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    LOW DOSE PHARMACEUTICAL COMPOSITION OF DOXYCYCLINE
    3.
    发明申请
    LOW DOSE PHARMACEUTICAL COMPOSITION OF DOXYCYCLINE 审中-公开
    DOXYCYCLINE的低剂量药物组合物

    公开(公告)号：US20160143923A1

    公开(公告)日：2016-05-26

    申请号：US14548915

    申请日：2014-11-20

    申请人： RANBAXY LABORATORIES LIMITED

    发明人： Anuj Kumar FANDA ,  Romi Barat SINGH

    IPC分类号： A61K31/65

    CPC分类号： A61K31/65 ,  A61K9/4866

    摘要： The present invention relates to a low dose pharmaceutical composition comprising 32 mg or 34 mg doxycycline and one or more pharmaceutically acceptable excipients for the treatment of acne, and processes for its preparation.

    摘要翻译： 本发明涉及包含32mg或34mg多西环素和一种或多种用于治疗痤疮的药学上可接受的赋形剂的低剂量药物组合物及其制备方法。

    PURE CRYSTALLINE FORM II OF L-MALIC ACID SALT OF SUNITINIB AND PROCESSES FOR ITS PREPARATION
    6.
    发明申请
    PURE CRYSTALLINE FORM II OF L-MALIC ACID SALT OF SUNITINIB AND PROCESSES FOR ITS PREPARATION 有权
    堇青霉素的L-马来酸盐的纯晶体形式II及其制备方法

    公开(公告)号：US20150112085A1

    公开(公告)日：2015-04-23

    申请号：US14147757

    申请日：2014-01-06

    申请人： Ranbaxy Laboratories Limited

    发明人： Hari Babu MATTA ,  Mahavir Singh KHANNA ,  Mohan PRASAD

    IPC分类号： C07D403/06 ,  C07C59/245

    CPC分类号： C07D403/06 ,  C07C59/245

    摘要： The present invention relates to pure crystalline Form II of an L-malic acid salt of sunitinib and a process for its preparation. The invention further provides crystalline Form II of an L-malic acid salt of sunitinib having a purity of at least 97.0%. The invention also provides crystalline Form II of an L-malic acid salt of sunitinib substantially free of an anti-oxidant. The invention also provides crystalline Form II of L-malic acid salt of sunitinib which remains chemically pure on storage at 25° C.±2° C. and 40° C.±2° C. at a relative humidity of 60%±5% and 75%±5%, respectively, for at least 1 month.

    摘要翻译： 本发明涉及舒尼替尼的L-苹果酸盐的纯结晶形式II及其制备方法。 本发明还提供了纯度为至少97.0％的舒尼替尼的L-苹果酸盐的晶型II。 本发明还提供基本上不含抗氧化剂的舒尼替尼的L-苹果酸盐的晶型II。 本发明还提供舒尼替尼的L-苹果酸盐的结晶形式II，其在25℃±2℃和40℃±2℃下在相对湿度60％±5℃下保存为化学纯的 ％和75％±5％，至少1个月。

    PROCESS FOR THE PREPARATION OF AN INTERMEDIATE OF TADALAFIL
    9.
    发明申请
    PROCESS FOR THE PREPARATION OF AN INTERMEDIATE OF TADALAFIL 有权
    制备TADALAFIL中间体的方法

    公开(公告)号：US20140142309A1

    公开(公告)日：2014-05-22

    申请号：US13860262

    申请日：2013-04-10

    申请人： RANBAXY LABORATORIES LIMITED

    发明人： Dattatray B. PATIL ,  Killol Patel ,  Ashok Prasad ,  Mohan Prasad

    IPC分类号： C07D471/14

    CPC分类号： C07D471/14 ,  C07D471/04 ,  C07D471/12

    摘要： The present invention relates to a process for the preparation of a cis-intermediate compound of Formula II which is a useful synthetic intermediate for the preparation of tadalafil of Formula I—a potent, selective, and reversible inhibitor of cyclic guanosine 3′,5′-monophosphate specific phosphodiesterase type 5 enzyme having phosphodiesterase inhibitory activity.

    摘要翻译： 本发明涉及一种制备式II的顺 - 中间体化合物的方法，其为制备式I的他达他必利的有用的合成中间体 - 一种有效的，选择性的和可逆的环鸟嘌呤3'，5' 具有磷酸二酯酶抑制活性的单磷酸特异性磷酸二酯酶5型酶。