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53 条记录 (耗时 0.021 秒)

    Ipratropium bromide enantiomer with prolonged duration of effect
    5.
    发明授权
    Ipratropium bromide enantiomer with prolonged duration of effect 有权
    异丙托溴铵对映异构体具有延长的疗效

    公开(公告)号：US06299861B1

    公开(公告)日：2001-10-09

    申请号：US09369711

    申请日：1999-08-06

    申请人： Rolf Banholzer ,  Richard Reichl ,  Bernd Disse ,  Georg Speck

    发明人： Rolf Banholzer ,  Richard Reichl ,  Bernd Disse ,  Georg Speck

    IPC分类号： A61L904

    CPC分类号： C07D451/10

    摘要： On account of the surprisingly powerful and long-lasting effect thereof, the salts of the L-(−)-enantiomer of (endo, syn)-(−)-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(methylethyl)-8-azoniabicyclo [3,2,1]octane are suitable as active substances for drugs administered by inhalation for respiratory tract therapy.

    摘要翻译： 由于其令人惊讶的强大和持久的效果，（内，顺） - （ - ） - 3-（3-羟基-1-氧代-2-苯基丙氧基） - （ - -8-甲基-8-（甲基乙基）-8-氮杂双环[3,2,1]辛烷适用于通过吸入呼吸道治疗给药的药物的活性物质。

    Use of diazepinones for treating disorders of the microcirculation
    6.
    发明授权
    Use of diazepinones for treating disorders of the microcirculation 失效
    二氮嗪酮用于治疗微循环障碍的用途

    公开(公告)号：US5001122A

    公开(公告)日：1991-03-19

    申请号：US353262

    申请日：1989-05-17

    申请人： Wolfgang Eberlein ,  Volker Trach ,  Wolfhard Engel ,  Gerhard Mihm ,  Norbert Mayer ,  Henri Doods ,  Richard Reichl

    发明人： Wolfgang Eberlein ,  Volker Trach ,  Wolfhard Engel ,  Gerhard Mihm ,  Norbert Mayer ,  Henri Doods ,  Richard Reichl

    IPC分类号： C07D243/38 ,  A61K31/00 ,  A61K31/55 ,  A61P9/00 ,  A61P9/08 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

    CPC分类号： A61K31/55 ,  Y10S514/921

    摘要： A method for treating shock in a patient, which comprises administering to the patient a therapeutically effective amount of a diazepinone of the general formula: ##STR1## wherein A represents a 5,11-dihydro-6H-pyrido[2,3-b] [1,4] benzodiazepin-6-one group bound in the 11-position; a 5,10-dihydro-11H-dibenzo [b,e] [1,4] diazepin-11-one group bound in the 5-position; a 5,11-dihydro-10H-pyrido [3-2b] [1-4] benzodiazepin-10-one group bound in the 5-position; a 4,9-dihydro-10H-thieno [3,4-b] [1,5] benzodiazpin-10-one group bound in the 4-position, unsubstituted or substituted at the 1- or 3-position or both in the 1- and 3-position by an alkyl group having from 1 to 4 carbon atoms, or in the 3-positionby chlorine, fluorine or bromine; a 6-11-dihydro-5H-pyrido [2,3-b] [1,5] benzodiazepin-5-one group bound in the 11-position; or a 1-methyl-1,4,9,10-tetrahydropyrrolo-[3,2-b] [1,5] benzodiazepin-10-one group bound in the 4-position, unsubstituted or substituted at the 3-position by methyl or methyl or chlorine;R.sub.1 represents a hydrogen atom or an alkyl group having from 1 to 3 carbon atoms;R.sub.2 represents an alkyl group having from 1 to 3 carbon atoms; andn and m each represent an integer from 1 to 3.

    摘要翻译： 一种治疗患者休克的方法，其包括向患者施用治疗有效量的通式如下的二氮杂酮：其中A代表5,11-二氢-6H-吡啶并[2,3-b] 结合在11位的[1,4]苯并二氮杂- 5位结合的5,10-二氢-11H-二苯并[b，e] [1,4]二氮杂-11-酮基; 5位结合的5,11-二氢-10H-吡啶并[3-2b] [1-4]苯并二氮杂-10-酮基; 在4-位上结合的未取代或取代的4,9-二氢-10H-噻吩并[3,4-b] [1,5]苯并二氮杂基-10-酮基或在 通过具有1至4个碳原子的烷基或3-，3-位上的氯，氟或溴取代1-和3-位; 在11位结合的6-11-二氢-5H-吡啶并[2,3-b] [1,5]苯并二氮杂-5-基; 或在4-位上结合的1-甲基-1,4,9,10-四氢吡咯并[3,2-b] [1,5]苯并二氮杂-10-酮基，其未被取代或在3位被 甲基或甲基或氯; R1表示氢原子或具有1至3个碳原子的烷基; R2表示具有1至3个碳原子的烷基; n和m各自表示1〜3的整数。

    Anticholinergics, processes for preparing them and pharmaceutical composition containing them
    8.
    发明授权
    Anticholinergics, processes for preparing them and pharmaceutical composition containing them 有权
    抗胆碱能药，其制备方法和含有它们的药物组合物

    公开(公告)号：US07652138B2

    公开(公告)日：2010-01-26

    申请号：US10970240

    申请日：2004-10-21

    申请人： Helmut Meissner ,  Gerd Morschhaeuser ,  Michael Paul Pieper ,  Gerald Pohl ,  Richard Reichl ,  Georg Speck

    发明人： Helmut Meissner ,  Gerd Morschhaeuser ,  Michael Paul Pieper ,  Gerald Pohl ,  Richard Reichl ,  Georg Speck

    IPC分类号： C07D491/00 ,  C07D451/00

    CPC分类号： C07D451/10 ,  C07D451/14

    摘要： A compound of formula 1 wherein: A is a group selected from X− is an anion with a single negative charge; R1 and R2 are each independently a C1-C4-alkyl optionally substituted with hydroxy or halogen; and R3, R4, R5, R6, R7, and R8 are each independently hydrogen, C1-C4-alkyl, C1-C4-alkyloxy, hydroxy, CF3, CN, NO2, or halogen, with the proviso that at least one of the groups R3, R4, R5, R6, R7, and R8 is not hydrogen, processes for preparing these compounds, pharmaceutical compositions containing these compounds, and their use as pharmaceutical compositions.

    摘要翻译： 式1的化合物，其中：A是选自X - 是具有单个负电荷的阴离子; R 1和R 2各自独立地为任选被羟基或卤素取代的C 1 -C 4烷基; 并且R 3，R 4，R 5，R 6，R 7和R 8各自独立地为氢，C 1 -C 4 - 烷基，C 1 -C 4 - 烷氧基，羟基，CF 3，CN，NO 2或卤素，条件是至少一个 R 3，R 4，R 5，R 6，R 7和R 8不是氢，制备这些化合物的方法，含有这些化合物的药物组合物及其作为药物组合物的用途。

    Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
    10.
    发明授权
    Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions 有权
    呫吨羧酸盐，其制备方法及其作为药物组合物的用途

    公开(公告)号：US07405224B2

    公开(公告)日：2008-07-29

    申请号：US10342080

    申请日：2003-01-14

    申请人： Sabine Germeyer ,  Helmut Meissner ,  Gerd Morschhaeuser ,  Sabine Pestel ,  Michael P. Pieper ,  Gerald Pohl ,  Richard Reichl ,  Georg Speck

    发明人： Sabine Germeyer ,  Helmut Meissner ,  Gerd Morschhaeuser ,  Sabine Pestel ,  Michael P. Pieper ,  Gerald Pohl ,  Richard Reichl ,  Georg Speck

    IPC分类号： A61K31/44

    CPC分类号： C07D451/06 ,  C07D451/10

    摘要： Xanthenecarboxylates of formula 1 wherein: A is a group selected from X− is an anion with a single negative charge; R is hydroxy, methyl, hydroxymethyl, ethyl, —CF3, —CHF2, or fluorine; R1 and R2, which are identical or different, are each C1-C5-alkyl which is optionally substituted by C3-C6-cycloalkyl, hydroxy, or halogen, or R1 and R2 together denote a —C3-C5-alkylene-bridge; and R3, R4, R3′, and R4′, which are identical or different, are each hydrogen, —C1-C4-alkyl, —C4-alkyloxy, hydroxy, —CF3, —CHF2, —CN, —NO2, or halogen, or a physiologically acceptable salt thereof, processes for preparing, them and their use in pharmaceutical compositions.

    摘要翻译： 式1的呫吨羧酸盐其中：A是选自X - 的一个基团，是具有单个负电荷的阴离子; R是羟基，甲基，羟甲基，乙基，-CF 3，-CHF 2，或氟; R 1和R 2相同或不同，分别为C 1 -C 5 - 烷基，其中R 1和R 2各自为C 1 -C 5 - 任选被C 3 -C 6 - 环烷基，羟基或卤素取代，或R 1和R 2 - >一起表示-C 3 -C 5 - 亚烷基桥; 和R 3，R 4，R 3，R 3和R 4'相同或不同， 各自为氢，-C 1 -C 4 - 烷基，-C 4 - 烷氧基，羟基，-CF 3 - 或其生理学上可接受的盐，其制备方法，它们及其在药物组合物中的用途。