公开(公告)号：US20090155361A1

公开(公告)日：2009-06-18

申请号：US12063951

申请日：2006-08-18

申请人： Masahiko Narasaki ,  Tomoya Akutagawa ,  Reiko Oku

发明人： Masahiko Narasaki ,  Tomoya Akutagawa ,  Reiko Oku

IPC分类号： A61K9/22 ,  A61K9/20 ,  A61K9/28

CPC分类号： A61K9/2072 ,  A61K9/209 ,  A61K9/2866

摘要： A tablet which is either a two-layer tablet comprising a layer A and a layer B or a three-layer tablet comprising a layer A, a layer B and a layer C in that order, wherein the layer B is a medicinal additive layer, the layer A and the layer C are drug layers that are segmented on the layer B, and the sections of the layer A and the layer C are held on the layer B and contain either the same or different drugs. Also, a scored tablet wherein splitting at one of the score lines produces two fragments with equal drug contents and splitting at the other score line produces two fragments with unequal drug contents. In addition, a scored tablet wherein splitting at the score lines exposes cross-sections with different drug release-controlling functions.

摘要翻译： 片剂，其为依次层叠A层和B层的双层片剂或包含A层，B层和C层的三层片剂，其中，B层为药用添加剂层， 层A和层C是分层在层B上的药物层，层A和层C的部分保持在层B上并含有相同或不同的药物。 另外，一个刻痕片，其中一条记分线上的分裂产生具有相同药物含量的两个片段，并且在另一个刻痕线处分裂产生具有不相等药物含量的两个片段。 另外，在刻痕线处分割的刻痕片暴露具有不同药物释放控制功能的横截面。

公开(公告)号：US20090110726A1

公开(公告)日：2009-04-30

申请号：US12063721

申请日：2006-08-17

申请人： Masahiko Narasaki ,  Tomoya Akutagawa ,  Reiko Oku

发明人： Masahiko Narasaki ,  Tomoya Akutagawa ,  Reiko Oku

IPC分类号： A61K9/44 ,  B29C43/02

CPC分类号： A61K9/2072 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2077 ,  A61K9/2086

摘要： The present invention provides a tablet comprising a plurality of drug-containing parts and at least one connecting part adhered to the drug-containing parts, and having a scored line capable of dividing the whole tablet on the connecting part; particularly, a coated tablet in which a connecting part and a coating layer have the same or different drug release controlling functions; a tablet having an insoluble coating on a drug-containing part having a scored line, wherein the drug-containing part has a structure or composition such that the drug is substantially released after the tablet is divided along the scored line and then ingested; and a tablet comprising a plurality of drug-containing parts and at least one connecting part adhered to the drug-containing parts, wherein at least two drug-containing parts have different compositions.In addition, the present invention provides a method of manufacturing a tablet, wherein a column comprising a plurality of columnar pharmaceutical composition layers having the same cross-section and laminated in the axial direction of the column is compression molded and then compression molded in a direction different from the axial direction of the column.

摘要翻译： 本发明提供了一种片剂，其包含多个药物含有部分和至少一个连接部分，所述至少一个连接部分粘附到所述药物包含部分，并且具有能够在所述连接部分上分割整个片剂的刻痕线; 特别是其中连接部分和涂层具有相同或不同的药物释放控制功能的包衣片剂; 在具有刻痕线的药物含有部分上具有不溶性涂层的片剂，其中所述药物含有部分具有使得所述药物在所述片剂沿着刻痕线分割然后摄取后基本上释放的结构或组成; 以及包含多个药物含有部分和至少一个粘附到所述药物含有部分的连接部分的片剂，其中至少两个药物含有部分具有不同的组成。 此外，本发明提供一种片剂的制造方法，其特征在于，将具有相同截面并在所述柱的轴向层叠的多个柱状药物组合物层的柱压缩成型，然后在 不同于柱的轴向。

公开(公告)号：US09028867B2

公开(公告)日：2015-05-12

申请号：US12063721

申请日：2006-08-17

申请人： Masahiko Narasaki ,  Tomoya Akutagawa ,  Reiko Oku

发明人： Masahiko Narasaki ,  Tomoya Akutagawa ,  Reiko Oku

IPC分类号： A61K9/20

CPC分类号： A61K9/2072 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2077 ,  A61K9/2086

摘要： The present invention provides a tablet comprising a plurality of drug-containing parts and at least one connecting part adhered to the drug-containing parts, and having a scored line capable of dividing the whole tablet on the connecting part; particularly, a coated tablet in which a connecting part and a coating layer have the same or different drug release controlling functions; a tablet having an insoluble coating on a drug-containing part having a scored line, wherein the drug-containing part has a structure or composition such that the drug is substantially released after the tablet is divided along the scored line and then ingested; and a tablet comprising a plurality of drug-containing parts and at least one connecting part adhered to the drug-containing parts, wherein at least two drug-containing parts have different compositions.In addition, the present invention provides a method of manufacturing a tablet, wherein a column comprising a plurality of columnar pharmaceutical composition layers having the same cross-section and laminated in the axial direction of the column is compression molded and then compression molded in a direction different from the axial direction of the column.

摘要翻译： 本发明提供了一种片剂，其包含多个药物含有部分和至少一个连接部分，所述至少一个连接部分粘附到所述药物包含部分，并且具有能够在所述连接部分上分割整个片剂的刻痕线; 特别是其中连接部分和涂层具有相同或不同的药物释放控制功能的包衣片剂; 在具有刻痕线的药物含有部分上具有不溶性涂层的片剂，其中所述药物含有部分具有使得所述药物在所述片剂沿着刻痕线分割然后摄取后基本上释放的结构或组成; 以及包含多个药物含有部分和至少一个粘附到所述药物含有部分的连接部分的片剂，其中至少两个药物含有部分具有不同的组成。 此外，本发明提供一种片剂的制造方法，其特征在于，将具有相同截面并在所述柱的轴向层叠的多个柱状药物组合物层的柱压缩成型，然后在 不同于柱的轴向。