
摘要： A system for remote handset diagnostics is provided. The system includes a plurality of handsets each having a diagnostic engine, and a carrier system having a plurality of encoder/decoder components. Each encoder/decoder component is operable to promote communication with at least one diagnostic engine to obtain diagnostic data. The carrier system further includes a diagnostic component that is operable to provide a common interface for diagnosing handsets. The diagnostic component is also operable to communicate with the plurality of encoder/decoder components and to facilitate diagnosis of the handset.
摘要翻译： 提供了一种用于远程手机诊断的系统。 该系统包括多个具有诊断引擎的手机，以及具有多个编码器/解码器部件的载体系统。 每个编码器/解码器组件可操作以促进与至少一个诊断引擎的通信以获得诊断数据。 载体系统还包括诊断部件，其可操作以提供用于诊断手机的公共接口。 诊断部件还可操作以与多个编码器/解码器部件通信并且便于诊断手机。
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公开(公告)号：US20080084993A1
公开(公告)日：2008-04-10
申请号：US11535293
申请日：2006-09-26
IPC分类号： H04M1/00
CPC分类号： H04M1/24 , H04M1/72527 , H04M1/7253 , H04W24/00
摘要： A system for handset self diagnostics is provided. The system includes a handset and a diagnostic engine on the handset to obtain diagnostic data for the handset. The system also includes an application on the handset, and the application includes at least one user interface that uses the diagnostic data to assist a user of the handset to operate the handset.
摘要翻译： 提供了一种手机自诊断系统。 该系统包括手持机上的手机和诊断引擎，以获取手机的诊断数据。 该系统还包括在手机上的应用，并且该应用包括至少一个用户界面，其使用诊断数据来辅助手机的用户操作手机。
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公开(公告)号：US4933431A
公开(公告)日：1990-06-12
申请号：US269448
申请日：1988-11-09
申请人： Abraham J. Domb , Robert S. Langer , Eyal Ron , Steven Giannos , Rohit Kothari , Edith Mathiowitz
发明人： Abraham J. Domb , Robert S. Langer , Eyal Ron , Steven Giannos , Rohit Kothari , Edith Mathiowitz
摘要： A method for synthetizing polyanhydrides in solution using coupling agents and a removable acid acceptor to effect a one-step polymerization of dicarboxylic acids. As used in the method, these coupling agents include phosgene, diphosgene, and acid chlorides. Insoluble acid acceptors include insoluble polyamines and crosslinked polyamines such as polyethyleneimine and polyvinylpyridine and inorganic bases such as K.sub.2 CO.sub.3, Na.sub.2 CO.sub.3, NaHCO.sub.3, and CaCO.sub.3. The only byproduct formed is a removable hydrochloric acid-acid acceptor.Examples are provided of the polymerization of highly pure polyanhydrides using phosgene, diphosgene or an acid chloride as the coupling agent, in combination with either an insoluble acid acceptor or a soluble acid acceptor in a solvent wherein the polymerizaiton byproduct or polymer is insoluble.A particularly important application of these polyanhydrides is in the formation of drug delivery devices containing bioactive compounds. The method is also useful in the polymerization of dicarboxylic acids including heat liable dipeptides of glutamic or aspartic acid.
摘要翻译： 使用偶联剂和可除去的酸受体在溶液中合成聚酐以实现二羧酸的一步聚合的方法。 如该方法所用，这些偶联剂包括光气，双光气和酰氯。 不溶性酸受体包括不溶性多胺和交联聚胺如聚乙烯亚胺和聚乙烯吡啶以及无机碱如K 2 CO 3，Na 2 CO 3，NaHCO 3和CaCO 3。 形成的唯一副产物是可除去的盐酸酸受体。 提供了使用光气，双光气或酰氯作为偶联剂的高纯度聚酐与在溶剂中的不溶性酸受体或可溶性酸受体组合的聚合反应，其中聚合物副产物或聚合物是不溶的。 这些多酸酐的特别重要的应用是形成含有生物活性化合物的药物递送装置。 该方法也可用于二羧酸的聚合，包括谷氨酸或天冬氨酸的热应答二肽。
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公开(公告)号：US08244237B2
公开(公告)日：2012-08-14
申请号：US11535293
申请日：2006-09-26
IPC分类号： H04W24/00
CPC分类号： H04M1/24 , H04M1/72527 , H04M1/7253 , H04W24/00
摘要： A system for handset self diagnostics is provided. The system includes a handset and a diagnostic engine on the handset to obtain diagnostic data for the handset. The system also includes an application on the handset, and the application includes at least one user interface that uses the diagnostic data to assist a user of the handset to operate the handset.
摘要翻译： 提供了一种手机自诊断系统。 该系统包括手持机上的手机和诊断引擎，以获取手机的诊断数据。 该系统还包括在手机上的应用，并且该应用包括至少一个用户界面，其使用诊断数据来辅助手机的用户操作手机。
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公开(公告)号：US20080084992A1
公开(公告)日：2008-04-10
申请号：US11535283
申请日：2006-09-26
申请人： Sudheer Kumar Peddireddy , Vani Budhati , Guoxin Fan , Sundararajan Chellappan , Rohit Kothari , Gary Bernitz
发明人： Sudheer Kumar Peddireddy , Vani Budhati , Guoxin Fan , Sundararajan Chellappan , Rohit Kothari , Gary Bernitz
IPC分类号： H04M1/00
摘要： A system for remote handset diagnostics is provided. The system includes a plurality of handsets each having a diagnostic engine, and a carrier system having a plurality of encoder/decoder components. Each encoder/decoder component is operable to promote communication with at least one diagnostic engine to obtain diagnostic data. The carrier system further includes a diagnostic component that is operable to provide a common interface for diagnosing handsets. The diagnostic component is also operable to communicate with the plurality of encoder/decoder components and to facilitate diagnosis of the handset.
摘要翻译： 提供了一种用于远程手机诊断的系统。 该系统包括多个具有诊断引擎的手机，以及具有多个编码器/解码器部件的载体系统。 每个编码器/解码器组件可操作以促进与至少一个诊断引擎的通信，以获得诊断数据。 载体系统还包括诊断部件，其可操作以提供用于诊断手机的公共接口。 诊断部件还可操作以与多个编码器/解码器部件通信并且便于诊断手机。
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