公开(公告)号：US07968748B2

公开(公告)日：2011-06-28

申请号：US12278268

申请日：2007-02-01

申请人： Elio Napolitano ,  Rita Fiaschi ,  Chiara Bechini ,  Gabriella Brunetto

发明人： Elio Napolitano ,  Rita Fiaschi ,  Chiara Bechini ,  Gabriella Brunetto

IPC分类号： C07C237/06 ,  C07C211/10

CPC分类号： C07D207/06 ,  C07C211/27 ,  C07C211/53 ,  C07C215/08 ,  C07C233/83 ,  C07C237/04 ,  C07C237/06 ,  C07C311/19 ,  C07D207/09 ,  C07D207/16

摘要： A process for resolving a compound in racemic form comprising the following steps is described: a) reacting a compound in racemic form with a resolving agent, b) forming a diastereoisomeric complex of the resolving agent and an enantiomer of interest, c) separating the enantiomer of interest from the obtained diastereoisomer, wherein such a process is characterized in that said resolving agent is a compound of Formula (I). A diastereoisomeric complex between the resolving agent of Formula (I) and the enantiomer of interest is also described. The process according to the invention allows acid and basic racemic mixtures to be separated.

摘要翻译： 描述了一种拆分含外消旋形式的化合物的方法，包括以下步骤：a）使外消旋形式的化合物与拆分剂反应，b）形成拆分剂和目的对映异构体的非对映异构体复合物，c）分离对映异构体 所获得的非对映异构体感兴趣，其中这种方法的特征在于所述拆分剂是式（I）的化合物。 还描述了式（I）的拆分剂与目标对映异构体之间的非对映异构复合物。 根据本发明的方法允许酸和碱性外消旋混合物分离。

公开(公告)号：US20090292129A1

公开(公告)日：2009-11-26

申请号：US12278268

申请日：2007-02-01

申请人： Elio Napolitano ,  Rita Fiaschi ,  Chiara Bechini ,  Gabriella Brunetto

发明人： Elio Napolitano ,  Rita Fiaschi ,  Chiara Bechini ,  Gabriella Brunetto

IPC分类号： C07D207/16 ,  C07D207/09 ,  C07D307/24 ,  C07C255/41 ,  C07C61/35

CPC分类号： C07D207/06 ,  C07C211/27 ,  C07C211/53 ,  C07C215/08 ,  C07C233/83 ,  C07C237/04 ,  C07C237/06 ,  C07C311/19 ,  C07D207/09 ,  C07D207/16

摘要： A process for resolving a compound in racemic form comprising the following steps is described: a) reacting a compound in racemic form with a resolving agent, b) forming a diastereoisomeric complex of the resolving agent and an enantiomer of interest, c) separating the enantiomer of interest from the obtained diastereoisomer, wherein such a process is characterized in that said resolving agent is a compound of Formula (I). A diastereoisomeric complex between the resolving agent of Formula (I) and the enantiomer of interest is also described. The process according to the invention allows acid and basic racemic mixtures to be separated.

摘要翻译： 描述了一种拆分含外消旋形式的化合物的方法，包括以下步骤：a）使外消旋形式的化合物与拆分剂反应，b）形成拆分剂和目的对映异构体的非对映异构体复合物，c）分离对映异构体 所获得的非对映异构体感兴趣，其中这种方法的特征在于所述拆分剂是式（I）的化合物。 还描述了式（I）的拆分剂与目标对映异构体之间的非对映异构复合物。 根据本发明的方法允许酸和碱性外消旋混合物分离。