公开(公告)号：US20230120282A1

公开(公告)日：2023-04-20

申请号：US17980864

申请日：2022-11-04

申请人： Progentec Diagnostics, Inc.

发明人： Mohan Purushothaman ,  Arif Latif Sorathia

IPC分类号： G16H20/10 ,  G16H10/60 ,  G16H15/00 ,  G06N3/08 ,  G16H80/00 ,  G16B40/20 ,  G16H50/20

摘要： An artificial intelligence (AI) system and methods for management of an autoimmune or inflammatory condition, disorder or disease in a patient for the diagnosis, prognosis, or risk assessment of symptoms thereof. The AI system includes patient and provider applications and a payer application interface accessible via a communications network. The system contains a data-driven recommendation engine using machine learning and/or deep learning based on active monitoring of patients with an autoimmune or inflammatory-related condition, disorder, or disease. The system can alert clinicians to an impending symptom flare and provide a treatment solution that reduces symptom severity, reduces or eliminates the onset.

公开(公告)号：US20210396751A1

公开(公告)日：2021-12-23

申请号：US17411724

申请日：2021-08-25

申请人： Progentec Diagnostics, Inc. ,  Oklahoma Medical Research Foundation

发明人： Melissa MUNROE ,  Judith JAMES ,  Eldon JUPE ,  Mohan PURUSHOTHAMAN

IPC分类号： G01N33/564 ,  G01N33/68

摘要： A method for characterizing disease activity in a systemic lupus erythematosus patient (SLE), comprising obtaining a dataset associated with a blood, serum, plasma or urine sample from the patient, assessing the dataset for a presence or an amount of protein expression of at least one innate serum or plasma mediator, assessing the dataset for a presence or an amount of protein expression of at least one adaptive serum or plasma mediator biomarker, assessing the dataset for a presence or an amount of at least one chemokine/adhesion molecule biomarker, assessing the dataset for a presence or an amount of at least one soluble TNF superfamily biomarker, assessing the dataset for a presence or an amount of at least one inflammatory mediator biomarker, assessing the dataset for a presence or an amount at least one SLE-associated autoantibody specificity biomarker and calculating a Lupus Disease Activity Immune Index (LDAII) score.

公开(公告)号：US11257579B2

公开(公告)日：2022-02-22

申请号：US16866498

申请日：2020-05-04

申请人： Progentec Diagnostics, Inc.

发明人： Mohan Purushothaman ,  Arif Latif Sorathia

IPC分类号： G16H20/10 ,  G16H10/60 ,  G16H15/00 ,  G06N3/08 ,  G16H80/00 ,  G16B40/20 ,  G16H50/20

摘要： An artificial intelligence (AI) system and methods for management of an autoimmune or inflammatory condition, disorder or disease in a patient for the diagnosis, prognosis, or risk assessment of symptoms thereof. The AI system includes patient and provider applications and a payer application interface accessible via a communications network. The system contains a data-driven recommendation engine using machine learning and/or deep learning based on active monitoring of patients with an autoimmune or inflammatory-related condition, disorder, or disease. The system can alert clinicians to an impending symptom flare and provide a treatment solution that reduces symptom severity, reduces or eliminates the onset.

公开(公告)号：US20240011983A1

公开(公告)日：2024-01-11

申请号：US18016384

申请日：2021-07-21

申请人： Progentec Diagnostics, Inc. ,  Oklahoma Medical Research Foundation

发明人： Melissa MUNROE ,  Judith JAMES ,  Eldon JUPE ,  Mohan PURUSHOTHAMAN

IPC分类号： G01N33/564

CPC分类号： G01N33/564 ,  G01N2333/96494 ,  G01N2333/54 ,  G01N2333/525 ,  G01N2800/104

摘要： A method for determining whether a Systemic lupus erythematosus (SLE) patient is undergoing a pre-flare event, the method comprising obtaining a blood, serum, plasma, or saliva sample from the SLE patient; assessing a level of expression for each of a plurality of biomarkers, the plurality of biomarkers comprising OPN, MCP-1/CCL2, MCP-3/CCL7, IL-17A, TNFRII, TNFRI, IL-4, IL-5, BLyS, TNFα, and IL-7; determining a Lupus Flare Risk Prediction Index (LFPI) for the patient based upon the level of expression for each of a plurality of biomarkers; and based upon the LFPI, determining whether the patient is undergoing a pre-flare event.

公开(公告)号：US20210343384A1

公开(公告)日：2021-11-04

申请号：US16866498

申请日：2020-05-04

申请人： Progentec Diagnostics, Inc.

发明人： Mohan Purushothaman ,  Arif Latif Sorathia

IPC分类号： G16H20/10 ,  G16H10/60 ,  G16H15/00 ,  G16H50/20 ,  G16H80/00 ,  G16B40/20 ,  G06N3/08

摘要： An artificial intelligence (AI) system and methods for management of an autoimmune or inflammatory condition, disorder or disease in a patient for the diagnosis, prognosis, or risk assessment of symptoms thereof. The AI system includes patient and provider applications and a payer application interface accessible via a communications network. The system contains a data-driven recommendation engine using machine learning and/or deep learning based on active monitoring of patients with an autoimmune or inflammatory-related condition, disorder, or disease. The system can alert clinicians to an impending symptom flare and provide a treatment solution that reduces symptom severity, reduces or eliminates the onset.