公开(公告)号：US20070260212A1

公开(公告)日：2007-11-08

申请号：US11628774

申请日：2005-06-08

申请人： Robert Coifman

发明人： Robert Coifman

IPC分类号： A61J1/06

CPC分类号： A61J1/06 ,  A61J1/20 ,  A61M15/00 ,  A61M2202/064 ,  B65D1/09

摘要： Ampules are provided for the packaging and storage of drugs intended for nebulizer administration for which physical and/or chemical shelf life stability requires that the drug be stored in other than the diluent in which it will be nebulized, and in a volume or physical state that does not allow accurate dispensing from ordinary ampules.

摘要翻译： 提供安瓿用于包装和储存用于喷雾器给药的药物，其物理和/或化学保质期稳定性要求将药物储存在除了其将被喷雾的稀释剂之外，并且在体积或物理状态下 不允许从普通安瓿精确分配。

公开(公告)号：US20060260606A1

公开(公告)日：2006-11-23

申请号：US11131964

申请日：2005-05-18

申请人： Robert Coifman

发明人： Robert Coifman

IPC分类号： A61M11/00

CPC分类号： A61K9/008 ,  A61M11/002 ,  A61M15/0086 ,  A61M15/0088 ,  A61M15/009 ,  A61M2210/0618

摘要： An inhalable formulation of amphotericin B and a hydrofluoroalkane propellant in for pressurized metered dose aerosol canisters is provided. Also provided are methods for administering amphotericin B to the upper or lower respiratory tract of a patient with this inhalable formulation and a pulsatile nasal administration device for delivery of medications packaged in a metered dose aerosol canister to the paranasal sinuses.

摘要翻译： 提供了一种用于加压计量剂量气溶胶罐的两性霉素B和一种氢氟烷烃推进剂的可吸入制剂。 还提供了用这种可吸入制剂向患者的上呼吸道或下呼吸道施用两性霉素B的方法和用于将包装在计量剂量气溶胶罐中的药物递送至鼻旁窦的脉动鼻给药装置。

公开(公告)号：US20060253045A1

公开(公告)日：2006-11-09

申请号：US11378058

申请日：2006-03-17

申请人： Robert Coifman

发明人： Robert Coifman

IPC分类号： A61B5/08

CPC分类号： A61B5/0871 ,  A61B5/411 ,  G06F19/00 ,  G06F19/3418

摘要： An enhanced electronic peak flow meter is provided that combines some of the enhanced electronic features found in other electronic peak flow meters with software for executing a stochastic process control and evaluating the digital respiratory data collected by the meter. The programmed stochastic process control is capable of selecting and calculating any one of a number of pulmonary function parameters including at least one statistical process control variable to determine a pulmonary threshold. Information systems linking doctor's offices and patient's meters are further provided to transmit warning data in cases where the pulmonary threshold is exceeded.

摘要翻译： 提供了一种增强的电子峰值流量计，将其他电子峰值流量计中发现的一些增强型电子功能与用于执行随机过程控制和评估由仪表收集的数字呼吸数据的软件相结合。 编程的随机过程控制能够选择和计算多个肺功能参数中的任何一个，包括至少一个统计过程控制变量以确定肺阈值。 进一步提供连接医生办公室和病人米的信息系统，以在超过肺阈值的情况下传送警告数据。

公开(公告)号：US20070156403A1

公开(公告)日：2007-07-05

申请号：US11510435

申请日：2006-08-25

申请人： Robert Coifman

发明人： Robert Coifman

IPC分类号： G10L15/04

CPC分类号： G10L15/08

摘要： The present invention involves an enhanced method for operating a speech recognition system in which sequential vocabularies are loaded for comparison to the input speech. Form each sequential vocabulary a subset of candidate vocabulary elements are selected for matching, the probability match scores of each of the selected candidate vocabulary elements is weighted by a weighting factor that is dependent on the particular vocabulary from which the vocabulary elements are selected. As each set of candidate vocabulary elements is selected from the next sequential vocabulary, the selected set is combined with the set of previously selected and weighted vocabulary elements, which is then further weighted according to the weighting criteria of the then active vocabulary. At the end of the sequential vocabulary selection grouping process, the final, sequentially weighted match scores for the candidate vocabulary elements are arranged and an appropriate match to the input speech is presented.

摘要翻译： 本发明涉及一种用于操作语音识别系统的增强方法，其中连续词汇被加载以与输入语音进行比较。 选择候选词汇单元的子集来形成每个连续词汇表，以便将所选择的候选词汇单元中的每一个的概率匹配分数加权，该加权因子取决于选择词汇单元的特定词汇表。 由于从下一个顺序词汇表中选择每组候选词汇单元，所选择的组合与先前选择和加权的词汇单元组合，然后根据当时活动词汇表的加权标准进一步加权。 在顺序词汇选择分组处理结束时，排列候选词汇单元的最终顺序加权匹配分数，并给出与输入语音的适当匹配。

公开(公告)号：US20060171897A1

公开(公告)日：2006-08-03

申请号：US11353591

申请日：2006-02-14

申请人： Robert Coifman

发明人： Robert Coifman

IPC分类号： A61L9/04

CPC分类号： A61K9/0078

摘要： Formulations, methods and devices for producing formulations and methods for nebulizer delivery of formulations of water-insoluble drugs and drugs requiring storage in aqueous or other water-miscible pharmaceutically unacceptable vehicles for stability are provided. Also provided are methods for minimizing wastage of drugs administered by nebulizer, and for the achievement of quantitative dosing with diluent from a mass marketed formulations, which because of the mass market is much less costly per dose than formulations manufactured specifically for much lower volume medical use.

摘要翻译： 提供了用于制备用于喷雾器递送水不溶性药物和药物的制剂，方法和装置，其需要在水或其它与水可混溶的药学上不可接受的载体中保存以获得稳定性。 还提供了用于最小化由喷雾器施用的药物的浪费的方法，以及用于从大量销售的制剂中实现与稀释剂定量给药的方法，其由于大量市场的剂量比专门为较低体积的医疗用途制备的制剂成本低得多 。

公开(公告)号：US20050133024A1

公开(公告)日：2005-06-23

申请号：US10997278

申请日：2004-11-24

申请人： Robert Coifman

发明人： Robert Coifman

IPC分类号： A61B20060101 ,  A61B5/087 ,  A61M11/00 ,  A61M15/00 ,  A61M16/00

CPC分类号： A61B5/087 ,  A61B5/4839 ,  A61M15/00 ,  A61M16/208 ,  A61M2016/0036 ,  A61M2016/0039 ,  A61M2016/0042 ,  A61M2202/064 ,  A61M2205/8206

摘要： New applications of unidirectional airflow sensing in devices which measure inspiratory airflow and bidirectional airflow are provided. Such devices can be used for administration of a medication via inhalation, in spirometers and in devices which measure and monitor respiratory ventilation.

摘要翻译： 提供了单向气流检测在测量吸气气流和双向气流的设备中的新应用。 这样的装置可以用于通过吸入，肺活量计和用于测量和监测呼吸通气的装置中的药物的给药。

公开(公告)号：US20070038449A1

公开(公告)日：2007-02-15

申请号：US11584904

申请日：2006-10-23

申请人： Robert Coifman

发明人： Robert Coifman

IPC分类号： G10L15/06

CPC分类号： G10L15/065

摘要： A virtual vocabulary database is provided for use with a with a particular user database as part of a speech recognition system. Vocabulary elements within the virtual database are imported from the user database and are tagged to include numerical data corresponding to the historical use of the vocabulary element within the user database. For each speech input, potential vocabulary element matches from the speech recognition system are provided to the virtual database software which creates virtual sub-vocabularies from the criteria according to predefined criteria templates. The software then applies vocabulary element weighting adjustments according to the virtual sub-vocabulary weightings and applies the adjustment to the default weighting provided by the speech recognition system. The modified weightings are returned with the associated vocabulary elements to the speech engine for selection of an appropriate match to the input speech.

摘要翻译： 虚拟词汇数据库被提供用于与特定用户数据库一起用作语音识别系统的一部分。 虚拟数据库中的词汇元素从用户数据库导入，并被标记为包括与用户数据库中词汇元素的历史使用相对应的数字数据。 对于每个语音输入，来自语音识别系统的潜在词汇元素匹配被提供给根据预定义的标准模板从标准创建虚拟子词汇的虚拟数据库软件。 然后，软件根据虚拟子词汇权重应用词汇单元加权调整，并将调整应用于由语音识别系统提供的默认加权。 所修改的权重与相关联的词汇元素返回到语音引擎以选择与输入语音的适当匹配。