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    Liposomal vector for active-principle
    1.
    发明授权
    Liposomal vector for active-principle 失效
    用于活性成分的脂质体载体

    公开(公告)号：US06656497B2

    公开(公告)日：2003-12-02

    申请号：US09445444

    申请日：2000-02-17

    申请人： Jean-Pierre Salles

    发明人： Jean-Pierre Salles

    IPC分类号： A61K9127

    CPC分类号： A61K9/127 ,  A61K9/1277 ,  Y10S514/824 ,  Y10T428/2984

    摘要： The invention concerns liposome vectors, in powder form, of active principles, and more particularly active principles sensitive to digestive and/or plasmatic degradation, such as proteins, and their application as medicine. Said liposome vectors of active principles consist of a powder composition essentially constituted of unilamellar liposomes comprising an external lipid phase consisting of class 4 lipids (phospholipids), optionally associated with class 2 substances, class 3 substances and/or class 5 substances and an internal aqueous nucleus consisting of a mixture M of at least two different non-polymerisable gelling agents (G1 and G2) whereof the gel-sol phase transition is not less than 37° C., G1 being selected among gelatines and carrageenans and G2 being selected among carrageenans with properties different from the carrageenans selected for G1, and celluloses, which liposomes have a diameter ranging between 20 nm and 1 mm, preferably between 20 nm and 500 nm; said composition having the form of particulate units with an average particle diameter between 10 mm and 1000 mm, formed by one or several of said liposomes, enclosed in a sheath selected in the group consisting of a dehydrated thermoreversible aqueous gel identical to said internal nucleus aqueous gel, dextrins or a mixture thereof, such that they contain, on an average, 10 to 10 liposomes per gram of powder; and at least an active principle contained, as the case may be, either in the gelled internal nucleus or in the external lipid phase.

    摘要翻译： 本发明涉及以粉末形式的活性成分的脂质体载体，更特别的是对消化和/或血浆降解敏感的活性成分，例如蛋白质，以及它们作为药物的应用。 所述活性成分的脂质体载体由基本上由单层脂质体组成的粉末组合物组成，所述脂质体包含任选与2类物质，3类物质和/或5类物质组成的4类脂质（磷脂）组成的外部脂质相， 由至少两种不同的不可聚合胶凝剂（G1和G2）的混合物M组成，其中凝胶 - 溶胶相变不小于37℃，G1选自明胶和角叉菜胶，G2选自角叉菜胶 具有与选择用于G1的角叉菜胶不同的性质，以及纤维素，其脂质体的直径范围在20nm和1mm之间，优选在20nm和500nm之间; 所述组合物具有由一种或几种所述脂质体形成的平均粒径为10mm至1000mm的颗粒单元的形式，所述颗粒单元被包封在选自由所述内核水相同的脱水的热可逆水性凝胶组成的组中 凝胶，糊精或其混合物，使得它们平均每克粉末含有10至10个脂质体; 并且至少一种活性成分（视情况而定）包含在凝胶内核或外部脂质相中。

    CONNECTION ASSEMBLY WITH FRONT CABLING FOR AT LEAST ONE ITEM OF ELECTRONIC EQUIPMENT IN AN AIRCRAFT
    2.
    发明申请
    CONNECTION ASSEMBLY WITH FRONT CABLING FOR AT LEAST ONE ITEM OF ELECTRONIC EQUIPMENT IN AN AIRCRAFT 审中-公开
    连接装配前端电子装置用于飞机上的电子设备

    公开(公告)号：US20110194269A1

    公开(公告)日：2011-08-11

    申请号：US13021511

    申请日：2011-02-04

    申请人： Emile COLONGO ,  Pierre Salles

    发明人： Emile COLONGO ,  Pierre Salles

    IPC分类号： H05K7/00

    CPC分类号： H05K7/1448

    摘要： The invention relates to a connection assembly (1) for at least one item of electronic equipment (2) to the wiring (3) of an aircraft, in which the said at least one item of electronic equipment (2) is disposed in a support means (4) and comprises connection means able to be connected to the wiring (3) of the aircraft through at least one connection interface (6), characterized in that the said at least one connection interface (6) is connected to the wiring (3) through a wiring box (30) interposed between the said interface (6) and the wiring (3), the said wiring box (30) being disposed in the support means (4) to provide the connection between the connection interface (6) and the wiring (3) through the said support means (4), the support means (4) comprising a front face (16) and a rear face (18) on which the said at least one connection interface (6) is disposed, the connection assembly (1) comprising a cable passage (31) in which the wiring (3) is disposed and which extends to the vicinity of the front face (16) of the support means.

    摘要翻译： 本发明涉及一种用于飞机的布线（3）的至少一个电子设备（2）的至少一个物品的连接组件（1），其中所述至少一个电子设备物品（2）设置在支架 装置（4）并且包括能够通过至少一个连接接口（6）连接到飞机的布线（3）的连接装置，其特征在于，所述至少一个连接接口（6）连接到布线 3）通过介于所述接口（6）和布线（3）之间的接线盒（30），所述接线盒（30）设置在支撑装置（4）中，以提供连接接口（6） ）和通过所述支撑装置（4）的布线（3），所述支撑装置（4）包括前表面（16）和后表面（18），所述至少一个连接接口（6）设置在所述前面 ，所述连接组件（1）包括其中布置所述布线（3）并且延伸到所述布线（3）的电缆通道（31） 靠近支撑装置的前表面（16）。

    Gelified microspheres, their method of preparation and their applications
    3.
    发明授权
    Gelified microspheres, their method of preparation and their applications 失效
    凝胶微球，其制备方法及其应用

    公开(公告)号：US06221387B1

    公开(公告)日：2001-04-24

    申请号：US09300435

    申请日：1999-04-28

    申请人： Jacques Hauton ,  Jean-Pierre Salles

    发明人： Jacques Hauton ,  Jean-Pierre Salles

    IPC分类号： A61K9127

    CPC分类号： A61K9/5192 ,  A61K9/1271 ,  A61K9/1277 ,  A61K9/5123 ,  A61K9/5138 ,  A61K9/5161 ,  A61K9/5169 ,  Y10T428/2984

    摘要： Microspheres comprising a gelified polar core which is optionally surrounded by concentric and alternating superimposed n lipidic bilayers or n aqueous liquid layers and n gelified polar layers, n being an integer. The microspheres of the invention are obtainable by delipidation of liposomes designated as liposomes having a gelified polar core, of the type comprising at least one outer lipidic bilayer and at least one inner polar aqueous phase containing a gelified substance.

    摘要翻译： 微球包含凝胶化的极性核，其任选地被同心和交替重叠的n个脂质双层或n个水性液体层和n个凝胶化的极性层包围，n是整数。 本发明的微球可以通过称为脂质体的脂质体脱脂来获得，所述脂质体具有凝胶化的极性核心，其类型包括至少一个外部脂质双层和至少一个含有凝胶化物质的内部极性水相。

    Gelified microspheres, their method of preparation and their applications
    5.
    发明授权
    Gelified microspheres, their method of preparation and their applications 失效
    凝胶微球，其制备方法及其应用

    公开(公告)号：US5945120A

    公开(公告)日：1999-08-31

    申请号：US722173

    申请日：1996-12-13

    申请人： Jacques Hauton, deceased ,  Jean-Pierre Salles

    发明人： Jacques Hauton, deceased ,  Jean-Pierre Salles

    IPC分类号： A61K9/127 ,  A61K9/16 ,  A61K9/51 ,  A61K49/00 ,  B01J13/14

    CPC分类号： A61K9/5192 ,  A61K9/1271 ,  A61K9/1277 ,  A61K9/5123 ,  A61K9/5138 ,  A61K9/5161 ,  A61K9/5169 ,  Y10T428/2984

    摘要： Microspheres comprising a gelified polar core which is optionally surrounded by concentric and alternating superimposed n lipidic bilayers or n aqueous liquid layers and n gelified polar layers, n being an integer. The microspheres of the invention are obtainable by delipidation of liposomes designated as liposomes having a gelified polar core, of the type comprising at least one outer lipidic bilayer and at least one inner polar aqueous phase containing a gelified substance.

    摘要翻译： PCT No.PCT / FR95 / 00473 Sec。 371日期1996年12月13日第 102（e）日期1996年12月13日PCT提交1995年4月12日PCT公布。 公开号WO95 / 27477 日期1995年10月19日微球包含凝胶化的极性核心，其任选被同心和交替重叠的n个脂质双层或n个水性液体层和n个凝胶化的极性层包围，n是整数。 本发明的微球可以通过称为脂质体的脂质体脱脂来获得，所述脂质体具有凝胶化的极性核心，其类型包括至少一个外部脂质双层和至少一个含有凝胶化物质的内部极性水相。

    Modular assembly for fastening electronic modules
    6.
    发明授权
    Modular assembly for fastening electronic modules 有权
    用于紧固电子模块的模块化组件

    公开(公告)号：US08760873B2

    公开(公告)日：2014-06-24

    申请号：US13085969

    申请日：2011-04-13

    申请人： Pierre Salles

    发明人： Pierre Salles

    IPC分类号： H05K5/00

    CPC分类号： H05K7/1412 ,  H05K7/20145

    摘要： The invention relates to a modular assembly for fastening electronic modules carried on board an aircraft, characterized in that it comprises: a frame (10) having a more or less planar vertical front surface, comprising several mechanical fastening interfaces each intended for mechanically fastening an electronic module, at least one electronic module (80) comprising a mechanical fastening interface and which is attached to the front surface of the frame in suspended position via cooperation of the mechanical fastening interface of the said at least one electronic module with one of the mechanical fastening interfaces of the frame.

    摘要翻译： 本发明涉及一种用于紧固承载在飞机上的电子模块的模块化组件，其特征在于，其包括：具有或多或少平面的垂直前表面的框架（10），其包括多个机械紧固接口，每个机械紧固接口用于机械地紧固电子 模块，至少一个电子模块（80），其包括机械紧固接口，并且通过所述至少一个电子模块的机械紧固界面与所述机械紧固件之一的配合而在悬挂位置附接到所述框架的前表面 框架的接口。

    Powder compositions of unilamellar liposomes
    9.
    发明授权
    Powder compositions of unilamellar liposomes 失效
    单层脂质体的粉末组成

    公开(公告)号：US06331315B1

    公开(公告)日：2001-12-18

    申请号：US09445441

    申请日：2000-02-16

    申请人： Jean-Pierre Salles

    发明人： Jean-Pierre Salles

    IPC分类号： A61K9127

    CPC分类号： A61K31/685 ,  A61K9/127 ,  A61K9/1277 ,  Y10S514/824 ,  Y10S977/907 ,  Y10T428/2984

    摘要： The invention concerns powder compositions of stabilised unilamellar liposomes, comprising at least an external lipid phase and a internal aqueous polar nucleus gelled at room temperature, the method for preparing them and their applications as nutritional additives and in pharmaceutical compositions to be orally administered (with action against lipemia). Said compositions essentially consist of unilamellar liposomes comprising an external lipid phase consisting of class 4 lipids (phospholipids) and an internal aqueous nucleus consisting essentially of a mixture M of at least two different non-polymerisable gelling agents (G1 and G2) whereof the gel-sol phase transition point is not less than 37° C., G1 being a gelling agent selected among gelatines and carrageenans and G2 being selected among carrageenans with properties different from the carrageenans selected for G1, and celluloses, which lipisomes have a diameter ranging between 20 nm and 1 mm, preferably ranging between 50 nm and 500 nm and having the form of particulate units with an average particle diameter between 10 mm and 1000 mm, formed by one or several of said liposomes, enclosed in a sheath selected in the group consisting of a dehydrated thermoreversible aqueous gel identical to said internal nucleus aqueous gel, dextrins or a mixture thereof, such that they contain, on an average, 1016 to 1018 liposomes per gram of powder.

    摘要翻译： 本发明涉及稳定的单层脂质体的粉末组合物，其包含至少外部脂质相和在室温下凝胶化的内部含水极性核，其制备方法及其作为营养添加剂的应用和用于口服给药的药物组合物（具有作用 抗脂血症）。 所述组合物基本上由单层脂质体组成，其包含由4类脂质（磷脂）组成的外部脂质相和基本上由至少两种不同的不可聚合胶凝剂（G1和G2）的混合物M组成的内部水核， 溶胶相转变点不低于37℃，G1是选自明胶和角叉菜胶的胶凝剂，G2选自具有不同于选自G1的角叉菜胶的性质的角叉菜胶，以及纤维素，该脂肪体的直径范围为20 nm和1mm，优选在50nm和500nm之间，并且具有由一个或几个所述脂质体形成的平均粒径在10mm和1000mm之间的颗粒单元的形式，所述颗粒单元被包封在选自以下的组中： 与所述内核水性凝胶相同的脱水热可逆水性凝胶，糊精或其混合物，使得它们含有 平均每克粉末1016至1018个脂质体。

    Connection assembly for at least one item of electronic equipment in an aircraft
    10.
    发明授权
    Connection assembly for at least one item of electronic equipment in an aircraft 有权
    航空器中至少一件电子设备的连接组件

    公开(公告)号：US08717776B2

    公开(公告)日：2014-05-06

    申请号：US13021432

    申请日：2011-02-04

    申请人： Emile Colongo ,  Pierre Salles

    发明人： Emile Colongo ,  Pierre Salles

    IPC分类号： H05K7/02 ,  H05K7/04

    CPC分类号： H05K7/1449

    摘要： An assembly for connection of an electronic equipment item to wiring of an aircraft, in which the item of electronic equipment is disposed in a support means and includes connection means configured to be connected to the wiring, a connection interface disposed between the wiring and the connection means to provide connection of the item of electronic equipment to the wiring, the connection assembly configured to change over from a connected state in which the connection means are connected to the connection interface to a disconnected state in which the connection means are free. The connection interface is fastened to the structure of the aircraft; whether the connection assembly is in the connected or disconnected state. The support means is movable and includes an at least partially open face turned toward the connection interface and onto which the connection means emerge. The connection of the connection assembly to the connection interface is made by moving the support means between a first position where the connection assembly is in a disconnected state and a second position where it is in a connected state.

    摘要翻译： 一种用于将电子设备项目连接到飞行器的布线的组件，其中电子设备的项目被布置在支撑装置中并且包括被配置为连接到布线的连接装置，布置在布线和连接之间的连接接口 用于提供电子设备项目与布线的连接的装置，所述连接组件被配置为从所述连接装置连接到所述连接接口的连接状态切换到所述连接装置是空闲的断开状态。 连接接口固定在飞机的结构上; 连接组件是否处于连接或断开状态。 支撑装置是可移动的并且包括朝向连接界面转动的至少部分开放的表面，连接装置出现在该至少部分开口面上。 通过在连接组件处于断开状态的第一位置和处于连接状态的第二位置之间移动支撑装置来实现连接组件与连接接口的连接。