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    2-(2,4,5-substituted-anilino) pyrimidine compounds
    3.
    发明授权
    2-(2,4,5-substituted-anilino) pyrimidine compounds 有权
    2-（2,4,5-取代 - 苯胺基）嘧啶化合物

    公开(公告)号：US08946235B2

    公开(公告)日：2015-02-03

    申请号：US13557871

    申请日：2012-07-25

    申请人： Sam Butterworth ,  Maurice Raymond Verschoyle Finlay ,  Richard Andrew Ward ,  Heather Marie Redfearn

    发明人： Sam Butterworth ,  Maurice Raymond Verschoyle Finlay ,  Richard Andrew Ward ,  Heather Marie Redfearn

    IPC分类号： A61K31/404 ,  C07D401/04 ,  C07D401/02 ,  C07D403/04 ,  C07D471/04

    CPC分类号： C07D401/04 ,  A61P35/00 ,  C07D401/02 ,  C07D401/14 ,  C07D403/04 ,  C07D471/04 ,  C07D487/10

    摘要： The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using such compounds and salts thereof.

    摘要翻译： 本发明涉及某些2-（2,4,5-取代 - 苯胺基）嘧啶化合物及其药学上可接受的盐，其可用于治疗或预防通过某些突变形式的表皮生长因子介导的疾病或医学病症 受体（例如L858R激活突变体，Exon19缺失激活突变体和T790M抗性突变体）。 这些化合物及其盐可用于治疗或预防多种不同的癌症。 本发明还涉及包含所述化合物及其盐的药物组合物，这些化合物和盐的特别有用的多晶型物，可用于制备所述化合物的中间体以及使用这些化合物治疗由各种不同形式的EGFR介导的疾病的方法，以及 的盐。

    2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS
    6.
    发明申请
    2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开
    作为TTK / MPS1抑制剂的2-ANILINOPURIN-8-ONES用于治疗增殖性疾病

    公开(公告)号：US20110118238A1

    公开(公告)日：2011-05-19

    申请号：US12674749

    申请日：2008-08-20

    申请人： David Michael Andrews ,  Clifford David Jones ,  Iain Simpson ,  Richard Andrew Ward

    发明人： David Michael Andrews ,  Clifford David Jones ,  Iain Simpson ,  Richard Andrew Ward

    IPC分类号： A61K31/5513 ,  C07D473/00 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/541 ,  A61P35/00

    CPC分类号： C07D487/04

    摘要： This invention relates to chemical compounds of the formula (I), or a pharmaceutically acceptable salt thereof, which possess inhibitory activity against the spindle checkpoint kinase: Tyrosine Threonine Kinase (TTK)/monopolar spindle 1 (Mps1) and are accordingly useful for their anti-cancer effect in a warm-blooded animal such as man. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them, and to their use in the manufacture of a medicament for the treatment of conditions mediated by TTK/Mps1, for use either alone or in combination with other anti-pro liferative agents.

    摘要翻译： 本发明涉及对主轴检查点激酶：酪氨酸苏氨酸激酶（TTK）/单极纺锤体1（Mps1）具有抑制活性的式（I）化合物或其药学上可接受的盐，因此可用于其抗 - 在温血动物如男人中的癌症效应。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在制备用于治疗由TTK / Mps1介导的病症的药物中的用途，用于单独使用或与其它组合使用 抗衰老剂。