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1.发明授权公开(公告)号：US11782049B2
公开(公告)日：2023-10-10
申请号：US16805142
申请日：2020-02-28
申请人： Picomole Inc.
CPC分类号： G01N33/497 , A61B5/087 , A61B5/093 , G01N33/0009 , G01N33/5008 , A61B2010/0087 , G01N2033/4975
摘要： An apparatus and method for collecting a breath sample are provided. The apparatus has a breath input interface configured to receive exhaled breath, a container connected to the breath input interface for receiving at least some of the exhaled breath, the container having a cavity with a volume that is controllable, and at least one controller configured to control the volume of the cavity to increase at a volume increase rate that is at most equal to a flow rate of the exhaled breath received by the breath input interface.
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2.发明申请公开(公告)号：US20210267478A1
公开(公告)日：2021-09-02
申请号：US16805142
申请日：2020-02-28
申请人： Picomole Inc.
IPC分类号： A61B5/087 , A61B5/093 , G01N33/497 , G01N33/00 , G01N33/50
摘要： An apparatus and method for collecting a breath sample are provided. The apparatus has a breath input interface configured to receive exhaled breath, a container connected to the breath input interface for receiving at least some of the exhaled breath, the container having a cavity with a volume that is controllable, and at least one controller configured to control the volume of the cavity to increase at a volume increase rate that is at most equal to a flow rate of the exhaled breath received by the breath input interface.
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公开(公告)号：US11788957B2
公开(公告)日：2023-10-17
申请号：US17443873
申请日：2021-07-28
申请人： Picomole Inc.
发明人： Gisia Beydaghyan , Christopher Quentin Purves , Stephen Douglas Graham , Erik Justin Scheme , Angkoon Phinyomark
IPC分类号： G01N21/39 , G01N33/497 , G01N1/40 , G01J3/42 , G01N21/3504 , G01N21/552 , G01J3/02 , G01N21/31 , G01J3/10 , G06N20/00 , G01N21/77
CPC分类号： G01N21/39 , G01J3/0205 , G01J3/10 , G01J3/42 , G01N1/40 , G01N21/31 , G01N21/3504 , G01N21/552 , G01N33/497 , G01J2003/423 , G01N2021/391 , G01N2021/398 , G01N2021/7789 , G01N2033/4975 , G06N20/00
摘要： Methods and systems for analyzing a sample and generating a predictive model using cavity ring-down spectroscopy are disclosed. At least part of a sample is loaded in a ring-down cavity. For each of a set of wavelengths, a laser beam is generated and directed into the ring-down cavity. The laser beam entering the ring-down cavity is extinguished. Light intensity decay data for light exiting the ring-down cavity is registered via a light intensity sensor system. A probability is determined from the light intensity decay data for the set of wavelengths that a subject from which the sample was received has a physiological condition or a degree of the physiological condition at least indirectly using a dataset of light intensity decay data for previously analyzed samples for which the presence or the absence of the physiological condition or the degree of the physiological condition have been identified.
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公开(公告)号：US11105739B2
公开(公告)日：2021-08-31
申请号：US16740026
申请日：2020-01-10
申请人： Picomole Inc.
发明人： Gisia Beydaghyan , Christopher Quentin Purves , Stephen Douglas Graham , Erik Justin Scheme , Angkoon Phinyomark
IPC分类号： G01N21/39 , G01N33/497 , G01N1/40 , G01J3/42 , G01N21/3504 , G01N21/552 , G01J3/02 , G01N21/31 , G01J3/10 , G06N20/00 , G01N21/77
摘要： Methods and systems for analyzing a sample and generating a predictive model using cavity ring-down spectroscopy are disclosed. At least part of a sample is loaded in a ring-down cavity. For each of a set of wavelengths, a laser beam is generated and directed into the ring-down cavity. The laser beam entering the ring-down cavity is extinguished. Light intensity decay data for light exiting the ring-down cavity is registered via a light intensity sensor system. A probability is determined from the light intensity decay data for the set of wavelengths that a subject from which the sample was received has a physiological condition or a degree of the physiological condition at least indirectly using a dataset of light intensity decay data for previously analyzed samples for which the presence or the absence of the physiological condition or the degree of the physiological condition have been identified.
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5.发明申请公开(公告)号：US20200319100A1
公开(公告)日：2020-10-08
申请号：US16740026
申请日：2020-01-10
申请人： Picomole Inc.
发明人： Gisia BEYDAGHYAN , Christopher Quentin PURVES , Stephen Douglas GRAHAM , Erik Justin SCHEME , Angkoon PHINYOMARK
IPC分类号： G01N21/39 , G01N33/497 , G01N1/40
摘要： Methods and systems for analyzing a sample and generating a predictive model using cavity ring-down spectroscopy are disclosed. At least part of a sample is loaded in a ring-down cavity. For each of a set of wavelengths, a laser beam is generated and directed into the ring-down cavity. The laser beam entering the ring-down cavity is extinguished. Light intensity decay data for light exiting the ring-down cavity is registered via a light intensity sensor system. A probability is determined from the light intensity decay data for the set of wavelengths that a subject from which the sample was received has a physiological condition or a degree of the physiological condition at least indirectly using a dataset of light intensity decay data for previously analyzed samples for which the presence or the absence of the physiological condition or the degree of the physiological condition have been identified.
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公开(公告)号：US11946857B2
公开(公告)日：2024-04-02
申请号：US16984740
申请日：2020-08-04
申请人： Picomole Inc.
CPC分类号： G01N21/0303 , G01N21/031 , G01N21/39 , G01N21/61 , H01S3/10 , H01S5/141 , H10N30/20 , H10N30/802
摘要： A method and system for frequency matching a resonant cavity is disclosed. Light is received in a resonant cavity having at least a first mirror and a second mirror defining a path along which light is reflected. At least the second mirror is actuatable to vary the length of the path of the resonant cavity. An intensity of the light exiting or reflecting from the resonant cavity is monitored, and an error correction is determined. The second mirror is actuated towards a pose relative to the first mirror at which a frequency of the light is in resonance with the length of the path. In this manner, the resonant cavity is frequency matched to the light to maintain the resonant cavity in resonance.
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公开(公告)号：US11506601B2
公开(公告)日：2022-11-22
申请号：US17160791
申请日：2021-01-28
申请人： Picomole Inc.
IPC分类号： G01J3/45 , G01N21/39 , G01N33/497 , G01N1/40 , G01J3/42 , G01N21/3504 , G01N21/552 , G01J3/02 , G01N21/31 , G01J3/10 , G06N20/00 , G01N21/77
摘要： There is provided a resonant cavity system. A first mirror is actuated at a first end of a resonant cavity to move in a direction between a first position relative to a second mirror at a second end of the resonant cavity, at which a cavity length between the first mirror and the second mirror is less than a resonance length for a laser beam, and a second position relative to the second mirror, at which the cavity length is greater than the resonance length. An event is triggered when the cavity length is proximal to the resonance length. The first mirror is continuously actuated to move in the direction between the first position and the second position during the event.
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公开(公告)号：US20210267484A1
公开(公告)日：2021-09-02
申请号：US17034311
申请日：2020-09-28
申请人： Picomole Inc.
IPC分类号： A61B5/097
摘要： Apparatuses and methods for collecting a breath sample are provided. A breath input interface is configured to receive exhaled breath. A conduit system extends from the breath input interface and is configured to receive a breath sample storage device at a first end thereof. A storage device valve is positioned on the conduit system towards the first end thereof. At least one controller is configured to open the storage device valve before the breath sample storage device is connected to the first end of the conduit system to allow breath received via the breath input interface to fill the conduit system between the breath input interface and the storage device valve, and subsequently close the storage device valve prior to connection of the breath sample storage device to the conduit system.
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公开(公告)号：US20210267482A1
公开(公告)日：2021-09-02
申请号：US16805161
申请日：2020-02-28
申请人： Picomole Inc.
摘要： An apparatus and method for collecting a breath sample are provided. The apparatus includes a breath input interface configured to receive exhaled breath, a metering device configured to determine a constituent level in the breath being received, a first conduit system extending from the breath input interface and connected to at least one breath sample storage device, a valve positioned along the first conduit system to control a flow of the exhaled breath towards the at least one breath sample storage device, and at least one controller configured to determine if the constituent level is within a constituent level target range, if a change rate in the constituent level is within a constituent level change rate target range, and control the valve to open at least partially based on these conditions.
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公开(公告)号：US11035789B2
公开(公告)日：2021-06-15
申请号：US16509207
申请日：2019-07-11
申请人： Picomole Inc.
IPC分类号： G01N21/31 , G01N21/39 , G01N33/497 , G01N1/40 , G01J3/42 , G01N21/3504 , G01N21/552 , G01J3/02 , G01J3/10 , G06N20/00 , G01N21/77
摘要： A cavity ring-down spectroscopy system and a method of modulating a light beam therein are provided. The cavity ring-down spectroscopy system includes at least one laser that generates a light beam, a first optical modulator positioned to attenuate the light beam from the at least one laser, a second optical modulator positioned to attenuate the light beam from the first optical modulator, a ring-down cavity positioned to receive the light beam from the second optical modulator, and at least one light sensor to detect an intensity of light leaked from the ring-down cavity.
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