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公开(公告)号：US20120238014A1
公开(公告)日：2012-09-20
申请号：US13437989
申请日：2012-04-03
申请人： Roger Pedersen , Ludovic Vallier , Gabrielle Brons
发明人： Roger Pedersen , Ludovic Vallier , Gabrielle Brons
IPC分类号： C12N5/0735
CPC分类号： C12N5/0625 , C12N5/0606 , C12N2500/25 , C12N2501/115 , C12N2501/119 , C12N2501/16 , C12N2533/52
摘要： The invention relates to the isolation and propagation of pluripotent cells isolated from the mammalian late epiblast layer, termed Epiblast Stem Cells (EpiSCs). These cells are useful in a range of applications, including the generation of transgenic animal species.
摘要翻译： 本发明涉及从哺乳动物晚期上皮细胞层分离的多能细胞的分离和繁殖，称为Epiblast干细胞（EpiSCs）。 这些细胞在一系列应用中是有用的，包括产生转基因动物物种。
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公开(公告)号：US20100034785A1
公开(公告)日：2010-02-11
申请号：US12514178
申请日：2007-11-09
申请人： Roger Pedersen , Ludovic Vallier
发明人： Roger Pedersen , Ludovic Vallier
CPC分类号： C12N5/0606 , C12N5/0623 , C12N2500/25 , C12N2500/35 , C12N2500/36 , C12N2500/44 , C12N2500/84 , C12N2500/90 , C12N2500/98 , C12N2501/115 , C12N2501/155 , C12N2501/16 , C12N2533/52
摘要： This invention relates to the culture of pluripotent cells in a fully humanised chemically defined medium. Cells may be cultured over a prolonged period of time without losing their pluripotent status or may be controllably induced to differentiate into progenitor cells of the three primary germ layers by the addition of differentiation factors, for example differentiation factors which modulate one or more of the Activin/Nodal, FGF, Wnt or BMP signalling pathways.
摘要翻译： 本发明涉及完全人源化化学界定的培养基中多能细胞的培养。 细胞可以在较长时间内培养而不丧失其多能性状态，或者通过加入分化因子可被可控地诱导分化为三个原代胚层的祖细胞，例如调节一种或多种激活素 / Nodal，FGF，Wnt或BMP信号通路。
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公开(公告)号：US08497125B2
公开(公告)日：2013-07-30
申请号：US13437989
申请日：2012-04-03
申请人： Roger Pedersen , Ludovic Vallier , Gabrielle Brons
发明人： Roger Pedersen , Ludovic Vallier , Gabrielle Brons
CPC分类号： C12N5/0625 , C12N5/0606 , C12N2500/25 , C12N2501/115 , C12N2501/119 , C12N2501/16 , C12N2533/52
摘要： The invention relates to the isolation and propagation of pluripotent cells isolated from the mammalian late epiblast layer, termed Epiblast Stem Cells (EpiSCs). These cells are useful in a range of applications, including the generation of transgenic animal species.
摘要翻译： 本发明涉及从哺乳动物晚期上皮细胞层分离的多能细胞的分离和繁殖，称为Epiblast干细胞（EpiSCs）。 这些细胞在一系列应用中是有用的，包括产生转基因动物物种。
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4.发明申请PLURIPOTENT CELLS FROM THE MAMMALIAN LATE EPIBLAST LAYER 有权来自MAMMALIAN LATE EPIBLAST LAYER的PLUIPOTENT细胞公开(公告)号：US20100064380A1
公开(公告)日：2010-03-11
申请号：US12312395
申请日：2007-11-09
申请人： Roger Pedersen , Ludovic Vallier , Gabrielle Brons
发明人： Roger Pedersen , Ludovic Vallier , Gabrielle Brons
CPC分类号： C12N5/0625 , C12N5/0606 , C12N2500/25 , C12N2501/115 , C12N2501/119 , C12N2501/16 , C12N2533/52
摘要： This invention relates to the isolation and propagation of pluripotent cells isolated from the mammalian late epiblast layer, termed Epiblast Stem Cells' (EpiSCs). These cells are useful in a range of applications, including the generation of transgenic animal species.
摘要翻译： 本发明涉及从哺乳动物晚期上皮细胞层（称为Epiblast干细胞）（EpiSCs）分离的多能细胞的分离和繁殖。 这些细胞在一系列应用中是有用的，包括产生转基因动物物种。
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公开(公告)号：US20140127173A1
公开(公告)日：2014-05-08
申请号：US14126212
申请日：2012-06-13
IPC分类号： C12N5/077
CPC分类号： C12N5/0661 , C12N5/0662 , C12N5/0691 , C12N2501/115 , C12N2501/155 , C12N2506/03
摘要： This invention relates to the production of populations of Smooth Muscle Cells (SMCs) of specific embryonic lineages, such as neuroectodermal and mesodermal SMCs. Pluripotent stem cells are cultured in one or more lineage induction media to produce progenitor cells of a defined embryonic lineage, which are then cultured in an SMC induction medium to produce a population of SMCs of the embryonic lineage. Populations of SMCs of defined lineages may be useful, for example, in in accurately modelling vascular disease.
摘要翻译： 本发明涉及特定胚胎谱系如神经外胚层和中胚层SMC的平滑肌细胞（SMC）群体的产生。 多能干细胞在一个或多个谱系诱导培养基中培养以产生定义的胚胎谱系的祖细胞，然后将其在SMC诱导培养基中培养以产生胚胎谱系的SMC群体。 定义谱系的SMC的群体可能是有用的，例如在准确地建模血管疾病中。
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公开(公告)号：US08153423B2
公开(公告)日：2012-04-10
申请号：US12312395
申请日：2007-11-09
申请人： Roger Pedersen , Ludovic Vallier , Gabrielle Brons
发明人： Roger Pedersen , Ludovic Vallier , Gabrielle Brons
CPC分类号： C12N5/0625 , C12N5/0606 , C12N2500/25 , C12N2501/115 , C12N2501/119 , C12N2501/16 , C12N2533/52
摘要： This invention relates to the isolation and propagation of pluripotent cells isolated from the mammalian late epiblast layer, termed Epiblast Stem Cells' (EpiSCs). These cells are useful in a range of applications, including the generation of transgenic animal species.
摘要翻译： 本发明涉及从哺乳动物晚期上皮细胞层（称为Epiblast干细胞）（EpiSCs）分离的多能细胞的分离和繁殖。 这些细胞在一系列应用中是有用的，包括产生转基因动物物种。
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公开(公告)号：US09238795B2
公开(公告)日：2016-01-19
申请号：US14126212
申请日：2012-06-13
IPC分类号： C12N5/077 , C12N5/071 , C12N5/073 , C12N5/0775
CPC分类号： C12N5/0661 , C12N5/0662 , C12N5/0691 , C12N2501/115 , C12N2501/155 , C12N2506/03
摘要： This invention relates to the production of populations of Smooth Muscle Cells (SMCs) of specific embryonic lineages, such as neuroectodermal and mesodermal SMCs. Pluripotent stem cells are cultured in one or more lineage induction media to produce progenitor cells of a defined embryonic lineage, which are then cultured in an SMC induction medium to produce a population of SMCs of the embryonic lineage. Populations of SMCs of defined lineages may be useful, for example, in accurately modelling vascular disease.
摘要翻译： 本发明涉及特定胚胎谱系如神经外胚层和中胚层SMC的平滑肌细胞（SMC）群体的产生。 多能干细胞在一个或多个谱系诱导培养基中培养以产生定义的胚胎谱系的祖细胞，然后将其在SMC诱导培养基中培养以产生胚胎谱系的SMC群体。 定义谱系的SMC的群体可能是有用的，例如，准确地建模血管疾病。
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公开(公告)号：US08323971B2
公开(公告)日：2012-12-04
申请号：US12514178
申请日：2007-11-09
申请人： Roger Pedersen , Ludovic Vallier
发明人： Roger Pedersen , Ludovic Vallier
CPC分类号： C12N5/0606 , C12N5/0623 , C12N2500/25 , C12N2500/35 , C12N2500/36 , C12N2500/44 , C12N2500/84 , C12N2500/90 , C12N2500/98 , C12N2501/115 , C12N2501/155 , C12N2501/16 , C12N2533/52
摘要： This invention relates to the culture of pluripotent cells in a fully humanised chemically defined medium. Cells may be cultured over a prolonged period of time without losing their pluripotent status or may be controllably induced to differentiate into progenitor cells of the three primary germ layers by the addition of differentiation factors, for example differentiation factors which modulate one or more of the Activin/Nodal, FGF, Wnt or BMP signalling pathways.
摘要翻译： 本发明涉及完全人源化化学界定的培养基中多能细胞的培养。 细胞可以在较长时间内培养而不丧失其多能性状态，或者通过加入分化因子可被可控地诱导分化为三个原代胚层的祖细胞，例如调节一种或多种激活素 / Nodal，FGF，Wnt或BMP信号通路。
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