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公开(公告)号：US07897142B2
公开(公告)日：2011-03-01
申请号：US11570156
申请日：2005-06-15
CPC分类号： A61K49/0056 , A61K49/0032 , C07K5/0817 , C07K5/126 , C07K14/70546 , G01N33/533
摘要： The invention relates to new peptide-based compounds and their use in diagnostic optical imaging techniques. More specifically the invention relates to the use of such peptide-based compounds as targeting vectors that bind to receptors associated with angiogenesis. The compounds are labelled with at least one cyanine dye reporter and may be used as contrast agents in optical imaging in diagnosis of angiogenesis-related diseases.
摘要翻译： 本发明涉及新的基于肽的化合物及其在诊断光学成像技术中的应用。 更具体地，本发明涉及这种基于肽的化合物作为与血管发生相关的受体结合的靶向载体的用途。 该化合物用至少一种花青染料报告物进行标记，并可用作造影剂用于诊断血管发生相关疾病的光学成像。
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2.发明申请Fluorination Process of Anilide Derivatives and Benzothiazole Fluorinate Derivatives as in VIVO Imaging Agents 有权苯乙烯衍生物和苯并噻唑氟化物衍生物的氟化方法如VIVO成像剂公开(公告)号：US20100234611A1
公开(公告)日：2010-09-16
申请号：US12063470
申请日：2006-08-11
申请人： Anthony Eamon Storey , Clare Louise Jones , Denis Raymond Christophe Bouvet , Nicolas Lasbistes , Steven Michael Fairway , Lorenzo Williams , Alexander Mark Gibson , Robert James Nairne , Farhad Karimi , Bengt Langstrom
发明人： Anthony Eamon Storey , Clare Louise Jones , Denis Raymond Christophe Bouvet , Nicolas Lasbistes , Steven Michael Fairway , Lorenzo Williams , Alexander Mark Gibson , Robert James Nairne , Farhad Karimi , Bengt Langstrom
IPC分类号： C07D277/66 , G21C1/01
CPC分类号： A61K51/0453 , B01J19/24 , B01J2219/24 , C07D277/66 , Y02P20/55
摘要： The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, —(CH2CH2O)q—CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.
摘要翻译： 本发明涉及制备式（I）化合物的方法：R1选自C 1-6烷基，C 2-6烯基和C 2-6炔基; 其包括：（i）与氟化物，适当的[18 F]氟化物反应，相应的式（II）化合物：其中R 2选自氢，C 1-10烷基，C 1-10卤代烷基，C 6-14芳基，C 6-14芳烷基， （CH 2 CH 2 O）q -CH 3，其中q是1至10的整数; R1如式（I）化合物所定义; R3是离去基团。 还要求具有式（II）的某些新型前体和含有这些前体的放射性药物试剂盒。
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3.发明授权Fluorination process of anilide derivatives and benzothiazole fluorinate derivatives as in vivo imaging agents 有权苯胺衍生物和苯并噻唑氟化物衍生物作为体内显像剂的氟化方法公开(公告)号：US08410312B2
公开(公告)日：2013-04-02
申请号：US12063470
申请日：2006-08-11
申请人： Anthony Eamon Storey , Clare Louise Jones , Denis Raymond Christophe Bouvet , Nicolas Lasbistes , Steven Michael Fairway , Lorenzo Williams , Alexander Mark Gibson , Robert James Nairne , Farhad Karimi , Bengt Langstrom
发明人： Anthony Eamon Storey , Clare Louise Jones , Denis Raymond Christophe Bouvet , Nicolas Lasbistes , Steven Michael Fairway , Lorenzo Williams , Alexander Mark Gibson , Robert James Nairne , Farhad Karimi , Bengt Langstrom
IPC分类号： C07C211/46
CPC分类号： A61K51/0453 , B01J19/24 , B01J2219/24 , C07D277/66 , Y02P20/55
摘要： The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, —(CH2CH2O)q—CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.
摘要翻译： 本发明涉及制备式（I）化合物的方法：R1选自C 1-6烷基，C 2-6烯基和C 2-6炔基; 其包括：（i）与氟化物，适当的[18 F]氟化物反应，相应的式（II）化合物：其中R 2选自氢，C 1-10烷基，C 1-10卤代烷基，C 6-14芳基，C 6-14芳烷基， （CH 2 CH 2 O）q -CH 3，其中q是1至10的整数; R1如式（I）化合物所定义; R3是离去基团。 还要求具有式（II）的某些新型前体和含有这些前体的放射性药物试剂盒。
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公开(公告)号：US20080095715A1
公开(公告)日：2008-04-24
申请号：US11570156
申请日：2005-06-15
CPC分类号： A61K49/0056 , A61K49/0032 , C07K5/0817 , C07K5/126 , C07K14/70546 , G01N33/533
摘要： The invention relates to new peptide-based compounds and their use in diagnostic optical imaging techniques. More specifically the invention relates to the use of such peptide-based compounds as targeting vectors that bind to receptors associated with angiogenesis. The compounds are labelled with at least one cyanine dye reporter and may be used as contrast agents in optical imaging in diagnosis of angiogenesis-related diseases.
摘要翻译： 本发明涉及新的基于肽的化合物及其在诊断光学成像技术中的应用。 更具体地，本发明涉及这种基于肽的化合物作为与血管发生相关的受体结合的靶向载体的用途。 该化合物用至少一种花青染料报告物进行标记，并可用作造影剂用于诊断血管发生相关疾病的光学成像。
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