公开(公告)号：US4247401A

公开(公告)日：1981-01-27

申请号：US938496

申请日：1978-08-31

Applicant: Rene Bloch ,  Jacov Yonath

Inventor： Rene Bloch ,  Jacov Yonath

IPC: B01D13/00

CPC classification number: B01D61/025 ,  B01D67/0093 ,  B01D69/141 ,  B01D71/16

Abstract: A method for the separation of organic or metallo-organic substances from salts by reverse osmosis is provided. The membranes used are asymmetric acetyl cellulose membranes modified by covalently bonded residues of reactive dyestuffs containing ionizable groups. The diameter of the pores on the surface of the membrane is 5 to 100 A.

Abstract translation: 提供了通过反渗透从盐分离有机或金属有机物质的方法。 所使用的膜是通过含有可电离基团的活性染料的共价键残基修饰的不对称乙酰纤维素膜。 膜表面的孔直径为5〜100 A.

公开(公告)号：US3965255A

公开(公告)日：1976-06-22

申请号：US466018

申请日：1974-05-01

Applicant: Rene Bloch ,  Ora Kedem ,  Ester Lobel

Inventor： Rene Bloch ,  Ora Kedem ,  Ester Lobel

IPC: A61K9/22 ,  A61K9/28 ,  A61K9/24 ,  A61K9/32 ,  A61K9/58

CPC classification number: A61K9/282 ,  A61K9/284

Abstract: A drug delivery preparation with controlled release time and rate, comprising a therapeutic agent being encapsulated in or coated by a solvent membrane, as well as a process for the manufacture thereof, are disclosed.

Abstract translation: 公开了具有控制释放时间和速率的药物递送制剂，其包含封装在溶剂膜中或由溶剂膜包被的治疗剂及其制备方法。

公开(公告)号：US4101380A

公开(公告)日：1978-07-18

申请号：US695030

申请日：1976-06-11

Applicant: Menachem Rubinstein ,  Shulamit Simon ,  Rene Bloch, deceased

Inventor： Menachem Rubinstein ,  Shulamit Simon ,  Rene Bloch, deceased

IPC: C08H1/00 ,  C07G7/02 ,  C07G7/00

CPC classification number: C08H1/00 ,  Y10S530/816

Abstract: The invention relates to a process for the cross-linking of proteins wherein the proteins to be cross-linked are reacted with a cross-linking agent selected from the group consisting of:(a) water soluble poly(ethylene oxide) derivatives of the general formula I(z).sub.m --Y--(CH.sub.2 CH.sub.2 O).sub.n CH.sub.2 CH.sub.2 --Y--(Z).sub.m(I)wherein both n and m are at least 1; Y is a covalent bond or is an --R-- or --RO-- radical in which the oxygen is bound to the poly(ethylene oxide) and R is selected from the group consisting of methylene, ethylene, propylene, o--, m-- and p-phenylene, o--, m-- and p-phenylene carbamate optionally substituted by one or more alkyl, aryl, halo, nitro, oxo, carboxy, hydroxy, thio, sulfonate and phosphate groups; and Z is a reactive group selected from the groups consisting of halo-isocyanato-, isothiocyanato-, tosylate, acyl halides, acyl azides, aryl diazonium salts, acyl imidoester salts, activated esters of acyl residues and 2,4-dichlorotriazines; and(b) activated esters of di- and poly-carboxylic acids wherein the acids and the alcohol moieties thereof are water soluble.

Abstract translation: 本发明涉及蛋白质交联的方法，其中待交联的蛋白质与选自以下的交联剂反应：